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17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior.

التفاصيل البيبلوغرافية
العنوان: 17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior.
المؤلفون: Steyn FJ; University of Queensland Centre for Clinical Research, Faculty of Medicine, Brisbane, Qld, Australia.; Department of Neurology, Royal Brisbane & Women's Hospital, Brisbane, Qld, Australia.; Wesley Medical Research, Auchenflower, Qld, Australia., Ngo ST; University of Queensland Centre for Clinical Research, Faculty of Medicine, Brisbane, Qld, Australia.; Department of Neurology, Royal Brisbane & Women's Hospital, Brisbane, Qld, Australia.; Wesley Medical Research, Auchenflower, Qld, Australia.; Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, Qld, Australia.; Queensland Brain Institute, University of Queensland, Brisbane, Qld, Australia., Chen VP; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Bailey-Downs LC; Department of Nutritional Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Xie TY; School of Biomedical Sciences, The University of Queensland, Brisbane, Qld, Australia., Ghadami M; School of Biomedical Sciences, The University of Queensland, Brisbane, Qld, Australia., Brimijoin S; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Freeman WM; Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.; Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.; Harold Hamm Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Rubinstein M; Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina.; Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina.; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA., Low MJ; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA., Stout MB; Department of Nutritional Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.; Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.; Harold Hamm Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
المصدر: Aging cell [Aging Cell] 2018 Feb; Vol. 17 (1). Date of Electronic Publication: 2017 Nov 23.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-9726 (Electronic) Linking ISSN: 14749718 NLM ISO Abbreviation: Aging Cell
أسماء مطبوعة: Publication: Oxford, UK : Wiley-Blackwell
Original Publication: Oxford, UK : Blackwell Pub., c2002-
مواضيع طبية MeSH: Estradiol/*pharmacology , Feeding Behavior/*drug effects , Hypothalamus/*drug effects , Neurons/*drug effects , Pro-Opiomelanocortin/*pharmacology, Animals ; Arcuate Nucleus of Hypothalamus/drug effects ; Arcuate Nucleus of Hypothalamus/metabolism ; Behavior, Animal/drug effects ; Eating/drug effects ; Hypothalamus/metabolism ; Leptin/metabolism ; Mice, Transgenic ; Neurons/metabolism ; Obesity/metabolism ; Pro-Opiomelanocortin/metabolism
مستخلص: Weight loss is an effective intervention for diminishing disease burden in obese older adults. Pharmacological interventions that reduce food intake and thereby promote weight loss may offer effective strategies to reduce age-related disease. We previously reported that 17α-estradiol (17α-E2) administration elicits beneficial effects on metabolism and inflammation in old male mice. These observations were associated with reduced calorie intake. Here, we demonstrate that 17α-E2 acts through pro-opiomelanocortin (Pomc) expression in the arcuate nucleus (ARC) to reduce food intake and body mass in mouse models of obesity. These results confirm that 17α-E2 modulates appetite through selective interactions within hypothalamic anorexigenic pathways. Interestingly, some peripheral markers of metabolic homeostasis were also improved in animals with near complete loss of ARC Pomc transcription. This suggests that 17α-E2 might have central and peripheral actions that can beneficially affect metabolism cooperatively or independently.
(© 2017 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.)
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معلومات مُعتمدة: R01 DK066604 United States DK NIDDK NIH HHS; R01 DK068400 United States DK NIDDK NIH HHS; P30 DK020572 United States DK NIDDK NIH HHS; U2C DK110768 United States DK NIDDK NIH HHS; K99 AG051661 United States AG NIA NIH HHS
فهرسة مساهمة: Keywords: 17α-estradiol; aging; food intake; hypothalamus; obesity; pro-opiomelanocortin
المشرفين على المادة: 0 (Leptin)
4TI98Z838E (Estradiol)
66796-54-1 (Pro-Opiomelanocortin)
تواريخ الأحداث: Date Created: 20171124 Date Completed: 20190730 Latest Revision: 20211206
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC5770854
DOI: 10.1111/acel.12703
PMID: 29168299
قاعدة البيانات: MEDLINE
الوصف
تدمد:1474-9726
DOI:10.1111/acel.12703