دورية أكاديمية
Effect of Anacardium occidentale leaf extract on human acute lymphoblastic leukaemia cell lines.
| العنوان: | Effect of Anacardium occidentale leaf extract on human acute lymphoblastic leukaemia cell lines. |
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| المؤلفون: | Santos JM; a Programa de Pós-Graduação em Biotecnologia Industrial, Universidade Tiradentes/Instituto de Tecnologia e Pesquisa , Aracaju , Brasil., Cury NM; b Laboratório de Biologia Molecular , Centro Infantil Boldrini , Campinas , Brasil., Yunes JA; b Laboratório de Biologia Molecular , Centro Infantil Boldrini , Campinas , Brasil.; c Faculdade de Ciências Médicas, Departamento de Genética Médica , UNICAMP , Campinas , Brasil., López JA; a Programa de Pós-Graduação em Biotecnologia Industrial, Universidade Tiradentes/Instituto de Tecnologia e Pesquisa , Aracaju , Brasil., Hernández-Macedo ML; a Programa de Pós-Graduação em Biotecnologia Industrial, Universidade Tiradentes/Instituto de Tecnologia e Pesquisa , Aracaju , Brasil. |
| المصدر: | Natural product research [Nat Prod Res] 2019 Jun; Vol. 33 (11), pp. 1633-1636. Date of Electronic Publication: 2018 Jan 16. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res |
| أسماء مطبوعة: | Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003- |
| مواضيع طبية MeSH: | Anacardium/*chemistry , Antineoplastic Agents, Phytogenic/*pharmacology , Plant Extracts/*pharmacology , Precursor Cell Lymphoblastic Leukemia-Lymphoma/*drug therapy, Apoptosis/drug effects ; Caspase 3/genetics ; Cell Cycle/drug effects ; Cell Line, Tumor ; Humans ; Phenols/analysis ; Plant Leaves/chemistry ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology |
| مستخلص: | Anacardium occidentale leaves are used in folk medicine due its therapeutic properties attributed to phenolic compounds. Therefore, this study was undertaken on its hydroethanolic leaf extract ( Ao HE) to evaluate cytotoxicity and apoptosis induction on acute lymphoblastic leukaemia cells. Results indicated that Ao HE interfered in the cell cycle progression, inducing apoptosis by activation of casp3 at lower concentrations, thence, a promising candidate for the development of new cancer drugs. |
| فهرسة مساهمة: | Keywords: Cashew; apoptosis; leukaemia cells; polyphenols |
| المشرفين على المادة: | 0 (Antineoplastic Agents, Phytogenic) 0 (Phenols) 0 (Plant Extracts) EC 3.4.22.- (CASP3 protein, human) EC 3.4.22.- (Caspase 3) |
| تواريخ الأحداث: | Date Created: 20180118 Date Completed: 20190805 Latest Revision: 20190805 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1080/14786419.2018.1425841 |
| PMID: | 29338345 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1478-6427 |
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| DOI: | 10.1080/14786419.2018.1425841 |