دورية أكاديمية
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Identification of Differentially Expressed Genes In Deltamethrin-Resistant Culex pipiens quinquefasciatus.

التفاصيل البيبلوغرافية
العنوان: Identification of Differentially Expressed Genes In Deltamethrin-Resistant Culex pipiens quinquefasciatus.
المؤلفون: Liu QM, Li CX, Wu Q, Shi QM, Sun AJ, Zhang HD, Guo XX, Dong YD, Xing D, Zhang YM, Han Q, Diao XP, Zhao TY
المصدر: Journal of the American Mosquito Control Association [J Am Mosq Control Assoc] 2017 Dec; Vol. 33 (4), pp. 324-330.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: American Mosquito Control Association Country of Publication: United States NLM ID: 8511299 Publication Model: Print Cited Medium: Internet ISSN: 1943-6270 (Electronic) Linking ISSN: 8756971X NLM ISO Abbreviation: J Am Mosq Control Assoc Subsets: MEDLINE
أسماء مطبوعة: Publication: : North Brunswick, NJ : American Mosquito Control Association
Original Publication: [Fresno, Calif.] : American Mosquito Control Association, [c1985-
مواضيع طبية MeSH: Culex/*genetics , Gene Expression/*drug effects , Insecticide Resistance/*genetics , Insecticides/*pharmacology , Nitriles/*pharmacology , Pyrethrins/*pharmacology, Animals ; China ; Culex/drug effects ; Culex/growth & development ; Larva/drug effects ; Larva/genetics ; Larva/growth & development
مستخلص: Culex quinquefasciatus is one of China's major house-dwelling mosquito species and an important vector of filariasis and encephalitis. Chemical treatments represent one of the most successful approaches for comprehensive mosquito prevention and control. However, the widespread use of chemical pesticides has led to the occurrence and development of insecticide resistance. Therefore, in-depth studies of resistance to insecticides are of vital importance. In this study, we performed a gene expression analysis to investigate genes from Cx. quinquefasciatus that may confer pyrethroid resistance. We aimed to understand the mechanisms of Cx. quinquefasciatus resistance to pyrethroid insecticides and provide insights into insect resistance management. Using a resistance bioassay, we determined the deltamethrin LC 50 values (lethal concentration required to kill 50% of the population) for Cx. quinquefasciatus larvae in the F 21 , F 23 , F 24 , F 26 , F 27 , and F 30 generations. The 7 tested strains exhibited pesticide resistance that was 25.25 to 87.83 times higher than that of the SanYa strain. Moreover, the expression of the OBPjj7a (odorant-binding protein OBPjj7a), OBP28 (odorant-binding protein OBP28), and E2 (ubiquitin-conjugating enzyme) genes was positively correlated with deltamethrin resistance ( R 2 = 0.836, P = 0.011; R 2 = 0.788, P = 0.018; and R 2 = 0.850, P = 0.009, respectively) in Cx. quinquefasciatus. The expression of 4 additional genes, H/ACA, S19, SAR2, and PGRP, was not correlated with deltamethrin resistance. In summary, this study identified 3 Cx. quinquefasciatus genes with potential involvement in deltamethrin resistance, and these results may provide a theoretical basis for the control of mosquito resistance and insights into resistance detection.
فهرسة مساهمة: Keywords: Culex quinquefasciatus; novel resistant gene; pyrethroid insecticide
المشرفين على المادة: 0 (Insecticides)
0 (Nitriles)
0 (Pyrethrins)
2JTS8R821G (decamethrin)
تواريخ الأحداث: Date Created: 20180126 Date Completed: 20190117 Latest Revision: 20190117
رمز التحديث: 20221213
DOI: 10.2987/17-6658.1
PMID: 29369035
قاعدة البيانات: MEDLINE
الوصف
تدمد:1943-6270
DOI:10.2987/17-6658.1