دورية أكاديمية
Enhancing the Therapeutic Efficacy of Tamoxifen Citrate Loaded Span-Based Nano-Vesicles on Human Breast Adenocarcinoma Cells.
| العنوان: | Enhancing the Therapeutic Efficacy of Tamoxifen Citrate Loaded Span-Based Nano-Vesicles on Human Breast Adenocarcinoma Cells. |
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| المؤلفون: | Kassem MA; Department of Pharmaceutics and Industrial Pharmacy, Cairo University, Cairo, Egypt., Megahed MA; Department of Pharmaceutics and Pharmaceutical Technology, Egyptian Russian University, Cairo, Egypt., Abu Elyazid SK; Department of Pharmaceutics and Pharmaceutical Technology, Egyptian Russian University, Cairo, Egypt.; Department of Pharmaceutics and Industrial Pharmacy, Al-Azhar University, Cairo, Egypt., Abd-Allah FI; Department of Pharmaceutics and Pharmaceutical Technology, Egyptian Russian University, Cairo, Egypt.; Department of Pharmaceutics and Industrial Pharmacy, Al-Azhar University, Cairo, Egypt., Abdelghany TM; Department of Pharmacology and Toxicology, Al-Azhar University, Cairo, Egypt., Al-Abd AM; Department of Pharmacology and Toxicology, King Abdulaziz University, Jeddah, Saudi Arabia.; Pharmacology Department, Medical Division, National Research Center, Giza, Egypt.; Biomedical Research Section, Nawah Scientific, Cairo, Egypt., El-Say KM; Department of Pharmaceutics and Industrial Pharmacy, Al-Azhar University, Cairo, Egypt. kelsay1@kau.edu.sa.; Department of Pharmaceutics, King Abdulaziz University, Jeddah, Saudi Arabia. kelsay1@kau.edu.sa. |
| المصدر: | AAPS PharmSciTech [AAPS PharmSciTech] 2018 May; Vol. 19 (4), pp. 1529-1543. Date of Electronic Publication: 2018 Feb 22. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: United States NLM ID: 100960111 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-9932 (Electronic) Linking ISSN: 15309932 NLM ISO Abbreviation: AAPS PharmSciTech Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York : Springer Original Publication: Arlington, VA : American Association of Pharmaceutical Scientists, c2000- |
| مواضيع طبية MeSH: | Adenocarcinoma/*metabolism , Breast Neoplasms/*metabolism , Drug Carriers/*metabolism , Nanoparticles/*metabolism , Tamoxifen/*metabolism, Adenocarcinoma/drug therapy ; Adenocarcinoma/pathology ; Animals ; Antineoplastic Agents, Hormonal/administration & dosage ; Antineoplastic Agents, Hormonal/chemistry ; Antineoplastic Agents, Hormonal/metabolism ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Cell Survival/drug effects ; Cell Survival/physiology ; Cricetinae ; Dose-Response Relationship, Drug ; Drug Carriers/administration & dosage ; Drug Carriers/chemistry ; Female ; Humans ; MCF-7 Cells ; Nanoparticles/administration & dosage ; Nanoparticles/chemistry ; Particle Size ; Tamoxifen/administration & dosage ; Tamoxifen/chemistry ; Treatment Outcome |
| مستخلص: | Serious adverse effects and low selectivity to cancer cells are the main obstacles of long term therapy with Tamoxifen (Tmx). This study aimed to develop Tmx-loaded span-based nano-vesicles for delivery to malignant tissues with maximum efficacy. The effect of three variables on vesicle size (Y |
| فهرسة مساهمة: | Keywords: Box-Behnken design; Breast cancer cells; In vitro cytotoxicity; Optimization; Tamoxifen citrate |
| المشرفين على المادة: | 0 (Antineoplastic Agents, Hormonal) 0 (Drug Carriers) 094ZI81Y45 (Tamoxifen) |
| تواريخ الأحداث: | Date Created: 20180223 Date Completed: 20180829 Latest Revision: 20181202 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1208/s12249-018-0962-y |
| PMID: | 29470829 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1530-9932 |
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| DOI: | 10.1208/s12249-018-0962-y |