دورية أكاديمية
[The preliminary analysis of chronic rhinosinusitis: clinical phenotypes and inflammation features].
| العنوان: | [The preliminary analysis of chronic rhinosinusitis: clinical phenotypes and inflammation features]. |
|---|---|
| المؤلفون: | Bai Y; Department of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Beijing, 100853, China., Ao YY; Department of Pathology, Chinese PLA General Hospital., Xu C; Department of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Beijing, 100853, China., Qiu X; Department of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Beijing, 100853, China., Zhang Y; Department of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Beijing, 100853, China., Wang HT; Department of Otolaryngology Head and Neck Surgery, Hainan Branch of Chinese PLA General Hospital. |
| المصدر: | Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery [Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi] 2017 Jan 20; Vol. 31 (2), pp. 107-110. |
| نوع المنشور: | Journal Article |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Lin chuang er bi yan hou tou jing wai ke za zhi bain ji bu Country of Publication: China NLM ID: 101303164 Publication Model: Print Cited Medium: Print ISSN: 2096-7993 (Print) Linking ISSN: 20967993 NLM ISO Abbreviation: Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Wuhan Shi : Lin chuang er bi yan hou tou jing wai ke za zhi bain ji bu |
| مواضيع طبية MeSH: | Inflammation/*immunology , Nasal Polyps/*diagnosis , Rhinitis/*diagnosis , Sinusitis/*diagnosis, Chronic Disease ; Humans ; Nasal Polyps/complications ; Phenotype ; Rhinitis/complications ; Sinusitis/complications |
| مستخلص: | Objective: To explore the clinical phenotypes and inflammatory features of chronic rhinosinusitis in the liminary study. Method: Twenty-five patients suffered with chronic rhinosinusitis and nasal polyps (CRSwNP) and 23 patients suffered with chronic rhinosinusitis without nasal polyps (CRSsNP) were enrolled in our study. Analysis was made in clinical features of the two types, including symptoms with VAS score, nasal endoscopy with Lanza-Kennedy score,and nasal sinus CT with Lund-Mackay score. Eosinophil and neutrophil distribution of lesions in the two groups were compared, inflammatory markers expression of interleukin (IL-5), interleukin-17(IL-17) and interferon gamma (IFN-γ) were assessed. Result: The VAS score of nasal obstruction, nasal endoscopic score and CT score were significantly higher in patients with CRSwNP than that in patients with CRSsNP ( P < 0.05). HE staining showed that the lesions in patients with type two were infiltrated by mixed inflammatory cells. 41% (10 cases) out of patients with CRSwNP were mainly with eosinophils infiltration and 59% (15 cases) with neutrophil infiltration. 78%(18 cases) out of patients with CRSsNP were with eosinophilic infiltration and 22% (5 cases) with neutrophil infiltration. The expression of inflammatory factors IL-5, IL-17 and IFN in patients with CRSwNP was significantly increased compared with that in patients with CRSsNP ( P < 0.05). Conclusion: The clinical manifestation and the degree of inflammation of patients with CRSwNP are more severe than that of patients with CRSsNP. Lesions in both groups are infiltrated by mixed inflammatory cells. Competing Interests: The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose. (Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.) |
| فهرسة مساهمة: | Keywords: chronic rhinosinusitis; eosinophils; inflammatory cytokines; nasal polyps |
| تواريخ الأحداث: | Date Created: 20180606 Date Completed: 20180829 Latest Revision: 20181202 |
| رمز التحديث: | 20231215 |
| DOI: | 10.13201/j.issn.1001-1781.2017.02.007 |
| PMID: | 29871198 |
| قاعدة البيانات: | MEDLINE |
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