دورية أكاديمية
أعرض في EDS

An evolutionarily conserved gene family encodes proton-selective ion channels.

التفاصيل البيبلوغرافية
العنوان: An evolutionarily conserved gene family encodes proton-selective ion channels.
المؤلفون: Tu YH; Department of Biological Sciences, Section of Neurobiology, University of Southern California, Los Angeles, CA 90089, USA., Cooper AJ; Department of Biological Sciences, Section of Neurobiology, University of Southern California, Los Angeles, CA 90089, USA., Teng B; Department of Biological Sciences, Section of Neurobiology, University of Southern California, Los Angeles, CA 90089, USA., Chang RB; Department of Biological Sciences, Section of Neurobiology, University of Southern California, Los Angeles, CA 90089, USA., Artiga DJ; Department of Biological Sciences, Section of Neurobiology, University of Southern California, Los Angeles, CA 90089, USA., Turner HN; Department of Biological Sciences, Section of Neurobiology, University of Southern California, Los Angeles, CA 90089, USA., Mulhall EM; Department of Biological Sciences, Section of Neurobiology, University of Southern California, Los Angeles, CA 90089, USA., Ye W; Department of Biological Sciences, Section of Neurobiology, University of Southern California, Los Angeles, CA 90089, USA. liman@usc.edu., Smith AD; Department of Biological Sciences, Section of Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA., Liman ER; Department of Biological Sciences, Section of Neurobiology, University of Southern California, Los Angeles, CA 90089, USA. liman@usc.edu.; Bridge Institute, University of Southern California, Los Angeles, CA 90089, USA.
المصدر: Science (New York, N.Y.) [Science] 2018 Mar 02; Vol. 359 (6379), pp. 1047-1050. Date of Electronic Publication: 2018 Jan 25.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
أسماء مطبوعة: Publication: : Washington, DC : American Association for the Advancement of Science
Original Publication: New York, N.Y. : [s.n.] 1880-
مواضيع طبية MeSH: Ion Channels/*genetics , Ion Channels/*metabolism , Membrane Proteins/*genetics , Membrane Proteins/*metabolism , Taste Buds/*metabolism, Animals ; Conserved Sequence ; Drosophila melanogaster ; Evolution, Molecular ; HEK293 Cells ; Humans ; Ion Channels/classification ; Membrane Proteins/classification ; Mice ; Otolithic Membrane/growth & development ; Phylogeny ; Protons ; Tissue Distribution ; Transcriptome
مستخلص: Ion channels form the basis for cellular electrical signaling. Despite the scores of genetically identified ion channels selective for other monatomic ions, only one type of proton-selective ion channel has been found in eukaryotic cells. By comparative transcriptome analysis of mouse taste receptor cells, we identified Otopetrin1 (OTOP1), a protein required for development of gravity-sensing otoconia in the vestibular system, as forming a proton-selective ion channel. We found that murine OTOP1 is enriched in acid-detecting taste receptor cells and is required for their zinc-sensitive proton conductance. Two related murine genes, Otop2 and Otop3 , and a Drosophila ortholog also encode proton channels. Evolutionary conservation of the gene family and its widespread tissue distribution suggest a broad role for proton channels in physiology and pathophysiology.
(Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.)
التعليقات: Comment in: J Gen Physiol. 2018 Feb 26;:. (PMID: 29483132)
Comment in: Science. 2018 Mar 2;359(6379):991-992. (PMID: 29496867)
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معلومات مُعتمدة: R01 DC013741 United States DC NIDCD NIH HHS; R01 HG006015 United States HG NHGRI NIH HHS; R21 DC012747 United States DC NIDCD NIH HHS
المشرفين على المادة: 0 (Ion Channels)
0 (Membrane Proteins)
0 (Protons)
0 (otopetrin 1 protein, mouse)
تواريخ الأحداث: Date Created: 20180127 Date Completed: 20180502 Latest Revision: 20181113
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC5845439
DOI: 10.1126/science.aao3264
PMID: 29371428
قاعدة البيانات: MEDLINE
الوصف
تدمد:1095-9203
DOI:10.1126/science.aao3264