دورية أكاديمية
Chrysophyllum cainito (apple-star): a fruit with gastroprotective activity in experimental ulcer models.
| العنوان: | Chrysophyllum cainito (apple-star): a fruit with gastroprotective activity in experimental ulcer models. |
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| المؤلفون: | da Rosa RL; Programa de Pós-Graduação em Ciências Farmacêuticas, Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí (UNIVALI)-Campus Itajai, Santa Catarina, Rua Uruguai, 458, Itajaí, SC, 88302-901, Brazil., de Almeida CL; Programa de Pós-Graduação em Ciências Farmacêuticas, Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí (UNIVALI)-Campus Itajai, Santa Catarina, Rua Uruguai, 458, Itajaí, SC, 88302-901, Brazil., Somensi LB; Programa de Pós-Graduação em Ciências Farmacêuticas, Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí (UNIVALI)-Campus Itajai, Santa Catarina, Rua Uruguai, 458, Itajaí, SC, 88302-901, Brazil., Boeing T; Programa de Pós-Graduação em Ciências Farmacêuticas, Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí (UNIVALI)-Campus Itajai, Santa Catarina, Rua Uruguai, 458, Itajaí, SC, 88302-901, Brazil., Mariano LNB; Programa de Pós-Graduação em Ciências Farmacêuticas, Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí (UNIVALI)-Campus Itajai, Santa Catarina, Rua Uruguai, 458, Itajaí, SC, 88302-901, Brazil., de Medeiros Amorim Krueger C; Programa de Pós-Graduação em Ciências Farmacêuticas, Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí (UNIVALI)-Campus Itajai, Santa Catarina, Rua Uruguai, 458, Itajaí, SC, 88302-901, Brazil., de Souza P; Programa de Pós-Graduação em Ciências Farmacêuticas, Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí (UNIVALI)-Campus Itajai, Santa Catarina, Rua Uruguai, 458, Itajaí, SC, 88302-901, Brazil., Filho VC; Programa de Pós-Graduação em Ciências Farmacêuticas, Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí (UNIVALI)-Campus Itajai, Santa Catarina, Rua Uruguai, 458, Itajaí, SC, 88302-901, Brazil., da Silva LM; Programa de Pós-Graduação em Ciências Farmacêuticas, Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí (UNIVALI)-Campus Itajai, Santa Catarina, Rua Uruguai, 458, Itajaí, SC, 88302-901, Brazil., de Andrade SF; Programa de Pós-Graduação em Ciências Farmacêuticas, Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí (UNIVALI)-Campus Itajai, Santa Catarina, Rua Uruguai, 458, Itajaí, SC, 88302-901, Brazil. faloni@univali.br. |
| المصدر: | Inflammopharmacology [Inflammopharmacology] 2019 Oct; Vol. 27 (5), pp. 985-996. Date of Electronic Publication: 2017 Dec 08. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Birkhäuser Country of Publication: Switzerland NLM ID: 9112626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1568-5608 (Electronic) Linking ISSN: 09254692 NLM ISO Abbreviation: Inflammopharmacology Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Basel ; Boston : Birkhäuser Original Publication: Dordrecht, The Netherlands ; Norwell, MA, USA : Kluwer Academic Publishers, c1991- |
| مواضيع طبية MeSH: | Anti-Ulcer Agents/*pharmacology , Fruit/*chemistry , Gastric Mucosa/*drug effects , Sapotaceae/*chemistry , Stomach Ulcer/*drug therapy, Animals ; Disease Models, Animal ; Ethanol/chemistry ; Female ; Indomethacin/pharmacology ; Mice ; NG-Nitroarginine Methyl Ester/pharmacology ; Phytotherapy/methods ; Plant Extracts/pharmacology ; Plant Leaves/chemistry |
| مستخلص: | The gastroprotective potential of the methanolic extracts from peels (MEPe), seeds (MESe) and pulp (MEPu) of Chrysophyllum cainito L. (Sapotaceae) fruits was evaluated in mice using ethanol/HCl- and indomethacin-induced ulcer, as well as the antiulcer effect of the juice and flour from this fruit. The lowest oral gastroprotective dose of MEPe, MESe and MEPu against ethanol/HCl was 3, 3 and 10 mg/kg, respectively. Moreover, all extracts increased mucin secretion at 176, 198 and 193%. Intraperitoneal administration of MEPe (0.3 mg/kg), MESe (0.3 mg/kg) and MEPu (1 mg/kg) also promoted gastroprotection against ethanol/HCl. In addition, MEPe (3 mg/kg, p.o), MESe (3 mg/kg, p.o) and MEPu (10 mg/kg, p.o) reduced indomethacin-induced gastric ulcer in mice by 78, 70 and 50%, respectively. Regarding the mode of action, the gastroprotective effect of MEPe was decreased by the pre-administration of N-ethylmaleimide (NEM, a sulfhydryl group chelator, 10 mg/kg, i.p), glibenclamide (a potassium channel blocker, 10 mg/kg, i.p), yohimbine (10 mg/kg, i.p, an alpha-adrenergic receptor antagonist, 10 mg/kg, i.p) and indomethacin (a cyclooxygenase inhibitor, 10 mg/kg, i.p). The gastroprotective effect of MESe was reduced by the pre-administration of NEM, glibenclamide, N-Nitro-L-arginine methyl ester (L-NAME, a nitric oxide synthase inhibitor, 70 mg/kg, i.p) and yohimbine, while MEPu had the gastroprotective effect decreased in animals pretreated with NEM and L-NAME. However, the extracts did not reduce gastric acid secretion. The supplementation with the flour from C. cainito fruit at 10% by 7 days, but not the juice intake, displayed gastroprotective potential, evidencing the fruit as a promising functional food. Together, the antiulcer effect of extracts of the C. cainito fruit in different experimental models was confirmed by the favoring of mucosal protective mechanisms among different, but complementary, modes of action. In parallel, the gastroprotective effects of the flour from C. cainito fruit were also described. |
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| فهرسة مساهمة: | Keywords: Chrysophyllum cainito; Functional food; Gastric ulcer; Gastroprotection |
| المشرفين على المادة: | 0 (Anti-Ulcer Agents) 0 (Plant Extracts) 3K9958V90M (Ethanol) V55S2QJN2X (NG-Nitroarginine Methyl Ester) XXE1CET956 (Indomethacin) |
| تواريخ الأحداث: | Date Created: 20171210 Date Completed: 20191127 Latest Revision: 20220720 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1007/s10787-017-0427-z |
| PMID: | 29222687 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1568-5608 |
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| DOI: | 10.1007/s10787-017-0427-z |