دورية أكاديمية
Nutritional Support from the Intestinal Microbiota Improves Hematopoietic Reconstitution after Bone Marrow Transplantation in Mice.
| العنوان: | Nutritional Support from the Intestinal Microbiota Improves Hematopoietic Reconstitution after Bone Marrow Transplantation in Mice. |
|---|---|
| المؤلفون: | Staffas A; Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Burgos da Silva M; Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Slingerland AE; Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Lazrak A; Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Bare CJ; Joan and Sanford I. Weill Department of Medicine, Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, NY 10021, USA., Holman CD; Joan and Sanford I. Weill Department of Medicine, Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, NY 10021, USA., Docampo MD; Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Immunology and Microbial Pathogenesis, Weill Cornell Medical College, New York, NY 10065, USA., Shono Y; Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Durham B; Human Oncology and Pathogenesis Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Pickard AJ; Donald B. and Catherine C. Marron Cancer Metabolism Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Cross JR; Donald B. and Catherine C. Marron Cancer Metabolism Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Stein-Thoeringer C; Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Velardi E; Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Tsai JJ; Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Jahn L; Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Jay H; Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Lieberman S; Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Smith OM; Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Pamer EG; Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Weill Cornell Medical College, New York, NY 10065, USA; Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Lucille Castori Center for Microbes, Inflammation, and Cancer, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Peled JU; Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Weill Cornell Medical College, New York, NY 10065, USA; Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Cohen DE; Joan and Sanford I. Weill Department of Medicine, Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, NY 10021, USA., Jenq RR; Departments of Genomic Medicine and Stem Cell Transplantation Cellular Therapy, Division of Cancer Medicine, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA., van den Brink MRM; Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Weill Cornell Medical College, New York, NY 10065, USA; Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: vandenbm@mskcc.org. |
| المصدر: | Cell host & microbe [Cell Host Microbe] 2018 Apr 11; Vol. 23 (4), pp. 447-457.e4. Date of Electronic Publication: 2018 Mar 22. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 101302316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1934-6069 (Electronic) Linking ISSN: 19313128 NLM ISO Abbreviation: Cell Host Microbe Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge, Mass. : Cell Press |
| مواضيع طبية MeSH: | Bone Marrow Transplantation* , Gastrointestinal Microbiome* , Nutritional Support*, Animals ; Bone Marrow/physiology ; Hematopoiesis ; Mice ; Models, Animal ; Treatment Outcome |
| مستخلص: | Bone marrow transplantation (BMT) offers curative potential for patients with high-risk hematologic malignancies, but the post-transplantation period is characterized by profound immunodeficiency. Recent studies indicate that the intestinal microbiota not only regulates mucosal immunity, but can also contribute to systemic immunity and hematopoiesis. Using antibiotic-mediated microbiota depletion in a syngeneic BMT mouse model, here we describe a role for the intestinal flora in hematopoietic recovery after BMT. Depletion of the intestinal microbiota resulted in impaired recovery of lymphocyte and neutrophil counts, while recovery of the hematopoietic stem and progenitor compartments and the erythroid lineage were largely unaffected. Depletion of the intestinal microbiota also reduced dietary energy uptake and visceral fat stores. Caloric supplementation through sucrose in the drinking water improved post-BMT hematopoietic recovery in mice with a depleted intestinal flora. Taken together, we show that the intestinal microbiota contribute to post-BMT hematopoietic reconstitution in mice through improved dietary energy uptake. (Copyright © 2018 Elsevier Inc. All rights reserved.) |
| التعليقات: | Comment in: Cell Host Microbe. 2018 Apr 11;23 (4):423-424. (PMID: 29649435) |
| References: | Br J Haematol. 2004 Apr;125(2):217-24. (PMID: 15059145) Nat Med. 2014 May;20(5):524-30. (PMID: 24747744) Life Sci. 1999;64(19):1733-8. (PMID: 10353627) Cell. 2014 Mar 27;157(1):121-41. (PMID: 24679531) Eur J Haematol. 2014 Oct;93(4):273-80. (PMID: 24725056) Acta Pharmacol Toxicol (Copenh). 1981 Jul;49(1):38-42. (PMID: 7336963) Nucleic Acids Res. 2014 Jan;42(Database issue):D490-5. (PMID: 24270786) J Immunol. 2014 Nov 15;193(10):5273-83. (PMID: 25305320) Nat Med. 2015 Dec;21(12):1497-1501. (PMID: 26569380) Cell Host Microbe. 2017 May 10;21(5):592-602.e4. (PMID: 28494240) Clin Exp Med. 2004 Oct;4(2):78-85. (PMID: 15672944) Nutr Res. 2017 Mar;39:43-50. (PMID: 28385288) Radiat Res. 2010 Apr;173(4):557-78. (PMID: 20334528) J Radiat Res. 2015 Mar;56(2):278-86. (PMID: 25617317) Front Nutr. 2016 Apr 19;3:10. (PMID: 27148535) Appl Environ Microbiol. 2009 Dec;75(23):7537-41. (PMID: 19801464) Blood. 2004 Jan 1;103(1):340-6. (PMID: 12969972) Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15718-23. (PMID: 15505215) Science. 2017 Sep 1;357(6354):912-916. (PMID: 28860383) Am J Physiol. 1958 Mar;192(3):549-56. (PMID: 13520954) J Exp Med. 1968 Jul 1;128(1):97-110. (PMID: 5662019) J Exp Biol. 2014 Jun 1;217(Pt 11):1894-901. (PMID: 24577449) Blood. 2014 Aug 14;124(7):1174-82. (PMID: 24939656) Bone Marrow Transplant. 2008 Feb;41(3):245-52. (PMID: 17952129) Cell Metab. 2015 Nov 3;22(5):886-94. (PMID: 26387866) Blood. 2017 Feb 9;129(6):729-739. (PMID: 27879260) Physiol Rev. 1990 Apr;70(2):567-90. (PMID: 2181501) BMC Bioinformatics. 2006 Aug 07;7:371. (PMID: 16893466) Bone Marrow Transplant. 2005 Jun;35(12):1171-7. (PMID: 15880127) Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E316-26. (PMID: 17426110) Trials. 2015 Apr 07;16:136. (PMID: 25872934) Lancet. 1978 Jul 29;2(8083):226-8. (PMID: 79026) Nature. 2009 Jan 22;457(7228):480-4. (PMID: 19043404) Science. 2005 Mar 25;307(5717):1915-20. (PMID: 15790844) Physiol Behav. 2005 Aug 7;85(5):546-56. (PMID: 15996693) Cell Immunol. 1996 Oct 10;173(1):155-61. (PMID: 8871611) Science. 2008 Apr 11;320(5873):226-30. (PMID: 18403709) J Appl Physiol Respir Environ Exerc Physiol. 1983 Aug;55(2):628-34. (PMID: 6618956) Res Dev Tech Rep. 1967 Jan 11;:1-20. (PMID: 5298226) J Physiol. 1949 Aug;109(1-2):1-9. (PMID: 15394301) Infect Immun. 1981 Sep;33(3):854-61. (PMID: 6456996) J Clin Oncol. 2017 May 20;35(15):1650-1659. (PMID: 28296584) PLoS One. 2011;6(12):e27310. (PMID: 22194782) J Vet Pharmacol Ther. 2002 Feb;25(1):1-5. (PMID: 11874520) J Antimicrob Chemother. 1994 Jan;33(1):63-72. (PMID: 8157575) Nat Med. 2010 Feb;16(2):228-31. (PMID: 20081863) Nat Rev Microbiol. 2013 Jul;11(7):497-504. (PMID: 23748339) Br J Haematol. 2001 Dec;115(3):630-41. (PMID: 11736948) Blood. 1999 Jan 15;93(2):467-80. (PMID: 9885208) Arch Dis Child. 1996 Sep;75(3):208-13. (PMID: 8976659) J Exp Med. 2016 Apr 4;213(4):535-53. (PMID: 26951333) Cell Host Microbe. 2013 Nov 13;14(5):582-90. (PMID: 24237703) J Exp Med. 1965 Jul 1;122:77-82. (PMID: 14325475) Blood. 2017 Jan 12;129(2):171-176. (PMID: 27799160) Bone Marrow Transplant. 1998 Dec;22(12):1171-8. (PMID: 9894720) Blood. 1998 Sep 1;92(5):1471-90. (PMID: 9716573) Bone Marrow Transplant. 2017 Apr;52(4):506-513. (PMID: 28067888) Cell Host Microbe. 2014 Mar 12;15(3):374-81. (PMID: 24629343) Leuk Lymphoma. 2017 Aug;58(8):1859-1871. (PMID: 28073320) Cell. 2005 Jul 15;122(1):107-18. (PMID: 16009137) |
| معلومات مُعتمدة: | R01 AI101406 United States AI NIAID NIH HHS; R01 HL069929 United States HL NHLBI NIH HHS; R01 HL124112 United States HL NHLBI NIH HHS; R01 DK103046 United States DK NIDDK NIH HHS; R01 AI080455 United States AI NIAID NIH HHS; U01 AI124275 United States AI NIAID NIH HHS; R29 DK048873 United States DK NIDDK NIH HHS; P30 CA008748 United States CA NCI NIH HHS; R37 DK048873 United States DK NIDDK NIH HHS; R01 DK048873 United States DK NIDDK NIH HHS; R01 AI100288 United States AI NIAID NIH HHS; R01 DK056626 United States DK NIDDK NIH HHS; P01 CA023766 United States CA NCI NIH HHS |
| فهرسة مساهمة: | Keywords: antibiotics; bone marrow cell transplantation; hematopoiesis; hematopoietic recovery; immune reconstitution; intestinal flora; microbiota; nutrition |
| تواريخ الأحداث: | Date Created: 20180327 Date Completed: 20180919 Latest Revision: 20231112 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC5897172 |
| DOI: | 10.1016/j.chom.2018.03.002 |
| PMID: | 29576480 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1934-6069 |
|---|---|
| DOI: | 10.1016/j.chom.2018.03.002 |