دورية أكاديمية
Early stages of HIV treatment cascade in people living with HIV in Saint-Petersburg, Russia.
| العنوان: | Early stages of HIV treatment cascade in people living with HIV in Saint-Petersburg, Russia. |
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| المؤلفون: | Vetrova MV; a Laboratory of Clinical Psychopharmacology of Addictions , Valdman Institute of Pharmacology, First Pavlov State Medical University of St. Petersburg , Saint-Petersburg , Russia.; b Department of Addictions , St. Petersburg Bekhterev Research Psychoneurological Institute , Saint-Petersburg , Russia., Aleksandrova OV; c Department of Psychology , St. Petersburg State University , Saint-Petersburg , Russia., Paschenko AE; d Laboratory of Theoretical and Interdisciplinary Informatics Problems , St. Petersburg Institute for Informatics and Automation of the Russian Academy of Sciences , Saint-Petersburg , Russia., Toropov SE; e St. Petersburg Centre for Control and Prevention of AIDS and Other Infection , Saint-Petersburg , Russia., Rassokhin VV; f Department of Infectious Diseases and Epidemiology , First Pavlov State Medical University of St. Petersburg , Saint-Petersburg , Russia.; g Laboratory of Immunology and Virology of HIV Infection , Saint-Petersburg Pasteur Institute , Saint-Petersburg , Russia., Abyshev RA; e St. Petersburg Centre for Control and Prevention of AIDS and Other Infection , Saint-Petersburg , Russia., Levina OS; h Regional NGO of Social Projects in the Sphere of Population's Wellbeing 'STELLIT' , St. Petersburg , Russia., Niccolai LM; i School of Public Health , Yale University , New Haven , USA., Heimer R; i School of Public Health , Yale University , New Haven , USA. |
| المصدر: | AIDS care [AIDS Care] 2018 Jul; Vol. 30 (7), pp. 857-862. Date of Electronic Publication: 2018 Jan 11. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 8915313 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1360-0451 (Electronic) Linking ISSN: 09540121 NLM ISO Abbreviation: AIDS Care Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: Abingdon, Oxfordshire, U.K. : Carfax Pub. Co., c1989- |
| مواضيع طبية MeSH: | Anti-HIV Agents/*therapeutic use , HIV Infections/*drug therapy, Adult ; Aged ; Disease Progression ; Female ; HIV Infections/epidemiology ; Humans ; Male ; Middle Aged ; Pilot Projects ; Russia/epidemiology ; Substance-Related Disorders/complications ; Treatment Outcome |
| مستخلص: | The proportion of people living with HIV (PLWH) in need of antiretroviral therapy (ART) is growing rapidly in Russia. Successful treatment outcomes reduces disease progression and contributes to HIV epidemic control. We conducted a pilot study following 100 PLWH newly found eligible for ART in St. Petersburg, Russia. We determined the proportion of PLWH who initiated ART, remained in treatment, and achieved an undetectable VL during 6-month follow up. Semi-structured interviews were conducted prior the initiation of ART and progress along the cascade was assessed through medical chart review. Individual characteristics associated with successful ART outcomes were assessed as part of efforts to generate hypotheses. Almost all (96%) participants initiated ART, full retention was demonstrated by 80%, among whom 71% achieved undetectable VL. Optimal retention was associated with older age and higher education (p < 0.05). There was no significant difference in ART outcomes between those who used illicit drugs and those had not. Interventions to improve treatment effectiveness should emphasize that initiation, optimal retention and achieving an undetectable VL are independent of drug abuse status. However, our pilot study highlights the need for the further research in the examining links between individual and structural factors and ART effectiveness. |
| معلومات مُعتمدة: | D43 TW001028 United States TW FIC NIH HHS |
| فهرسة مساهمة: | Keywords: ART; HIV; Russia; adherence; retention |
| المشرفين على المادة: | 0 (Anti-HIV Agents) |
| تواريخ الأحداث: | Date Created: 20180113 Date Completed: 20190930 Latest Revision: 20190930 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1080/09540121.2017.1417536 |
| PMID: | 29325435 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1360-0451 |
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| DOI: | 10.1080/09540121.2017.1417536 |