دورية أكاديمية
Antimicrobial Furoquinoline Alkaloids from Vepris lecomteana (Pierre) Cheek & T. Heller (Rutaceae).
| العنوان: | Antimicrobial Furoquinoline Alkaloids from Vepris lecomteana (Pierre) Cheek & T. Heller (Rutaceae). |
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| المؤلفون: | Kouam ADK; Department of Chemistry, University of Douala, Faculty of Sciences, 24157 Douala, Cameroon. arydolls@gmail.com.; Organic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, 33501 Bielefeld, Germany. arydolls@gmail.com., Bissoue AN; Department of Chemistry, University of Douala, Faculty of Sciences, 24157 Douala, Cameroon. anbissoue@yahoo.fr., Tcho AT; Department of Chemistry, University of Buea, Faculty of Sciences, 63 Buea, Cameroon. alainstone1@yahoo.fr., Happi EN; Department of Chemistry, University of Douala, Faculty of Sciences, 24157 Douala, Cameroon. ngeufa@yahoo.fr., Waffo AFK; Department of Chemistry, University of Douala, Faculty of Sciences, 24157 Douala, Cameroon. akamdemfr@yahoo.fr., Sewald N; Organic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, 33501 Bielefeld, Germany. norbert.sewald@uni-bielefeld.de., Wansi JD; Department of Chemistry, University of Douala, Faculty of Sciences, 24157 Douala, Cameroon. jdwansi@yahoo.fr. |
| المصدر: | Molecules (Basel, Switzerland) [Molecules] 2017 Dec 21; Vol. 23 (1). Date of Electronic Publication: 2017 Dec 21. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, c1995- |
| مواضيع طبية MeSH: | Alkaloids/*isolation & purification , Anti-Bacterial Agents/*isolation & purification , Quinolines/*isolation & purification , Rutaceae/*chemistry, Alkaloids/chemistry ; Anti-Bacterial Agents/chemistry ; Bacillus subtilis/drug effects ; Escherichia coli/drug effects ; Humans ; Microbial Sensitivity Tests/methods ; Micrococcus luteus/drug effects ; Molecular Structure ; Plant Extracts/chemistry ; Plant Leaves/chemistry ; Plant Stems/chemistry ; Quinolines/chemistry ; Staphylococcaceae/drug effects |
| مستخلص: | Three new prenylated furoquinoline alkaloids named lecomtequinoline A ( 1 ), B ( 2 ), and C ( 3 ), together with the known compounds anhydroevoxine ( 4 ), evoxine ( 5 ), dictamnine ( 6 ), N- methylflindersine ( 7 ), evoxanthine ( 8 ), hesperidin, lupeol, β -sitosterol, stigmasterol, β -sitosterol-3- O - β -d-glucopyranoside, stearic acid, and myristyl alcohol, were isolated by bioassay-guided fractionation of the methanolic extracts of leaves and stem of Vepris lecomteana . The structures of compounds were determined by spectroscopic methods (NMR, MS, UV, and IR) and by comparison with previously reported data. Crude extracts of leaves and stem displayed high antimicrobial activity, with Minimum Inhibitory Concentration (MIC) (values of 10.1-16.5 and 10.2-20.5 µg/mL, respectively, against Escherichia coli , Bacillus subtilis , Pseudomonas agarici , Micrococcus luteus , and Staphylococcus warneri , while compounds 1 - 6 showed values ranging from 11.1 to 18.7 µg/mL or were inactive, suggesting synergistic effect. The extracts may find application in crude drug preparations in Western Africa where Vepris lecomteana is endemic, subject to negative toxicity results in vivo . Competing Interests: The authors declare no conflict of interest. |
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| فهرسة مساهمة: | Keywords: Vepris lecomteana; furoquinoline alkaloids; lecomte quinoline A–C |
| المشرفين على المادة: | 0 (Alkaloids) 0 (Anti-Bacterial Agents) 0 (Plant Extracts) 0 (Quinolines) |
| تواريخ الأحداث: | Date Created: 20171222 Date Completed: 20190110 Latest Revision: 20190110 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC5943922 |
| DOI: | 10.3390/molecules23010013 |
| PMID: | 29267257 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1420-3049 |
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| DOI: | 10.3390/molecules23010013 |