Right Ventricular Dysfunction and Long-Term Risk of Sudden Cardiac Death in Patients With and Without Severe Left Ventricular Dysfunction.

التفاصيل البيبلوغرافية
العنوان:	Right Ventricular Dysfunction and Long-Term Risk of Sudden Cardiac Death in Patients With and Without Severe Left Ventricular Dysfunction.
المؤلفون:	Naksuk N; Departments of Cardiovascular Medicine (N.N., D.P., K.K., N.M., P.K., D.C.R., A.M.S., A.N.R., S.J.A., S.K., C.J.M.)., Tan N; and Internal Medicine (N.T., M.A.E.-H.)., Padmanabhan D; Departments of Cardiovascular Medicine (N.N., D.P., K.K., N.M., P.K., D.C.R., A.M.S., A.N.R., S.J.A., S.K., C.J.M.)., Kancharla K; Departments of Cardiovascular Medicine (N.N., D.P., K.K., N.M., P.K., D.C.R., A.M.S., A.N.R., S.J.A., S.K., C.J.M.).; Mayo Clinic, Rochester, MN. Department of Cardiovascular Medicine, University of Pittsburgh Medical Center, PA (K.K.)., Makkar N; Departments of Cardiovascular Medicine (N.N., D.P., K.K., N.M., P.K., D.C.R., A.M.S., A.N.R., S.J.A., S.K., C.J.M.)., Yogeswaran V; Mayo Clinic School of Medicine (V.Y., P.G.)., Gaba P; Mayo Clinic School of Medicine (V.Y., P.G.)., Kaginele P; Departments of Cardiovascular Medicine (N.N., D.P., K.K., N.M., P.K., D.C.R., A.M.S., A.N.R., S.J.A., S.K., C.J.M.)., Riley DC; Departments of Cardiovascular Medicine (N.N., D.P., K.K., N.M., P.K., D.C.R., A.M.S., A.N.R., S.J.A., S.K., C.J.M.)., Sugrue AM; Departments of Cardiovascular Medicine (N.N., D.P., K.K., N.M., P.K., D.C.R., A.M.S., A.N.R., S.J.A., S.K., C.J.M.)., Rosenbaum AN; Departments of Cardiovascular Medicine (N.N., D.P., K.K., N.M., P.K., D.C.R., A.M.S., A.N.R., S.J.A., S.K., C.J.M.)., El-Harasis MA; and Internal Medicine (N.T., M.A.E.-H.)., Asirvatham SJ; Departments of Cardiovascular Medicine (N.N., D.P., K.K., N.M., P.K., D.C.R., A.M.S., A.N.R., S.J.A., S.K., C.J.M.).; and Department of Pediatrics and Adolescent Medicine (S.J.A.)., Kapa S; Departments of Cardiovascular Medicine (N.N., D.P., K.K., N.M., P.K., D.C.R., A.M.S., A.N.R., S.J.A., S.K., C.J.M.)., McLeod CJ; Departments of Cardiovascular Medicine (N.N., D.P., K.K., N.M., P.K., D.C.R., A.M.S., A.N.R., S.J.A., S.K., C.J.M.) mcleod.christopher@mayo.edu.; Mayo Clinic College of Medicine and Science, Rochester, MN. Mayo Clinic School of Medicine, Mayo Clinic College of Medicine and Science, Jacksonville, FL (C.J.M.).
المصدر:	Circulation. Arrhythmia and electrophysiology [Circ Arrhythm Electrophysiol] 2018 Jun; Vol. 11 (6), pp. e006091.
نوع المنشور:	Comparative Study; Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 101474365 Publication Model: Print Cited Medium: Internet ISSN: 1941-3084 (Electronic) Linking ISSN: 19413084 NLM ISO Abbreviation: Circ Arrhythm Electrophysiol
أسماء مطبوعة:	Original Publication: Hagerstown, MD : Lippincott Williams & Wilkins
مواضيع طبية MeSH:	Ventricular Function, Left* , Ventricular Function, Right, Death, Sudden, Cardiac/epidemiology , Ventricular Dysfunction, Left/mortality , Ventricular Dysfunction, Right/mortality, Aged ; Aged, 80 and over ; Cause of Death ; Databases, Factual ; Electronic Health Records ; Female ; Humans ; Male ; Middle Aged ; Minnesota/epidemiology ; Prevalence ; Prognosis ; Risk Assessment ; Risk Factors ; Severity of Illness Index ; Stroke Volume ; Time Factors ; Ventricular Dysfunction, Left/diagnosis ; Ventricular Dysfunction, Left/physiopathology ; Ventricular Dysfunction, Right/diagnosis ; Ventricular Dysfunction, Right/physiopathology
مستخلص:	Background: Right ventricular systolic dysfunction (RVD) often coexists with various cardiopulmonary diseases. However, the association between RVD and risk of sudden cardiac death (SCD) has not been well studied. This study examined the risk of SCD associated with RVD in patients with heterogeneous underlying cardiac diseases. Methods: The Mayo Clinic cardiac care unit database included 5463 consecutive patients with complete echocardiographic evaluation to assess right ventricular systolic function and RVD severity. Prospective surveillance follow-up was obtained for all patients. SCD was adjudicated when a malignant ventricular arrhythmia was documented as the primary rhythm leading to death. Results: The prevalence of mild RVD and moderate-severe RVD was 14.9% and 17.1%, respectively. Patients with RVD were more likely to have a history of congestive heart failure, cardiac arrest, pulmonary disease, and lower baseline left ventricular ejection fraction compared with those with normal right ventricular systolic function. During a median follow-up of 14 months, the incidence of SCD was highest in patients with moderate-severe RVD (7.4% versus 4.4% in mild RVD versus 1.6% in normal right ventricular function; P <0.001). After adjustment for baseline characteristics, mild RVD (adjusted hazard ratio, 1.57; P =0.046) and moderate-severe RVD (adjusted hazard ratio, 1.91; P =0.006) were independently associated with an increased risk of SCD. Moderate-severe RVD remained an independent predictor of SCD for patients with left ventricular ejection fraction >35% without or with preexisting implantable cardioverter-defibrillator (adjusted hazard ratio, 4.12; P =0.003 and adjusted hazard ratio, 5.04; P <0.001, respectively). Conclusions: Presence of RVD in patients with a history of preexisting cardiac disease is an independent predictor of SCD irrespective of left ventricular ejection fraction. (© 2018 American Heart Association, Inc.)
التعليقات:	Erratum in: Circ Arrhythm Electrophysiol. 2018 Aug;11(8):e000031. (PMID: 30354320)
فهرسة مساهمة:	Keywords: echocardiography; follow-up studies; heart failure; implantable defibrillators; right ventricular systolic function; sudden cardiac death
تواريخ الأحداث:	Date Created: 20180518 Date Completed: 20190813 Latest Revision: 20190813
رمز التحديث:	20240829
DOI:	10.1161/CIRCEP.117.006091
PMID:	29769224
قاعدة البيانات:	MEDLINE

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الوصف
تدمد:	1941-3084
DOI:	10.1161/CIRCEP.117.006091