دورية أكاديمية
Motor unit number index and neurophysiological index as candidate biomarkers of presymptomatic motor neuron loss in amyotrophic lateral sclerosis.
| العنوان: | Motor unit number index and neurophysiological index as candidate biomarkers of presymptomatic motor neuron loss in amyotrophic lateral sclerosis. |
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| المؤلفون: | Escorcio-Bezerra ML; Department of Neurology and Neurosurgery, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Pedro de Toledo, 650, 04039-002, São Paulo, SP, Brazil., Abrahao A; Department of Neurology and Neurosurgery, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Pedro de Toledo, 650, 04039-002, São Paulo, SP, Brazil.; Sunnybrook Health Sciences Centre, Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada., Nunes KF; Department of Neurology and Neurosurgery, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Pedro de Toledo, 650, 04039-002, São Paulo, SP, Brazil., De Oliveira Braga NI; Department of Neurology and Neurosurgery, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Pedro de Toledo, 650, 04039-002, São Paulo, SP, Brazil., Oliveira ASB; Department of Neurology and Neurosurgery, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Pedro de Toledo, 650, 04039-002, São Paulo, SP, Brazil., Zinman L; Sunnybrook Health Sciences Centre, Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada., Manzano GM; Department of Neurology and Neurosurgery, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Pedro de Toledo, 650, 04039-002, São Paulo, SP, Brazil. |
| المصدر: | Muscle & nerve [Muscle Nerve] 2018 Aug; Vol. 58 (2), pp. 204-212. Date of Electronic Publication: 2018 Feb 12. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 7803146 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4598 (Electronic) Linking ISSN: 0148639X NLM ISO Abbreviation: Muscle Nerve Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2005-> : Hoboken, NJ : John Wiley & Sons Original Publication: New York, NY : John Wiley & Sons |
| مواضيع طبية MeSH: | Amyotrophic Lateral Sclerosis/*pathology , Motor Neurons/*pathology , Muscle Fibers, Skeletal/*pathology, Action Potentials ; Aged ; Biomarkers ; Cell Count ; Disease Progression ; Electrodiagnosis ; Female ; Hand Strength ; Humans ; Male ; Middle Aged ; Muscle Strength Dynamometer ; Prospective Studies ; Treatment Outcome |
| مستخلص: | Introduction: Our objective was to determine the utility of motor unit number index (MUNIX) and neurophysiological index (NI) as surrogate biomarkers of disease progression in limbs without clinical signs of lower motor neuron (LMN) involvement from patients with slowly progressive amyotrophic lateral sclerosis (ALS). Methods: Patients with slowly progressive ALS and at least 1 clinically unaffected limb were prospectively enrolled. Clinical signs of LMN loss and results from hand-held dynamometer (HHD), revised ALS Functional Rating Scale (ALSFRS-R), mean-MUNIX (from 3 different muscles), and NI were longitudinally recorded. Results: Eighteen patients with 43 presymptomatic muscles were evaluated. Twenty-seven muscles remained clinically unaffected during study, with stable ALSFRS-R subscores and HHD measures. However, a significant decline in mean-MUNIX and NI was detected. Discussion: Mean-MUNIX and NI were more sensitive than clinical measures at detecting LMN loss in presymptomatic limbs from patients with slowly progressive ALS. Therefore, these electrophysiological biomarkers should be included in early study phases as meaningful outcome measures. Muscle Nerve 58: 204-212, 2018. (© 2018 Wiley Periodicals, Inc.) |
| التعليقات: | Comment in: Muscle Nerve. 2018 Aug;58(2):184-185. (PMID: 29572875) |
| فهرسة مساهمة: | Keywords: MUNIX*; amyotrophic lateral sclerosis*; biomarker*; lower motor neuron*; motor unit number index*; neurophysiological index* |
| المشرفين على المادة: | 0 (Biomarkers) |
| تواريخ الأحداث: | Date Created: 20180131 Date Completed: 20190422 Latest Revision: 20190422 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1002/mus.26087 |
| PMID: | 29381812 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1097-4598 |
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| DOI: | 10.1002/mus.26087 |