دورية أكاديمية
Interleukin (IL)-23 Stimulates IFN-γ Secretion by CD56 bright Natural Killer Cells and Enhances IL-18-Driven Dendritic Cells Activation.
| العنوان: | Interleukin (IL)-23 Stimulates IFN-γ Secretion by CD56 bright Natural Killer Cells and Enhances IL-18-Driven Dendritic Cells Activation. |
|---|---|
| المؤلفون: | Ziblat A; Instituto de Biología y Medicina Experimental (IBYME-CONICET), Laboratorio de Fisiopatología de la Inmunidad Innata, Buenos Aires, Argentina., Nuñez SY; Instituto de Biología y Medicina Experimental (IBYME-CONICET), Laboratorio de Fisiopatología de la Inmunidad Innata, Buenos Aires, Argentina., Raffo Iraolagoitia XL; Instituto de Biología y Medicina Experimental (IBYME-CONICET), Laboratorio de Fisiopatología de la Inmunidad Innata, Buenos Aires, Argentina., Spallanzani RG; Instituto de Biología y Medicina Experimental (IBYME-CONICET), Laboratorio de Fisiopatología de la Inmunidad Innata, Buenos Aires, Argentina., Torres NI; Instituto de Biología y Medicina Experimental (IBYME-CONICET), Laboratorio de Fisiopatología de la Inmunidad Innata, Buenos Aires, Argentina., Sierra JM; Instituto de Biología y Medicina Experimental (IBYME-CONICET), Laboratorio de Fisiopatología de la Inmunidad Innata, Buenos Aires, Argentina., Secchiari F; Instituto de Biología y Medicina Experimental (IBYME-CONICET), Laboratorio de Fisiopatología de la Inmunidad Innata, Buenos Aires, Argentina., Domaica CI; Instituto de Biología y Medicina Experimental (IBYME-CONICET), Laboratorio de Fisiopatología de la Inmunidad Innata, Buenos Aires, Argentina., Fuertes MB; Instituto de Biología y Medicina Experimental (IBYME-CONICET), Laboratorio de Fisiopatología de la Inmunidad Innata, Buenos Aires, Argentina., Zwirner NW; Instituto de Biología y Medicina Experimental (IBYME-CONICET), Laboratorio de Fisiopatología de la Inmunidad Innata, Buenos Aires, Argentina.; Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina. |
| المصدر: | Frontiers in immunology [Front Immunol] 2018 Jan 17; Vol. 8, pp. 1959. Date of Electronic Publication: 2018 Jan 17 (Print Publication: 2017). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Print ISSN: 1664-3224 (Print) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [Lausanne : Frontiers Research Foundation] |
| مستخلص: | Interleukin (IL)-23 is a member of the IL-12 family of cytokines that, as the other members of this family, is secreted by monocytes, macrophages, and dendritic cells (DC) upon recognition of bacterial, viral, and fungal components. IL-23 is critical during immunity against acute infections, and it is also involved in the development of autoimmune diseases. Although immunoregulatory effects of IL-23 on mouse natural killer (NK) cells have been described, the effect of IL-23 on human NK cells remains ill-defined. In this study, we observed that monocytes stimulated with LPS secreted IL-23 and that blockade of this cytokine during monocyte and NK cell coculture led to a diminished production of IFN-γ by NK cells. Accordingly, rIL-23-induced NK cell activation and stimulated IFN-γ production by CD56 bright NK cells. This effect involved MEK1/MEK2, JNK, PI3K, mammalian target of rapamycin, and NF-κB, but not STAT-1, STAT-3, nor p38 MAPK pathways. Moreover, while NK cell-mediated cytotoxicity remained unaltered, antibody-dependent cellular cytotoxicity (ADCC) was enhanced after IL-23 stimulation. In addition, IL-23 displayed a synergistic effect with IL-18 for IFN-γ production by both CD56 bright and CD56 dim NK cells, and this effect was due to a priming effect of IL-23 for IL-18 responsiveness. Furthermore, NK cells pre-stimulated with IL-18 promoted an increase in CD86 expression and IL-12 secretion by DC treated with LPS, and IL-23 potentiated these effects. Moreover, IL-23-driven enhancement of NK cell "helper" function was dependent on NK cell-derived IFN-γ. Therefore, our results suggest that IL-23 may trigger NK cell-mediated "helper" effects on adaptive immunity, shaping T cell responses during different pathological situations through the regulation of DC maturation. |
| References: | J Exp Med. 2008 Jun 9;205(6):1447-61. (PMID: 18490488) Blood. 2005 Jul 15;106(2):609-16. (PMID: 15802534) Curr Opin Immunol. 2006 Aug;18(4):391-8. (PMID: 16765573) Eur J Dermatol. 2010 Nov-Dec;20(6):724-30. (PMID: 20959273) J Immunol. 1999 Apr 15;162(8):4511-20. (PMID: 10201989) Eur J Immunol. 1999 Dec;29(12):4022-9. (PMID: 10602012) J Immunol. 2003 Sep 1;171(5):2366-73. (PMID: 12928383) Cytokine. 1999 Nov;11(11):822-30. (PMID: 10547269) Eur J Immunol. 2010 Aug;40(8):2236-47. (PMID: 20458705) Clin Dev Immunol. 2010;2010:null. (PMID: 20885915) J Immunol. 2007 Jun 15;178(12):7571-80. (PMID: 17548592) Cancer Cell Int. 2014 Oct 16;14(1):104. (PMID: 25349535) J Immunol. 2006 Jun 15;176(12):7768-74. (PMID: 16751425) Blood. 2005 Jul 15;106(2):566-71. (PMID: 15784725) J Leukoc Biol. 2012 Feb;91(2):321-31. (PMID: 22124136) J Exp Med. 2002 Feb 4;195(3):327-33. (PMID: 11828007) Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4560-5. (PMID: 15070757) J Immunol. 1999 Dec 15;163(12):6365-70. (PMID: 10586025) Nephrol Dial Transplant. 2010 Jul;25(7):2209-17. (PMID: 20100727) Blood. 2005 Oct 1;106(7):2252-8. (PMID: 15933055) Cell Host Microbe. 2009 Dec 17;6(6):503-12. (PMID: 20006839) Proc Natl Acad Sci U S A. 2004 Nov 23;101(47):16606-11. (PMID: 15536127) Blood. 2008 Apr 15;111(8):4173-83. (PMID: 18174382) J Exp Med. 2002 Feb 4;195(3):343-51. (PMID: 11828009) Cancer Immunol Immunother. 2006 Nov;55(11):1426-31. (PMID: 16676182) Blood. 2008 Aug 1;112(3):461-9. (PMID: 18650461) Proc Natl Acad Sci U S A. 2010 May 4;107(18):8328-33. (PMID: 20404142) Front Immunol. 2014 Apr 23;5:187. (PMID: 24795729) J Exp Med. 2005 Oct 3;202(7):941-53. (PMID: 16203865) J Immunol. 1995 May 15;154(10):5320-30. (PMID: 7730635) Nature. 2006 Jul 27;442(7101):461-5. (PMID: 16688182) Immunity. 2007 Apr;26(4):503-17. (PMID: 17398124) Autoimmun Rev. 2018 Feb;17 (2):142-154. (PMID: 29180124) Eur J Immunol. 2015 Jan;45(1):192-202. (PMID: 25308526) Annu Rev Immunol. 2007;25:221-42. (PMID: 17291186) J Leukoc Biol. 2003 Jan;73(1):49-56. (PMID: 12525561) J Exp Med. 2005 Jan 17;201(2):233-40. (PMID: 15657292) J Exp Med. 2015 Sep 21;212(10):1739-52. (PMID: 26347474) Cancer Res. 2006 Sep 1;66(17):8887-96. (PMID: 16951206) Nature. 2015 Jan 15;517(7534):293-301. (PMID: 25592534) Front Immunol. 2013 Jan 04;3:403. (PMID: 23316194) J Immunol. 2007 Jul 1;179(1):372-81. (PMID: 17579058) Nat Immunol. 2008 May;9(5):503-10. (PMID: 18425107) J Exp Med. 1997 Jun 16;185(12):2053-60. (PMID: 9182676) J Immunol. 2007 Sep 15;179(6):3472-9. (PMID: 17804388) Nat Rev Immunol. 2005 Jul;5(7):521-31. (PMID: 15999093) J Immunol. 1999 Dec 15;163(12):6488-93. (PMID: 10586040) J Immunol. 2002 Jun 1;168(11):5699-708. (PMID: 12023369) J Mol Cell Cardiol. 1998 Apr;30(4):723-31. (PMID: 9602421) Biofactors. 2010 Jul-Aug;36(4):274-88. (PMID: 20623510) Eur J Immunol. 2008 Nov;38(11):2948-51. (PMID: 18979515) Nat Protoc. 2006;1(1):1-6. (PMID: 17406204) Annu Rev Immunol. 1997;15:749-95. (PMID: 9143706) PLoS One. 2011;6(10):e26780. (PMID: 22039549) Immunity. 2000 Nov;13(5):715-25. (PMID: 11114383) Trends Immunol. 2001 Nov;22(11):633-40. (PMID: 11698225) Annu Rev Immunol. 2005;23:225-74. (PMID: 15771571) J Immunol. 2008 Oct 1;181(7):5120-7. (PMID: 18802116) Front Immunol. 2013 Nov 11;4:365. (PMID: 24273539) Blood. 2010 Mar 18;115(11):2167-76. (PMID: 19965656) Front Immunol. 2017 Jan 19;8:25. (PMID: 28154569) Blood. 2004 Nov 15;104(10):3267-75. (PMID: 15242871) J Immunol. 2008 Aug 1;181(3):1627-31. (PMID: 18641298) Crit Rev Oncog. 2014;19(1-2):67-75. (PMID: 24941374) Nat Immunol. 2004 Dec;5(12):1260-5. (PMID: 15531883) Blood. 2008 Sep 1;112(5):1776-83. (PMID: 18579793) J Immunol. 2003 Jul 15;171(2):600-7. (PMID: 12847224) Int Immunol. 2009 Feb;21(2):145-53. (PMID: 19088061) Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):728-32. (PMID: 21187373) |
| فهرسة مساهمة: | Keywords: IFN-γ; dendritic cells; interleukin-18; interleukin-23; natural killer cells |
| تواريخ الأحداث: | Date Created: 20180207 Latest Revision: 20191120 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC5785728 |
| DOI: | 10.3389/fimmu.2017.01959 |
| PMID: | 29403472 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder كن أول من يترك تعليقا!