دورية أكاديمية
Chemical characterisation of Piper amalago (Piperaceae) essential oil by comprehensive two-dimensional gas chromatography coupled with rapid-scanning quadrupole mass spectrometry (GC×GC/qMS) and their antilithiasic activity and acute toxicity.
| العنوان: | Chemical characterisation of Piper amalago (Piperaceae) essential oil by comprehensive two-dimensional gas chromatography coupled with rapid-scanning quadrupole mass spectrometry (GC×GC/qMS) and their antilithiasic activity and acute toxicity. |
|---|---|
| المؤلفون: | Dos Santos AL; Instituto de Química, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil., Novaes ADS; Hospital da Universidade Federal da Grande Dourados, Dourados, MS, Brazil., Polidoro ADS; Instituto de Química, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil., de Barros ME; Hospital da Universidade Federal da Grande Dourados, Dourados, MS, Brazil.; Faculdade de Ciências da Saúde, Universidade Federal da Grande Dourados, Dourados, MS, Brazil., Mota JS; Centro de Estudos em Recursos Naturais, Universidade Estadual do Mato Grosso do Sul, Dourados, MS, Brazil., Lima DBM; Departamento de Biotecnologia Industrial, Universidade Tiradentes, Aracaju, SE, Brazil., Krause LC; Departamento de Biotecnologia Industrial, Universidade Tiradentes, Aracaju, SE, Brazil., Cardoso CAL; Centro de Estudos em Recursos Naturais, Universidade Estadual do Mato Grosso do Sul, Dourados, MS, Brazil., Jacques RA; Instituto de Química, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil., Caramão EB; Instituto de Química, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.; Departamento de Biotecnologia Industrial, Universidade Tiradentes, Aracaju, SE, Brazil.; Instituto Nacional de Ciências e Tecnologia - Energia e Meio Ambiente, Salvador, BA, Brazil. |
| المصدر: | Phytochemical analysis : PCA [Phytochem Anal] 2018 Sep; Vol. 29 (5), pp. 432-445. Date of Electronic Publication: 2018 Feb 26. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley Country of Publication: England NLM ID: 9200492 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-1565 (Electronic) Linking ISSN: 09580344 NLM ISO Abbreviation: Phytochem Anal Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Chichester, Sussex, UK : Wiley, c1990- |
| مواضيع طبية MeSH: | Gas Chromatography-Mass Spectrometry/*methods , Kidney Calculi/*drug therapy , Oils, Volatile/*chemistry , Oils, Volatile/*therapeutic use , Piper/*chemistry, Administration, Oral ; Animals ; Calcium Oxalate/chemistry ; Crystallization ; Humans ; Oils, Volatile/administration & dosage ; Oils, Volatile/toxicity ; Plant Leaves/chemistry ; Plant Stems/chemistry ; Rats, Wistar ; Toxicity Tests, Acute |
| مستخلص: | Introduction: Piper amalago has a distribution from Mexico to Brazil; their aerial parts have been used in folk medicine to treat diuretic and kidney diseases. Objective: The purpose of this study was to obtain a deeper understanding of the chemical composition of essential oils (EOs) extracted from both the leaves and stems of P. amalago, compare them, and evaluate their antilithiasic activity and acute toxicity. Methodology: Extraction was performed by hydrodistillation, whereas chemical characterisation by two-dimensional gas chromatography coupled with rapid-scanning quadrupole mass spectrometry (GC×GC/qMS). The antilithiasic activity was evaluated by the effect of the EOs on calcium oxalate crystallisation in vitro. The turbidity index and the number of crystals formed were determined and used as an estimative of the activity. In the acute toxicity assay, the effects of a single oral dose of the EOs in Wistar rats were determined. General behaviour, adverse effects, and mortality were determined. Results: A total of 322 compounds were identified in the EOs. The sesquiterpenes displayed the highest contribution in leaves EOs among which included bicyclogermacrene and δ-cadinene. Sesquiterpenes and oxygenated sesquiterpenes displayed the highest contribution in EOs from stems, among which included bicyclogermacrene and α-cadinol. The EOs demonstrated an excellent action on the crystals growth inhibition, and the oral dose tested did not induce significant changes in the parameters for acute toxicity. Conclusion: The oils have a high chemical complexity, and there are differences between their compositions, which could explain the observed differences in antilithiasic activity. The findings support the use of this plant in folk medicine to treat kidney diseases. (Copyright © 2018 John Wiley & Sons, Ltd.) |
| فهرسة مساهمة: | Keywords: Piper amalago; antilithiasic activity; antioxidant activity; comprehensive two-dimensional gas chromatography; essential oil; mass spectrometry |
| المشرفين على المادة: | 0 (Oils, Volatile) 2612HC57YE (Calcium Oxalate) |
| تواريخ الأحداث: | Date Created: 20180227 Date Completed: 20181105 Latest Revision: 20181105 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1002/pca.2747 |
| PMID: | 29479742 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1099-1565 |
|---|---|
| DOI: | 10.1002/pca.2747 |