دورية أكاديمية
The Role of Topical Thymoquinone in the Treatment of Acute Otitis Externa; an Experimental Study in Rats.
| العنوان: | The Role of Topical Thymoquinone in the Treatment of Acute Otitis Externa; an Experimental Study in Rats. |
|---|---|
| المؤلفون: | Demirel H; Department of Otorhinolaryngology, Mustafa Kemal University School of Medicine, Hatay, Turkey., Arlı C; Department of Otorhinolaryngology, Mustafa Kemal University School of Medicine, Hatay, Turkey., Özgür T; Department of Pathology, Mustafa Kemal University School of Medicine, Hatay, Turkey., İnci M; Department of Microbiology, Mustafa Kemal University School of Medicine, Hatay, Turkey., Dokuyucu R; Department of Physiology, Mustafa Kemal University School of Medicine, Hatay, Turkey. |
| المصدر: | The journal of international advanced otology [J Int Adv Otol] 2018 Aug; Vol. 14 (2), pp. 285-289. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: AVES Country of Publication: Turkey NLM ID: 101522982 Publication Model: Print Cited Medium: Print ISSN: 1308-7649 (Print) Linking ISSN: 13087649 NLM ISO Abbreviation: J Int Adv Otol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2016- > : İstanbul : AVES Original Publication: Ankara : Mediterranean Society of Otology and Audiology |
| مواضيع طبية MeSH: | Benzoquinones/*therapeutic use , Ear Canal/*drug effects , Otitis Externa/*drug therapy, Acute Disease ; Administration, Topical ; Animals ; Benzoquinones/administration & dosage ; Dexamethasone/administration & dosage ; Dexamethasone/therapeutic use ; Disease Models, Animal ; Ear Canal/pathology ; Glucocorticoids/therapeutic use ; Male ; Otitis Externa/pathology ; Rats ; Rats, Wistar ; Treatment Outcome |
| مستخلص: | Objective: The aim of this experimental study was to compare the dose-related effect of topical thymoquinone (TQ) with other topical agents used in the management of acute otitis externa (AOE) in a rat model. Materials and Methods: Forty-eight male Wistar albino rats were divided into six groups each with eight rats per group. Group I was the control group with no external otitis, whereas external otitis were created in the other five groups (study groups). Dexamethasone, 0.1% TQ, 0.4% TQ, ciprofloxacin, and 0.9% saline (NaCl) drops was applied once daily in Groups II-VI, respectively. The treatment was administered regularly for 10 days. Pathologic and microbiologic evaluation were performed. Pathologically, the thicknesses of the stroma and the epithelium in the external auditory canal (EAC) were measured using an occulometer. Edema in the stroma, density of inflammatory cells and blood vessels, presence of fibroblasts, and changes in collagen fibers in the EAC were evaluated in five different areas to obtain the area of highest concentration and classified into four grades (0=no change, 1=mild, 2=moderate, 3=severe). Results: The higher concentration of TQ (0.4%) was more effective than dexamethasone and 0.1% TQ with respect to antibacterial and the anti-inflammatory properties. Conclusion: TQ, particularly at a concentration of 0.4%, may be considered for topical application alone in the treatment of AOE, without any requirement for a combined treatment. |
| References: | Laryngoscope. 2002 Jul;112(7 Pt 1):1166-77. (PMID: 12169893) Acta Otolaryngol. 2005 Apr;125(4):346-52. (PMID: 15823803) Int Immunopharmacol. 2005 Dec;5(13-14):1749-70. (PMID: 16275613) Otolaryngol Head Neck Surg. 2006 Apr;134(4 Suppl):S4-23. (PMID: 16638473) Curr Med Res Opin. 2008 Dec;24(12):3531-42. (PMID: 19032135) Cochrane Database Syst Rev. 2010 Jan 20;(1):CD004740. (PMID: 20091565) Curr Eye Res. 2011 Jul;36(7):591-8. (PMID: 21604966) Ther Clin Risk Manag. 2011;7:325-36. (PMID: 21845055) Biochem Pharmacol. 2012 Feb 15;83(4):443-51. (PMID: 22005518) Am Fam Physician. 2012 Dec 1;86(11):1055-61. (PMID: 23198673) Asian Pac J Trop Biomed. 2013 May;3(5):337-52. (PMID: 23646296) Planta Med. 2016 Jan;82(1-2):8-16. (PMID: 26366755) Clin Exp Otorhinolaryngol. 2015 Dec;8(4):312-9. (PMID: 26622947) Eur Arch Otorhinolaryngol. 1997;254(3):115-9. (PMID: 9112030) |
| المشرفين على المادة: | 0 (Benzoquinones) 0 (Glucocorticoids) 7S5I7G3JQL (Dexamethasone) O60IE26NUF (thymoquinone) |
| تواريخ الأحداث: | Date Created: 20171229 Date Completed: 20191015 Latest Revision: 20200225 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC6354478 |
| DOI: | 10.5152/iao.2017.4213 |
| PMID: | 29283096 |
| قاعدة البيانات: | MEDLINE |
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