دورية أكاديمية
The role of mTOR-mediated signaling in the regulation of cellular migration.
| العنوان: | The role of mTOR-mediated signaling in the regulation of cellular migration. |
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| المؤلفون: | Holroyd AK; Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK. Electronic address: Ailsa.Holroyd@glasgow.ac.uk., Michie AM; Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK. Electronic address: Alison.Michie@glasgow.ac.uk. |
| المصدر: | Immunology letters [Immunol Lett] 2018 Apr; Vol. 196, pp. 74-79. Date of Electronic Publication: 2018 Feb 03. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7910006 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0542 (Electronic) Linking ISSN: 01652478 NLM ISO Abbreviation: Immunol Lett Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press. |
| مواضيع طبية MeSH: | B-Lymphocytes/*immunology , Cell Movement/*immunology , Signal Transduction/*immunology , TOR Serine-Threonine Kinases/*immunology, B-Lymphocytes/drug effects ; B-Lymphocytes/pathology ; Cell Movement/drug effects ; Humans ; Immunosuppressive Agents/pharmacology ; Leukemia, Lymphocytic, Chronic, B-Cell/immunology ; Leukemia, Lymphocytic, Chronic, B-Cell/metabolism ; Models, Immunological ; Morpholines/pharmacology ; Signal Transduction/drug effects ; Sirolimus/pharmacology ; TOR Serine-Threonine Kinases/antagonists & inhibitors ; TOR Serine-Threonine Kinases/metabolism |
| مستخلص: | Mechanistic target for rapamycin (mTOR) is a serine/threonine protein kinase that forms two distinct complexes mTORC1 and mTORC2, integrating mitogen and nutrient signals to regulate cell survival and proliferation; processes which are commonly deregulated in human cancers. mTORC1 and mTORC2 have divergent molecular associations and cellular functions: mTORC1 regulates in mRNA translation and protein synthesis, while mTORC2 is involved in the regulation of cellular survival and metabolism. Through AKT phosphorylation/activation, mTORC2 has also been reported to regulate cell migration. Recent attention has focused on the aberrant activation of the PI3K/mTOR pathway in B cell malignancies and there is growing evidence for its involvement in disease pathogenesis, due to its location downstream of other established novel drug targets that intercept B cell receptor (BCR) signals. Shared pharmacological features of BCR signal inhibitors include a striking "lymphocyte redistribution" effect whereby patients experience a sharp increase in lymphocyte count on initiation of therapy followed by a steady decline. Chronic lymphocytic leukemia (CLL) serves as a paradigm for migration studies as lymphocytes are among the most widely travelled cells in the body, a product of their role in immunological surveillance. The subversion of normal lymphocyte movement in CLL is being elucidated; this review aims to describe the migration impairment which occurs as part of the wider context of cancer cell migration defects, with a focus on the role of mTOR in mediating migration effects downstream of BCR ligation and other microenvironmental signals. (Copyright © 2018 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved.) |
| معلومات مُعتمدة: | MR/K014854/1 United Kingdom MRC_ Medical Research Council |
| فهرسة مساهمة: | Keywords: AKT; Chronic lymphocytic leukemia; Lymphocytosis; Migration; mTOR kinase |
| المشرفين على المادة: | 0 (Immunosuppressive Agents) 0 (Morpholines) 970JJ37FPW ((5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol) EC 2.7.1.1 (MTOR protein, human) EC 2.7.11.1 (TOR Serine-Threonine Kinases) W36ZG6FT64 (Sirolimus) |
| تواريخ الأحداث: | Date Created: 20180207 Date Completed: 20190325 Latest Revision: 20220129 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1016/j.imlet.2018.01.015 |
| PMID: | 29408410 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1879-0542 |
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| DOI: | 10.1016/j.imlet.2018.01.015 |