دورية أكاديمية
Evaluation of antibacterial and modifying action of catechin antibiotics in resistant strains.
| العنوان: | Evaluation of antibacterial and modifying action of catechin antibiotics in resistant strains. |
|---|---|
| المؤلفون: | Gomes FMS; Laboratory of Microbiology and Molecular Biology (LMBM), Department of Biological Chemistry/CCBS/URCA, Brazil. Electronic address: fernandalacen@gmail.com., da Cunha Xavier J; Laboratory of Semi-Arid Bioprospecting (Lab-Bioprospec), Department of Biological Chemistry/CCBS/URCA, Brazil. Electronic address: jayzecx@gmail.com., Dos Santos JFS; Laboratory of Semi-Arid Bioprospecting (Lab-Bioprospec), Department of Biological Chemistry/CCBS/URCA, Brazil. Electronic address: joycy.sampaio22@gmail.com., de Matos YMLS; Laboratory of Microbiology and Molecular Biology (LMBM), Department of Biological Chemistry/CCBS/URCA, Brazil. Electronic address: yedda.lobo@urca.br., Tintino SR; Laboratory of Microbiology and Molecular Biology (LMBM), Department of Biological Chemistry/CCBS/URCA, Brazil. Electronic address: saulorelison@gmail.com., de Freitas TS; Laboratory of Microbiology and Molecular Biology (LMBM), Department of Biological Chemistry/CCBS/URCA, Brazil. Electronic address: thiagocrato@hotmail.com., Coutinho HDM; Laboratory of Microbiology and Molecular Biology (LMBM), Department of Biological Chemistry/CCBS/URCA, Brazil. Electronic address: hdmcoutinho@gmail.com. |
| المصدر: | Microbial pathogenesis [Microb Pathog] 2018 Feb; Vol. 115, pp. 175-178. Date of Electronic Publication: 2017 Dec 21. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academic Press Country of Publication: England NLM ID: 8606191 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1208 (Electronic) Linking ISSN: 08824010 NLM ISO Abbreviation: Microb Pathog Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London ; Orlando : Academic Press, c1986- |
| مواضيع طبية MeSH: | Anti-Bacterial Agents/*pharmacology , Catechin/*pharmacology , Escherichia coli/*drug effects , Pseudomonas aeruginosa/*drug effects , Staphylococcus aureus/*drug effects, Drug Combinations ; Drug Synergism ; Humans ; Microbial Sensitivity Tests |
| مستخلص: | Diseases caused by bacteria are today one of the great problems of present time. Access to over-the-counter medication, the indiscriminate use of antibacterials and high rates of hospitalization have contributed to the increase in cases. This picture has led to the search for new alternative drugs. Thus, secondary metabolites have been reported as a possible treatment option, being evidenced in many researches to ascertain their combination with existing drugs. This research aimed to evaluate the antibacterial effect and the antibiotic activity modifying action of the catechin compound against Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus multiresistant strains. The determination of the Minimum Inhibitory Concentration (MIC) and the evaluation of the antimicrobial and potentiating effect were performed by broth microdilution. The MIC obtained forcatechin against all the used strains was indicated as not clinically relevant. The combination of catechin and antibacterial drugs, both Gram-negative and Gram-positive, was synergistic and antagonistic in some drugs. Therefore, phenolic compounds can assist in the fight against infections caused by bacteria. (Copyright © 2017 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Antibacterials; Polyphenols; Resistance; Secondary metabolites |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (Drug Combinations) 8R1V1STN48 (Catechin) |
| تواريخ الأحداث: | Date Created: 20171225 Date Completed: 20180828 Latest Revision: 20180828 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.micpath.2017.12.058 |
| PMID: | 29275130 |
| قاعدة البيانات: | MEDLINE |
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