دورية أكاديمية
Individual data meta-analysis for the study of survival after pulmonary metastasectomy in colorectal cancer patients: A history of resected liver metastases worsens the prognosis.
| العنوان: | Individual data meta-analysis for the study of survival after pulmonary metastasectomy in colorectal cancer patients: A history of resected liver metastases worsens the prognosis. |
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| المؤلفون: | Zabaleta J; Thoracic Surgery Service, Hospital Universitario Donostia, Paseo Dr Beguiristain s/n, Donostia, 20014, Gipuzkoa, Spain. Electronic address: jon.zabaletajimenez@osakidetza.eus., Iida T; Department of Thoracic Surgery, Kimitsu Central Hospital, Chiba, Japan., Falcoz PE; Department of Thoracic Surgery, Strasbourg University Hospital, Strasbourg, France., Salah S; Medical Oncology Department, King Hussein Cancer Center, Amman, Jordan., Jarabo JR; Department of Thoracic Surgery, Hospital Clínico San Carlos, Madrid, Spain., Correa AM; Department of Thoracic and Cardiovascular Surgery, University of Texas MD Anderson Cancer Center, Houston, USA., Zampino MG; Unit of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, Milan, Italy., Matsui T; Department of Colorectal Surgery, Tochigi Cancer Center, Tochigi, Japan., Cho S; Department of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital, Seoul, South Korea. Electronic address: skcho@snubh.org., Ardissone F; Department of Oncology, Unit of Thoraic Surgery, University of Torino, Italy., Watanabe K; Department of Surgical Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan., Gonzalez M; Service de Chirurgie Thoracique, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland., Gervaz P; Department of Surgery, University Hospital Geneva, Geneva, Switzerland., Emparanza JI; Clinical Epidemiology Unit, Hospital Universitario Donostia, UPV/EHU, CIBER-ESP, CASPe, Biodonostia, Donostia, Spain., Abraira V; Unidad de Bioestadística Clínica, Hospital Universitario Ramón y Cajal, IRYCIS, CIBER-ESP, Madrid, Spain. |
| المصدر: | European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology [Eur J Surg Oncol] 2018 Jul; Vol. 44 (7), pp. 1006-1012. Date of Electronic Publication: 2018 Mar 21. |
| نوع المنشور: | Journal Article; Meta-Analysis |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 8504356 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2157 (Electronic) Linking ISSN: 07487983 NLM ISO Abbreviation: Eur J Surg Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Original Publication: London ; New York : Academic Press, [1985- |
| مواضيع طبية MeSH: | Metastasectomy* , Pneumonectomy*, Colorectal Neoplasms/*pathology , Liver Neoplasms/*surgery , Lung Neoplasms/*surgery, Aged ; Carcinoembryonic Antigen/blood ; Colorectal Neoplasms/mortality ; Disease-Free Survival ; Female ; Hepatectomy ; Humans ; Liver Neoplasms/secondary ; Lung Neoplasms/secondary ; Lymph Nodes/pathology ; Male ; Margins of Excision ; Middle Aged ; Prognosis ; Proportional Hazards Models ; Risk Factors ; Survival Rate ; Thoracic Surgery, Video-Assisted ; Tumor Burden |
| مستخلص: | Objectives: To assess the impact of a history of liver metastases on survival in patients undergoing surgery for lung metastases from colorectal carcinoma. Methods: We reviewed recent studies identified by searching MEDLINE and EMBASE using the Ovid interface, with the following search terms: lung metastasectomy, pulmonary metastasectomy, lung metastases and lung metastasis, supplemented by manual searching. Inclusion criteria were that the research concerned patients with lung metastases from colorectal cancer undergoing surgery with curative intent, and had been published between 2007 and 2014. Exclusion criteria were that the paper was a review, concerned surgical techniques themselves (without follow-up), and included patients treated non-surgically. Using Stata 14, we performed aggregate data and individual data meta-analysis using random-effect and Cox multilevel models respectively. Results: We collected data on 3501 patients from 17 studies. The overall median survival was 43 months. In aggregate data meta-analysis, the hazard ratio for patients with previous liver metastases was 1.19 (95% CI 0.90-1.47), with low heterogeneity (I 2 4.3%). In individual data meta-analysis, the hazard ratio for these patients was 1.37 (95% CI 1.14-1.64; p < 0.001). Multivariate analysis identified the following factors significantly affecting survival: tumour-infiltrated pulmonary lymph nodes (p < 0.001), type of resection (p = 0.005), margins (p < 0.001), carcinoembryonic antigen levels (p < 0.001), and number and size of lung metastases (both p < 0.001). Conclusions: A history of liver metastases is a negative prognostic factor for survival in patients with lung metastases from colorectal cancer. We registered the meta-analysis protocol in PROSPERO (CRD42015017838). (Copyright © 2018 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Colorectal cancer; Individual data meta-analysis; Liver; Lung; Metastasis; Survival |
| المشرفين على المادة: | 0 (Carcinoembryonic Antigen) |
| تواريخ الأحداث: | Date Created: 20180401 Date Completed: 20180709 Latest Revision: 20180709 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.ejso.2018.03.011 |
| PMID: | 29602524 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1532-2157 |
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| DOI: | 10.1016/j.ejso.2018.03.011 |