دورية أكاديمية
Alterations in Acrolein Metabolism Contribute to Alzheimer's Disease.
| العنوان: | Alterations in Acrolein Metabolism Contribute to Alzheimer's Disease. |
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| المؤلفون: | Tsou HH; Institute of Environmental and Occupational Health Sciences, National Yang-Ming University, Taipei, Taiwan., Hsu WC; Department of Pharmacology, National Yang-Ming University, Taipei, Taiwan., Fuh JL; Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan.; Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.; Brain Research Center, National Yang-Ming University, Taipei, Taiwan., Chen SP; Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan.; Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.; Brain Research Center, National Yang-Ming University, Taipei, Taiwan.; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan., Liu TY; Institute of Environmental and Occupational Health Sciences, National Yang-Ming University, Taipei, Taiwan.; Institute of Food Safety and Health Risk Assessment, National Yang-Ming University, Taipei, Taiwan., Wang HT; Department of Pharmacology, National Yang-Ming University, Taipei, Taiwan. |
| المصدر: | Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2018; Vol. 61 (2), pp. 571-580. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: IOS Press Country of Publication: Netherlands NLM ID: 9814863 Publication Model: Print Cited Medium: Internet ISSN: 1875-8908 (Electronic) Linking ISSN: 13872877 NLM ISO Abbreviation: J Alzheimers Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam ; Washington : IOS Press, c1998- |
| مواضيع طبية MeSH: | Acetylcysteine/*analogs & derivatives , Acrolein/*metabolism , Alzheimer Disease/*metabolism , Creatinine/*urine, Acetylcysteine/urine ; Acrolein/analysis ; Aged ; Aged, 80 and over ; Alzheimer Disease/diagnosis ; Biomarkers/analysis ; Case-Control Studies ; Disease Progression ; Early Diagnosis ; Female ; Humans ; Male ; Middle Aged |
| مستخلص: | Alzheimer's disease (AD) is a detrimental neurodegenerative disease, and early diagnosis appears to be the key to successful treatment. Acrolein, a byproduct of lipid peroxidation, has been shown to contribute to the pathological process of AD. This study recruited 118 elderly subjects consisting of 58 non-demented control subjects and 62 AD patients. We analyzed the acrolein-related metabolites in the plasma, cerebrospinal fluid (CSF), and urine of all subjects. We found that the levels of acrolein-conjugated protein (Acr-PC) in the plasma (p = 0.00012) and CSF (p = 0.00161) of AD patients were significantly higher than those of control subjects, whereas the levels of a urinary acrolein metabolite, 3-hydroxypropyl mercapturic acid (3-HPMA), were markedly decreased (p = 0.00882) in AD patients. These data suggest that deregulated acrolein metabolism may be correlated with neuronal damage in AD patients, which might provide further insights into the disease progression and early diagnosis of AD. |
| فهرسة مساهمة: | Keywords: 3-HPMA; Acrolein; Alzheimer’s disease; acrolein-conjugated protein (Acr-PC) |
| المشرفين على المادة: | 0 (Biomarkers) 7864XYD3JJ (Acrolein) AYI8EX34EU (Creatinine) BFU3149V95 (S-(3-hydroxypropyl)cysteine N-acetate) WYQ7N0BPYC (Acetylcysteine) |
| تواريخ الأحداث: | Date Created: 20171212 Date Completed: 20190115 Latest Revision: 20220408 |
| رمز التحديث: | 20231215 |
| DOI: | 10.3233/JAD-170736 |
| PMID: | 29226874 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1875-8908 |
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| DOI: | 10.3233/JAD-170736 |