دورية أكاديمية
Complex HLA association in paraneoplastic cerebellar ataxia with anti-Yo antibodies.
العنوان: | Complex HLA association in paraneoplastic cerebellar ataxia with anti-Yo antibodies. |
---|---|
المؤلفون: | Hillary RP; Center for Sleep Sciences and Medicine, Stanford University, 3165 Porter Drive, Palo Alto, CA 94304, USA., Ollila HM; Center for Sleep Sciences and Medicine, Stanford University, 3165 Porter Drive, Palo Alto, CA 94304, USA., Lin L; Center for Sleep Sciences and Medicine, Stanford University, 3165 Porter Drive, Palo Alto, CA 94304, USA., Desestret V; French Reference Center on Paraneoplastic Neurological Syndrome, Hospices Civils de Lyon, Hôpital Neurologique, F-69677 Bron, France; Institut NeuroMyoGene INSERM U1217/CNRS UMR 5310, Université de Lyon - Université Claude Bernard Lyon 1, F-69372 Lyon, France., Rogemond V; French Reference Center on Paraneoplastic Neurological Syndrome, Hospices Civils de Lyon, Hôpital Neurologique, F-69677 Bron, France; Institut NeuroMyoGene INSERM U1217/CNRS UMR 5310, Université de Lyon - Université Claude Bernard Lyon 1, F-69372 Lyon, France., Picard G; French Reference Center on Paraneoplastic Neurological Syndrome, Hospices Civils de Lyon, Hôpital Neurologique, F-69677 Bron, France; Institut NeuroMyoGene INSERM U1217/CNRS UMR 5310, Université de Lyon - Université Claude Bernard Lyon 1, F-69372 Lyon, France., Small M; French Reference Center on Paraneoplastic Neurological Syndrome, Hospices Civils de Lyon, Hôpital Neurologique, F-69677 Bron, France; Institut NeuroMyoGene INSERM U1217/CNRS UMR 5310, Université de Lyon - Université Claude Bernard Lyon 1, F-69372 Lyon, France., Arnulf I; French Reference Center on Paraneoplastic Neurological Syndrome, Hospices Civils de Lyon, Hôpital Neurologique, F-69677 Bron, France., Dauvilliers Y; Unité du Sommeil, CHRU Gui de Chauliac, National Reference Centre for Orphan Diseases, Narcolepsy, Idiopathic Hypersomnia, 80 avenue Augustin Fliche, 34295, Montpellier Cedex 5, INSERM U1061, Montpellier, France., Honnorat J; French Reference Center on Paraneoplastic Neurological Syndrome, Hospices Civils de Lyon, Hôpital Neurologique, F-69677 Bron, France; Institut NeuroMyoGene INSERM U1217/CNRS UMR 5310, Université de Lyon - Université Claude Bernard Lyon 1, F-69372 Lyon, France. Electronic address: jerome.honnorat@chu-lyon.fr., Mignot E; Center for Sleep Sciences and Medicine, Stanford University, 3165 Porter Drive, Palo Alto, CA 94304, USA. Electronic address: mignot@stanford.edu. |
المصدر: | Journal of neuroimmunology [J Neuroimmunol] 2018 Feb 15; Vol. 315, pp. 28-32. Date of Electronic Publication: 2017 Dec 18. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier/North-Holland Country of Publication: Netherlands NLM ID: 8109498 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8421 (Electronic) Linking ISSN: 01655728 NLM ISO Abbreviation: J Neuroimmunol Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: [Amsterdam] : Elsevier/North-Holland, c1981- |
مواضيع طبية MeSH: | Genetic Predisposition to Disease/*genetics , HLA Antigens/*genetics , Paraneoplastic Cerebellar Degeneration/*genetics, Breast Neoplasms/complications ; Breast Neoplasms/genetics ; Female ; Haplotypes ; Humans ; Ovarian Neoplasms/complications ; Ovarian Neoplasms/genetics |
مستخلص: | Anti-Yo paraneoplastic cerebellar degeneration (PCD) is a devastating autoimmune complication of gynecological cancers. We hypothesized that as for other autoimmune diseases, specific HLA haplotypes are associated. We conducted high resolution HLA typing of Class I/Class II in 40 cases versus ethnically matched controls. Three cases with anti-Yo antibodies and peripheral neuropathy were also included. We detected protective effects of DPA1*01:03~DPB1*04:01 (OR=0, p=0.0008), DRB1*04:01~DQA1*03:03(OR=0, p=0.0016) and DPA1*01:03~DPB1*04:01 (OR=0.35, p=0.0047) overall. Increased DRB1*13:01~DQA1*01:03~DQB1*06:03 was also found in PCD ovarian cases (OR=5.4, p=0.0016). These results suggest differential genetic susceptibility to anti-Yo per cancer and with a primary HLA Class II involvement. (Copyright © 2017 Elsevier B.V. All rights reserved.) |
فهرسة مساهمة: | Keywords: Anti-Yo; Ataxia; Breast cancer; Ovarian cancer; Paraneoplastic |
المشرفين على المادة: | 0 (HLA Antigens) |
تواريخ الأحداث: | Date Created: 20180108 Date Completed: 20190927 Latest Revision: 20190927 |
رمز التحديث: | 20221213 |
DOI: | 10.1016/j.jneuroim.2017.12.012 |
PMID: | 29306402 |
قاعدة البيانات: | MEDLINE |
كن أول من يترك تعليقا!