دورية أكاديمية
Novel bovine-associated pVAPN plasmid type in Rhodococcus equi identified from lymph nodes of slaughtered cattle and lungs of people living with HIV/AIDS.
| العنوان: | Novel bovine-associated pVAPN plasmid type in Rhodococcus equi identified from lymph nodes of slaughtered cattle and lungs of people living with HIV/AIDS. |
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| المؤلفون: | Ribeiro MG; Department of Veterinary Hygiene and Public Health, School of Veterinary Medicine and Animal Sciences, UNESP-São Paulo State University, Botucatu, SP, Brazil., Lara GHB; Department of Veterinary Hygiene and Public Health, School of Veterinary Medicine and Animal Sciences, UNESP-São Paulo State University, Botucatu, SP, Brazil., da Silva P; IAL-Adolfo Lutz Institute, Ribeirão Preto, SP, Brazil., Franco MMJ; Department of Veterinary Hygiene and Public Health, School of Veterinary Medicine and Animal Sciences, UNESP-São Paulo State University, Botucatu, SP, Brazil., de Mattos-Guaraldi AL; UERJ-Rio de Janeiro State University, Rio de Janeiro, RJ, Brazil., de Vargas APC; UFSM-Federal University of Santa Maria, Santa Maria, RS, Brazil., Sakate RI; Federal Veterinary Inspection Service, Lençois Paulista, SP, Brazil., Pavan FR; UNESP-Faculty of Pharmacy, Araraquara, SP, Brazil., Colhado BS; Department of Veterinary Hygiene and Public Health, School of Veterinary Medicine and Animal Sciences, UNESP-São Paulo State University, Botucatu, SP, Brazil., Portilho FVR; Department of Veterinary Hygiene and Public Health, School of Veterinary Medicine and Animal Sciences, UNESP-São Paulo State University, Botucatu, SP, Brazil., Motta RG; UniRV-University of Rio Verde, Rio Verde, GO, Brazil., Kakuda T; Kitasato University, Towada, Aomori, Japan., Takai S; Kitasato University, Towada, Aomori, Japan. |
| المصدر: | Transboundary and emerging diseases [Transbound Emerg Dis] 2018 Apr; Vol. 65 (2), pp. 321-326. Date of Electronic Publication: 2017 Dec 10. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Blackwell Verlag Country of Publication: Germany NLM ID: 101319538 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1865-1682 (Electronic) Linking ISSN: 18651674 NLM ISO Abbreviation: Transbound Emerg Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin : Blackwell Verlag |
| مواضيع طبية MeSH: | Actinomycetales Infections/*veterinary , Bacterial Proteins/*genetics , Cattle Diseases/*microbiology , HIV Infections/*microbiology , Lung Diseases/*microbiology , Lymph Nodes/*microbiology , Rhodococcus equi/*isolation & purification , Virulence Factors/*genetics, Actinomycetales Infections/microbiology ; Animals ; Cattle ; DNA, Bacterial/genetics ; Feces ; Humans ; Plasmids/genetics ; Prevalence ; Rhodococcus equi/genetics |
| مستخلص: | Rhodococcus equi is a well-recognized Gram-positive intracellular facultative bacterium that is opportunistic in nature, which causes pyogranulomatous infections in humans and multiple host animals. The pathogenicity of the microorganism has been attributed to the presence of plasmid-encoded virulence-associated proteins (Vap). To date, three host-associated virulence plasmid types of R. equi have been identified as follows: the circular pVAPA and pVAPB, related, respectively, to equine and porcine isolates, and a recently described linear pVAPN plasmid associated with bovine strains, although these three types are found in human isolates. Recent phylogenomic studies support the evidence that human R. equi infection is zoonotically acquired. Nevertheless, data regarding distribution and prevalence of the host-adapted virulence plasmid types of R. equi isolated from meat animals are scarce or unnoticed. Here, the three host-associated virulence plasmid types (pVAPA, pVAPB, and pVAPN) were investigated in 154 R. equi isolates recovered from lymph nodes of cattle with lymphadenitis (n = 31), faeces of cattle without enteric signs (n = 49), as well as different clinical specimens from human patients (n = 74). The analysis of virulence profile of 74 R. equi from humans revealed six (8.1%) isolates pVAPB (type 8), two (2.7%) pVAPN, and one (1.3%) pVAPB (type 11), all of which were from lung samples from people living with HIV/AIDS. From the lymph node samples of cattle, 41.9% (13 of 31) isolates revealed pVAPN type, whereas all isolates from faecal samples were negative for three host-associated types. Here, recently described bovine-associated pVAPN type was detected in R. equi isolates recovered from the lungs of people living with HIV/AIDS and lymph nodes from slaughtered cattle intended for human consumption; a finding that represents a public health concern, mainly in countries where undercooked or raw meat are traditionally consumed. (© 2017 Blackwell Verlag GmbH.) |
| فهرسة مساهمة: | Keywords: bovine rhodococcosis; emerging disease; host-associated plasmid types; immunocompromised human patients; pVAPN |
| المشرفين على المادة: | 0 (Bacterial Proteins) 0 (DNA, Bacterial) 0 (Virulence Factors) |
| تواريخ الأحداث: | Date Created: 20171212 Date Completed: 20180720 Latest Revision: 20181202 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1111/tbed.12785 |
| PMID: | 29226632 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1865-1682 |
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| DOI: | 10.1111/tbed.12785 |