دورية أكاديمية
Antemortem-Postmortem Correlation of Florbetapir (18F) PET Amyloid Imaging with Quantitative Biochemical Measures of Aβ42 but not Aβ40.
| العنوان: | Antemortem-Postmortem Correlation of Florbetapir (18F) PET Amyloid Imaging with Quantitative Biochemical Measures of Aβ42 but not Aβ40. |
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| المؤلفون: | Beach TG; Banner Sun Health Research Institute, Sun City, AZ, USA., Maarouf CL; Banner Sun Health Research Institute, Sun City, AZ, USA., Intorcia A; Banner Sun Health Research Institute, Sun City, AZ, USA., Sue LI; Banner Sun Health Research Institute, Sun City, AZ, USA., Serrano GE; Banner Sun Health Research Institute, Sun City, AZ, USA., Lu M; Avid Radiopharmaceuticals, Philadelphia, PA, USA., Joshi A; Avid Radiopharmaceuticals, Philadelphia, PA, USA., Pontecorvo MJ; Avid Radiopharmaceuticals, Philadelphia, PA, USA., Roher AE; Banner Sun Health Research Institute, Sun City, AZ, USA.; Barrow Neurological Institute, Phoenix, AZ, USA. |
| المصدر: | Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2018; Vol. 61 (4), pp. 1509-1516. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: IOS Press Country of Publication: Netherlands NLM ID: 9814863 Publication Model: Print Cited Medium: Internet ISSN: 1875-8908 (Electronic) Linking ISSN: 13872877 NLM ISO Abbreviation: J Alzheimers Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam ; Washington : IOS Press, c1998- |
| مواضيع طبية MeSH: | Alzheimer Disease/*metabolism , Amyloid beta-Peptides/*metabolism , Brain/*diagnostic imaging , Brain/*pathology , Peptide Fragments/*metabolism, Aged ; Aged, 80 and over ; Amyloidosis/metabolism ; Aniline Compounds ; Autopsy ; Ethylene Glycols ; Humans ; Linear Models ; Plaque, Amyloid/metabolism ; Positron-Emission Tomography |
| مستخلص: | Amyloid imaging demonstrates the in vivo presence of amyloid-β (Aβ) deposits in the aging human brain but it is still unknown which structural forms and modifications of Aβ are detected. In Alzheimer's disease, most amyloid deposits are predominantly composed of Aβ ending at amino acid residues Val40 or Ala42. It has been reported that Aβ40 is largely restricted to neuritic plaques while Aβ42 may be deposited in amyloid plaques of all types, and is often the sole component of diffuse plaques. The distinction is important as it is mainly the neuritic plaques that correlate with cognitive impairment while diffuse plaques may be the initial type of Aβ deposited. Whether PET amyloid ligands such as florbetapir-18F (Amyvid) are partially or wholly selective for brain deposits of Aβ40 or Aβ42 is currently unknown. We compared antemortem florbetapir PET cortical/cerebellar signal intensity (SUVr) of 55 subjects with postmortem biochemical (ELISA) measurements employing specific antibodies against Aβ40 and Aβ42. Spearman's univariable correlations were significant for both Aβ40 and Aβ42, but were much stronger for Aβ42. Multiple linear regression showed significance only for Aβ42. These results suggest that florbetapir binds only weakly, if at all, to Aβ40. This may be in part due to the higher likelihood for Aβ42 to be present in a β-pleated sheet tertiary structure, or to differences between Aβ40 and Aβ42 in β-pleated sheet tertiary or quaternary structure. |
| فهرسة مساهمة: | Keywords: Alzheimer’s disease; autopsy; diagnosis; diffuse plaque; neuritic plaque |
| المشرفين على المادة: | 0 (Amyloid beta-Peptides) 0 (Aniline Compounds) 0 (Ethylene Glycols) 0 (Peptide Fragments) 0 (amyloid beta-protein (1-40)) 0 (amyloid beta-protein (1-42)) 6867Q6IKOD (florbetapir) |
| تواريخ الأحداث: | Date Created: 20180130 Date Completed: 20190124 Latest Revision: 20190124 |
| رمز التحديث: | 20221213 |
| DOI: | 10.3233/JAD-170762 |
| PMID: | 29376867 |
| قاعدة البيانات: | MEDLINE |
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