دورية أكاديمية
أعرض في EDS

Investigating miRNA-661 and ATG4-B mRNA expression as potential biomarkers for hepatocellular carcinoma.

التفاصيل البيبلوغرافية
العنوان: Investigating miRNA-661 and ATG4-B mRNA expression as potential biomarkers for hepatocellular carcinoma.
المؤلفون: Ali MA; Department of Biomedical Research, Armed Forces College of Medicine (AFCM), Cairo, 11774, Egypt., Matboli M; Department of Medical Biochemistry & Molecular Biology, Ain Shams Faculty of Medicine Research Center (Masri), 11778, Eygpt., El-Khazragy N; Department of Clinical Pathology, Oncology Diagnostic Unit, Faculty of Medicine, Ain Shams University, Cairo, 11778, Egypt., Saber O; Armed Forces College of Medicine (AFCM), Cairo, 11774, Egypt., El-Nakeep S; Hepatology & Gastroenterology Unit, Internal Medicine Department, Faculty of Medicine, Ain Shams University, Cairo, 11778, Egypt., Abdelzaher HM; Faculty of Biotechnology, October University for Modern Sciences & Arts, Cairo, 12585, Egypt., Shafei AE; Department of Biomedical Research, Armed Forces College of Medicine (AFCM), Cairo, 11774, Egypt., Mostafa R; Department of Biomedical Research, Armed Forces College of Medicine (AFCM), Cairo, 11774, Egypt.
المصدر: Biomarkers in medicine [Biomark Med] 2018 Mar; Vol. 12 (3), pp. 245-256. Date of Electronic Publication: 2018 Feb 14.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Future Medicine Country of Publication: England NLM ID: 101312535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1752-0371 (Electronic) Linking ISSN: 17520363 NLM ISO Abbreviation: Biomark Med Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Future Medicine
مواضيع طبية MeSH: Autophagy-Related Proteins/*genetics , Biomarkers, Tumor/*genetics , Carcinoma, Hepatocellular/*diagnosis , Cysteine Endopeptidases/*genetics , Liver Neoplasms/*diagnosis , MicroRNAs/*blood , RNA, Messenger/*blood, Area Under Curve ; Biomarkers, Tumor/metabolism ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/pathology ; Case-Control Studies ; Female ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; Male ; Middle Aged ; Neoplasm Staging ; Prognosis ; ROC Curve ; Up-Regulation
مستخلص: Aim: We aimed to examine the statistical association between serum expression of miRNA 661 (miR-661) and ATG-4B mRNA and hepatocellular carcinoma (HCC) based on in silico data analysis followed by clinical validation.
Patients & Methods: Quantitative reverse-transcriptase real-time PCR was used to examine the expression of miR-661 and ATG-4B mRNA in the sera of HCC patients versus control.
Results: The expression of miR-661 and ATG-4B mRNA was positive in 97.14 and 77.14%, respectively, in HCC patients. The survival analysis showed that ATG-4B mRNA was an independent prognostic factor.
Conclusion: Our data are the first report of its kind regarding the considerable clinical significance of miR-661 and ATG-4B mRNA in HCC patients.
فهرسة مساهمة: Keywords: ATG-4B; bioinformatics; biomarkers; hepatocellular carcinoma; miR-661; prognosis
المشرفين على المادة: 0 (Autophagy-Related Proteins)
0 (Biomarkers, Tumor)
0 (MIRN661 microRNA, human)
0 (MicroRNAs)
0 (RNA, Messenger)
EC 3.4.22.- (ATG4B protein, human)
EC 3.4.22.- (Cysteine Endopeptidases)
تواريخ الأحداث: Date Created: 20180215 Date Completed: 20190524 Latest Revision: 20190524
رمز التحديث: 20240829
DOI: 10.2217/bmm-2017-0273
PMID: 29441798
قاعدة البيانات: MEDLINE
الوصف
تدمد:1752-0371
DOI:10.2217/bmm-2017-0273