دورية أكاديمية
[Sex-specific associations between tobacco smoking and risk of cardiovascular diseases in Chinese adults].
| العنوان: | [Sex-specific associations between tobacco smoking and risk of cardiovascular diseases in Chinese adults]. |
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| المؤلفون: | Shen Q; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China., Zhu NB; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China., Yu CQ; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China., Guo Y; Chinese Academy of Medical Sciences, Beijing 100010, China., Bian Z; Chinese Academy of Medical Sciences, Beijing 100010, China., Tan YL; Chinese Academy of Medical Sciences, Beijing 100010, China., Pei P; Chinese Academy of Medical Sciences, Beijing 100010, China., Chen JS; China National Center for Food Safety Risk Assessment, Beijing 100020, China., Chen ZM; Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK., Lyu J; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China., Li LM; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China; Chinese Academy of Medical Sciences, Beijing 100010, China. |
| مؤلفون مشاركون: | China Kadoorie Biobank (CKB) Collaborative Group |
| المصدر: | Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi [Zhonghua Liu Xing Bing Xue Za Zhi] 2018 Jan 10; Vol. 39 (1), pp. 8-15. |
| نوع المنشور: | Journal Article |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Zhonghua yi xue hui; Zhongguo yi xue ke xue yuan Liu xing bing xue wei sheng wu xue yan jiu suo Country of Publication: China NLM ID: 8208604 Publication Model: Print Cited Medium: Print ISSN: 0254-6450 (Print) Linking ISSN: 02546450 NLM ISO Abbreviation: Zhonghua Liu Xing Bing Xue Za Zhi Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Beijing : Zhonghua yi xue hui; Zhongguo yi xue ke xue yuan Liu xing bing xue wei sheng wu xue yan jiu suo Original Publication: [Beijing] : Zhonghua yi xue hui; Zhongguo yi xue ke xue yuan Liu xing bing xue wei sheng wu xue yan jiu suo, [1981- |
| مواضيع طبية MeSH: | Asian People/*statistics & numerical data , Cardiovascular Diseases/*epidemiology , Smoking/*ethnology , Tobacco Smoking/*adverse effects, Adult ; China/epidemiology ; Female ; Humans ; Incidence ; Male ; Neoplasms/epidemiology ; Prevalence ; Prospective Studies ; Risk Factors ; Smoking/adverse effects ; Smoking Cessation ; Stroke/epidemiology |
| مستخلص: | Objective: To examine the sex-specific associations between tobacco smoking and risk of cardiovascular diseases in Chinese adults. Methods: The present analysis included 487 373 participants from the China Kadoorie Biobank after excluding those with cancer, heart diseases, stroke at baseline survey. The baseline survey was conducted from June 2004 to July 2008. The number of follow-up years was calculated from the time that the participants completed baseline survey to the time of any event: CVD incidence, death, loss of follow-up, or December 31, 2015, whichever occurred first. We used Cox proportional hazards regression models to estimate the HR s and 95% CI of incident cardiovascular diseases with tobacco smoking. Results: During a median follow-up of 8.9 years(a total of 4.1 million person years), we documented 33 947 cases of ischemic heart diseases, 6 048 cases of major coronary diseases, 7 794 cases of intracerebral hemorrhage, and 31 722 cases of cerebral infarction. The prevalence of smoking was much higher in men (67.9%) than in women (2.7%). Smoking increased risk of all subtypes of cardiovascular diseases. Compared with nonsmokers, the multivariable-adjusted HR s (95% CI ) for current smokers were 1.54 (1.43-1.66) for major coronary event, 1.28 (1.24-1.32) for ischemic heart disease, 1.18 (1.14-1.22) for cerebral infarction, and 1.07 (1.00-1.15) for intracerebral hemorrhage, respectively. Female smokers tended to have greater risk of developing major coronary event associated with amount of tobacco smoked daily (interaction P =0.006) and age when smoking started (interaction P =0.011). There was no sex difference in these two effects for ischemic heart diseases, intracerebral hemorrhage and cerebral infarction (all interaction P >0.05). Conclusions: This prospective study confirmed increased risk of all subtypes of cardiovascular diseases in current smokers. Smoking was more harmful to women than to men for major coronary event. |
| معلومات مُعتمدة: | 212946/Z/18/Z United Kingdom WT_ Wellcome Trust; MC_U137686851 United Kingdom MRC_ Medical Research Council; MC_UU_12026/2 United Kingdom MRC_ Medical Research Council |
| فهرسة مساهمة: | Keywords: Cardiovascular diseases; Sex specific difference; Tobacco smoking Local Abstract: [Publisher, Chinese] 目的： 分析中国成年人吸烟与不同心血管疾病发病风险的关联及其性别差异。 方法： 研究对象来自中国慢性病前瞻性研究，基线调查开展于2004年6月至2008年7月，剔除基线自报患有恶性肿瘤、冠心病、脑卒中的个体，最终纳入487 373名研究对象。随访人年数的计算从研究对象完成基线调查时开始，至最早出现以下任一事件的时间为止：心血管疾病（CVD）发病、死亡、失访或2015年12月31日。使用Cox比例风险模型计算吸烟行为特征和心血管疾病发病风险的关联。 结果： 研究对象平均随访8.9年。随访期间新发缺血性心脏病33 947人，急性冠心病事件6 048人，脑内出血7 794人，脑梗死31 722人。男性吸烟率（67.9%）远高于女性（2.7%）。与非吸烟者相比，吸烟能增加各类CVD结局的发病风险，风险效应值 HR 值（95% CI ）由大到小依次为急性冠心病事件1.54（1.43~1.66）、缺血性心脏病1.28（1.24~1.32）、脑梗死1.18（1.14~1.22）、脑内出血1.07（1.00~1.15）。当前吸烟者中，每天吸烟量和开始吸烟年龄与急性冠心病事件风险间的关联存在性别差异（性别交互作用 P 值分别为0.006、0.011），主要表现为女性吸烟者风险高于男性。每天吸烟量和开始吸烟年龄与缺血性心脏病、脑内出血和脑梗死之间的关联均未见性别差异（性别交互作用 P >0.05）。 结论： 吸烟能够增加各类CVD的发病风险，而女性吸烟者发生急性冠心病事件的风险远高于男性。. |
| تواريخ الأحداث: | Date Created: 20180129 Date Completed: 20180417 Latest Revision: 20221207 |
| رمز التحديث: | 20240829 |
| DOI: | 10.3760/cma.j.issn.0254-6450.2018.01.002 |
| PMID: | 29374887 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0254-6450 |
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| DOI: | 10.3760/cma.j.issn.0254-6450.2018.01.002 |