دورية أكاديمية
[The effect of 3,5-dicarbomethoxyphenylbiguanide on the activity of antioxidant enzymes].
| العنوان: | [The effect of 3,5-dicarbomethoxyphenylbiguanide on the activity of antioxidant enzymes]. |
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| المؤلفون: | Safonova OA, Popova TN, Krylskiy ED, Agarkov AA, Shulgin KK, Kirilova EM, Tanygina ES |
| المصدر: | Prikladnaia biokhimiia i mikrobiologiia [Prikl Biokhim Mikrobiol] 2016 Jul-Aug; Vol. 52 (4), pp. 416-20. |
| نوع المنشور: | Journal Article |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: Izdatelstvo Nauka Country of Publication: Russia (Federation) NLM ID: 0023416 Publication Model: Print Cited Medium: Print ISSN: 0555-1099 (Print) Linking ISSN: 05551099 NLM ISO Abbreviation: Prikl Biokhim Mikrobiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Moskva : Izdatelstvo Nauka |
| مواضيع طبية MeSH: | Antioxidants/*chemistry , Guanidines/*chemistry , Oxidoreductases/*chemistry, Animals ; Enzyme Activation ; Rats |
| مستخلص: | The effect of 3,5-dicarbomethoxyphenylbiguanide, which was selected with the Prediction of Activity Spectra of Substances (PASS) computer program, on the activity of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glutathione transferase in the heart and the blood serum of rats with experimental rheumatoid arthritis was investigated. The studied parameters changed towards control values when the tested compound was injected in animals with the pathology. These results can be explained by the cardioprotective and antioxidant activity of the compound. The data obtained during the study may be used for the development of new preventive and therapeutic agents for the treatment of the rheumatoid arthritis. |
| المشرفين على المادة: | 0 (Antioxidants) 0 (Guanidines) EC 1.- (Oxidoreductases) |
| تواريخ الأحداث: | Date Created: 20180308 Date Completed: 20180326 Latest Revision: 20180326 |
| رمز التحديث: | 20231215 |
| PMID: | 29512987 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0555-1099 |
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