دورية أكاديمية
Appendiceal carcinoma associated with microsatellite instability.
| العنوان: | Appendiceal carcinoma associated with microsatellite instability. |
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| المؤلفون: | Morales-Miranda A; Department of Reproductive Biology, National Institute of Medical Sciences and Nutrition Salvador Zubirán, Mexico City 14080, Mexico., Rosado ID; Department of Surgery, National Institute of Medical Sciences and Nutrition Salvador Zubirán, Mexico City 14080, Mexico., Núñez CC; Department of Surgery, National Institute of Medical Sciences and Nutrition Salvador Zubirán, Mexico City 14080, Mexico., Montero FC; Department of Pathology, Hospital Médica Sur, Mexico City 14080, Mexico. |
| المصدر: | Molecular and clinical oncology [Mol Clin Oncol] 2018 May; Vol. 8 (5), pp. 694-698. Date of Electronic Publication: 2018 Mar 26. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Spandidos Publications UK Ltd Country of Publication: England NLM ID: 101613422 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2049-9450 (Print) Linking ISSN: 20499450 NLM ISO Abbreviation: Mol Clin Oncol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: London, UK : Spandidos Publications UK Ltd |
| مستخلص: | Approximately 15% of colorectal cancer (CRC) cases exhibit microsatellite instability (MSI), which appears to be associated with unique biological behavior. The present study presents a case of appendiceal carcinoma associated with MSI that responded well to adjuvant chemotherapy. Clinical, pathological and immunohistochemical (IHC) characteristics have been described. The 60-year-old male patient had suffered from recurrent lower abdominal pain associated with abdominal distention for 6 months; then, following an acute attack, he was subjected to laparoscopic appendectomy. The histopathological examination revealed moderately differentiated appendiceal adenocarcinoma with mucinous areas, without lymphovascular or perineural invasion. The IHC examination was positive for keratin-20 and caudal type homeobox 2, and negative for MutL Homolog 1, MutS Homolog (MSH) 2 and MSH-6. A postoperative colonoscopy revealed diverticulosis, without the presence of polyps or tumors. However, an abdominal axial computerized tomography scan revealed thickening of the distal portion of the appendix, increased density of the greater omentum, and metastases to the liver capsule, spleen and peritoneum. The treatment of choice was right hemicolectomy with peritoneal debulking, followed by 10 cycles of chemotherapy with 5-fluorouracil, leucovorin and oxaliplatin (FOLFOX regimen). After 5 years of follow-up, the patient remains in good condition, without clinical or radiological signs of recurrence. The good response to chemotherapy corresponds with the observations made in other colon cancers with MSI. Therefore, testing for MSI in appendiceal carcinomas may provide useful information on prognosis and predict response to chemotherapy. |
| References: | Br J Cancer. 2011 Mar 15;104(6):1000-6. (PMID: 21364588) Hematol Oncol Clin North Am. 2015 Feb;29(1):29-41. (PMID: 25475571) Int J Colorectal Dis. 2007 Oct;22(10):1239-48. (PMID: 17447078) Scand J Gastroenterol. 2012 Mar;47(3):277-85. (PMID: 22263634) Dis Colon Rectum. 2015 Mar;58(3):288-93. (PMID: 25664706) Cancer. 2016 Jan 15;122(2):213-21. (PMID: 26506400) J Res Med Sci. 2015 Jan;20(1):103-4. (PMID: 25767531) Am J Surg Pathol. 2013 Aug;37(8):1192-200. (PMID: 23648460) Ann Surg Oncol. 2012 May;19(5):1379-85. (PMID: 22302267) Int J Cancer. 2003 Aug 10;106(1):66-73. (PMID: 12794758) Biochimie. 2002 Jan;84(1):27-47. (PMID: 11900875) Am Surg. 2004 Jul;70(7):593-9. (PMID: 15279181) Ann Surg. 1976 Jan;183(1):53-7. (PMID: 1247301) Semin Diagn Pathol. 2004 May;21(2):120-33. (PMID: 15807472) Ann Surg Oncol. 2015 Oct;22(11):3613-7. (PMID: 25663593) J Surg Oncol. 1997 Sep;66(1):51-3. (PMID: 9290693) Dig Surg. 2005;22(3):163-7. (PMID: 16037676) N Engl J Med. 2003 Jul 17;349(3):247-57. (PMID: 12867608) Cancer Epidemiol Biomarkers Prev. 2001 Sep;10(9):917-23. (PMID: 11535541) Sci Rep. 2016 Dec 16;6:39027. (PMID: 27982068) Dis Colon Rectum. 1988 Feb;31(2):145-50. (PMID: 3276467) Ann Surg Oncol. 2014 Jun;21(6):1975-82. (PMID: 24398544) Gastroenterology. 2004 Feb;126(2):394-401. (PMID: 14762775) BMC Cancer. 2014 Nov 04;14 :807. (PMID: 25369730) J Med Genet. 2000 Sep;37(9):641-5. (PMID: 10978352) Mod Pathol. 2007 Dec;20(12 ):1286-97. (PMID: 17906616) Clin Colon Rectal Surg. 2015 Dec;28(4):247-55. (PMID: 26648795) Cancer J. 2009 May-Jun;15(3):225-35. (PMID: 19556909) J Cancer Res Clin Oncol. 2013 Nov;139(11):1899-1908. (PMID: 24052322) Endocr Pathol. 2007 Spring;18(1):16-22. (PMID: 17652796) Eur J Surg. 1998 Nov;164(11):859-62. (PMID: 9845132) Cancer. 2001 Jun 15;91(12):2417-22. (PMID: 11413533) |
| فهرسة مساهمة: | Keywords: appendiceal adenocarcinoma; microsatellite instability; peritoneal metastases; prognosis |
| تواريخ الأحداث: | Date Created: 20180505 Latest Revision: 20200930 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC5920207 |
| DOI: | 10.3892/mco.2018.1596 |
| PMID: | 29725538 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2049-9450 |
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| DOI: | 10.3892/mco.2018.1596 |