دورية أكاديمية
أعرض في EDS

Factors associated with bronchiectasis in patients with uncontrolled asthma; the NOPES score: a study in 398 patients.

التفاصيل البيبلوغرافية
العنوان: Factors associated with bronchiectasis in patients with uncontrolled asthma; the NOPES score: a study in 398 patients.
المؤلفون: Padilla-Galo A; Pneumology Unit. Agencia Sanitaria Costa del Sol, Carretera Nacional 340, Km 187, 29603, Marbella, Málaga, Spain., Olveira C; Pneumology Department, IBIMA (Institute for biomedical research of Málaga), Hospital Regional Universitario de Málaga/ University of Málaga, Avenida Carlos Haya, 29010, Málaga, Spain. casi1547@separ.es., Fernández de Rota-Garcia L; Pneumology Unit. Agencia Sanitaria Costa del Sol, Carretera Nacional 340, Km 187, 29603, Marbella, Málaga, Spain., Marco-Galve I; Radiology Deparment. Hospital de Alta Resolución de Benalmádena, Arroyo Hondo s/n, 29639, Benalmádena, Málaga, Spain., Plata AJ; Infectious Diseases Department, Hospital Regional Universitario de Málaga, Avenida Carlos Haya, 29010, Málaga, Spain., Alvarez A; Radiology Deparment. Hospital de Alta Resolución de Benalmádena, Arroyo Hondo s/n, 29639, Benalmádena, Málaga, Spain., Rivas-Ruiz F; Research Unit. Red de Investigación en Servicios de Salud en Enfermedades Crónicas, REDISSEC (Spanish healthcare network for chronic diseases), Agencia Sanitaria Costa del Sol, Carretera Nacional 340, Km 187, 29603, Marbella, Málaga, Spain., Carmona-Olveira A; Faculty of Medicine, University of Málaga, Málaga, Spain., Cebrian-Gallardo JJ; Pneumology Unit. Agencia Sanitaria Costa del Sol, Carretera Nacional 340, Km 187, 29603, Marbella, Málaga, Spain., Martinez-Garcia MA; Pneumology Department, Hospital Universitario La Fe, Valencia, Spain.
المصدر: Respiratory research [Respir Res] 2018 Mar 16; Vol. 19 (1), pp. 43. Date of Electronic Publication: 2018 Mar 16.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101090633 Publication Model: Electronic Cited Medium: Internet ISSN: 1465-993X (Electronic) Linking ISSN: 14659921 NLM ISO Abbreviation: Respir Res Subsets: MEDLINE
أسماء مطبوعة: Publication: 2001- : London : BioMed Central Ltd.
Original Publication: London : Current Science Ltd., c2000-
مواضيع طبية MeSH: Severity of Illness Index*, Asthma/*diagnosis , Asthma/*physiopathology , Bronchiectasis/*diagnosis , Bronchiectasis/*physiopathology, Adult ; Aged ; Asthma/epidemiology ; Breath Tests/methods ; Bronchiectasis/epidemiology ; Female ; Follow-Up Studies ; Forced Expiratory Volume/physiology ; Humans ; Male ; Middle Aged ; Prospective Studies ; Sputum/physiology
مستخلص: Background: Some studies have reported a high prevalence of bronchiectasis in patients with uncontrolled asthma, but the factors associated with this condition are unknown. The objective of this study was to determine the prevalence of bronchiectasis in uncontrolled moderate-to-severe asthma and to identify risk factors and their correlation with bronchiectasis in these patients.
Methods: This is a prospective study of data from consecutive patients with uncontrolled moderate-to-severe asthma. Diagnosis of bronchiectasis was based on high-resolution computed tomography. A prognostic score was developed using a logistic regression model, which was used to determine the factors associated with bronchiectasis.
Results: A total of 398 patients (60% with severe asthma) were included. The prevalence of bronchiectasis was 28.4%. The presence of bronchiectasis was associated with a higher frequency of chronic expectoration (OR, 2.95; 95% CI, 1.49-5.84; p = 0.002), greater severity of asthma (OR, 2.43; 95% CI, 1.29-4.57; p = 0.006), at least one previous episode of pneumonia (OR, 2.42; 95% CI, 1.03-5.69; p = 0.044), and lower levels of FeNO (OR, 0.98; 95% CI, 0.97-0.99; p = 0.016). The NOPES score was developed on the basis of these variables (FeNO[cut off point 20.5 ppb], Pneumonia, Expectoration and asthma Severity), and it ranges from 0 to 4 points, where 0 means "no risk" and 4 corresponds to "high risk". The NOPES score yielded an AUC-ROC of 70% for the diagnosis of bronchiectasis, with a specificity of 95%.
Conclusions: Almost a third of the patients with uncontrolled moderate-to-severe asthma had bronchiectasis. Bronchiectasis was related to the severity of asthma, the presence of chronic expectoration, a previous history of pneumonia, and lower levels of FeNO. The NOPES score is an easy-to-use scoring system with a high prognostic value for bronchiectasis in patients with uncontrolled moderate-to-severe asthma.
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فهرسة مساهمة: Keywords: Asthma; Bronchiectasis; NOPES; Prevalence; Risk factors
تواريخ الأحداث: Date Created: 20180318 Date Completed: 20181112 Latest Revision: 20240314
رمز التحديث: 20240314
مُعرف محوري في PubMed: PMC5857069
DOI: 10.1186/s12931-018-0746-7
PMID: 29548297
قاعدة البيانات: MEDLINE
الوصف
تدمد:1465-993X
DOI:10.1186/s12931-018-0746-7