دورية أكاديمية
أعرض في EDS

Thromboelastometry and Platelet Function during Acclimatization to High Altitude.

التفاصيل البيبلوغرافية
العنوان: Thromboelastometry and Platelet Function during Acclimatization to High Altitude.
المؤلفون: Rocke AS; Apex (Altitude Physiology Expeditions), Edinburgh, United Kingdom., Paterson GG; Apex (Altitude Physiology Expeditions), Edinburgh, United Kingdom.; Edinburgh Medical School, University of Edinburgh, Edinburgh, United Kingdom., Barber MT; Apex (Altitude Physiology Expeditions), Edinburgh, United Kingdom., Jackson AIR; Apex (Altitude Physiology Expeditions), Edinburgh, United Kingdom.; Clinical and Experimental Sciences Academic Unit, University of Southampton, Southampton, United Kingdom., Main SE; Apex (Altitude Physiology Expeditions), Edinburgh, United Kingdom., Stannett C; Apex (Altitude Physiology Expeditions), Edinburgh, United Kingdom., Schnopp MF; Apex (Altitude Physiology Expeditions), Edinburgh, United Kingdom., MacInnis M, Baillie JK; Apex (Altitude Physiology Expeditions), Edinburgh, United Kingdom.; Division of Genetics and Genomics, The Roslin Institute, University of Edinburgh, Edinburgh, United Kingdom., Horn EH; Department of Clinical Haematology, St James's University Hospital, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom., Moores C; Department of Anaesthesia, Critical Care and Pain Medicine, Royal Infirmary of Edinburgh, NHS Lothian, Edinburgh, United Kingdom., Harrison P; Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom., Nimmo AF; Department of Anaesthesia, Critical Care and Pain Medicine, Royal Infirmary of Edinburgh, NHS Lothian, Edinburgh, United Kingdom., Thompson AAR; Apex (Altitude Physiology Expeditions), Edinburgh, United Kingdom.; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom.
المصدر: Thrombosis and haemostasis [Thromb Haemost] 2018 Jan; Vol. 118 (1), pp. 63-71. Date of Electronic Publication: 2018 Jan 05.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Thieme Country of Publication: Germany NLM ID: 7608063 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2567-689X (Electronic) Linking ISSN: 03406245 NLM ISO Abbreviation: Thromb Haemost Subsets: MEDLINE
أسماء مطبوعة: Publication: 2018- : Stuttgart : Thieme
Original Publication: Stuttgart, Schattauer.
مواضيع طبية MeSH: Acclimatization* , Altitude* , Platelet Function Tests* , Thrombelastography*, Thrombosis/*physiopathology, Adolescent ; Adult ; Blood Coagulation ; Bolivia ; Cohort Studies ; Female ; Healthy Volunteers ; Hemostasis ; Humans ; Hypoxia ; Male ; Oxygen/chemistry ; Proteome ; Risk ; Young Adult
مستخلص: Interaction between hypoxia and coagulation is important given the increased risk of thrombotic diseases in chronically hypoxic patients who reside at sea level and in residents at high altitude. Hypoxia alters the proteome of platelets favouring a prothrombotic phenotype, but studies of activation and consumption of specific coagulation factors in hypoxic humans have yielded conflicting results. We tested blood from 63 healthy lowland volunteers acclimatizing to high altitude (5,200 m) using thromboelastometry and assays of platelet function to examine the effects of hypoxia on haemostasis. Using data from two separate cohorts of patients following identical ascent profiles, we detected a significant delay in clot formation, but increased clot strength by day 7 at 5,200 m. The latter finding may be accounted for by the significant rise in platelet count and fibrinogen concentration that occurred during acclimatization. Platelet function assays revealed evidence of platelet hyper-reactivity, with shortened PFA-100 closure times and increased platelet aggregation in response to adenosine diphosphate. Post-expedition results were consistent with the normalization of coagulation following descent to sea level. These robust findings indicate that hypoxia increases platelet reactivity and, with the exception of the paradoxical delay in thromboelastometry clotting time, suggest a prothrombotic phenotype at altitude. Further work to elucidate the mechanism of platelet activation in hypoxia will be important and could impact upon the management of patients with acute or chronic hypoxic respiratory diseases who are at risk of thrombotic events.
Competing Interests: Conflicts of interest: A. Nimmo has received expenses for attending meetings and speaker's honoraria from TEM International. None of the other authors declares any conflicts of interest.
(Schattauer GmbH Stuttgart.)
التعليقات: Erratum in: Thromb Haemost. 2018 Apr;118(4):801. MacInnis, Martin [added]; Main, Shona [corrected to Main, Shona E]; Horne, Elizabeth H [corrected to Horn, Elizabeth H]. (PMID: 29618158)
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معلومات مُعتمدة: United Kingdom Wellcome Trust
المشرفين على المادة: 0 (Proteome)
S88TT14065 (Oxygen)
تواريخ الأحداث: Date Created: 20180106 Date Completed: 20190912 Latest Revision: 20190912
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC6260116
DOI: 10.1160/TH17-02-0138
PMID: 29304526
قاعدة البيانات: MEDLINE
الوصف
تدمد:2567-689X
DOI:10.1160/TH17-02-0138