دورية أكاديمية
Genetic variation in the Hippo pathway and breast cancer risk in women of African ancestry.
| العنوان: | Genetic variation in the Hippo pathway and breast cancer risk in women of African ancestry. |
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| المؤلفون: | Wang S; Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China.; Center for Clinical Cancer Genetics and Global Health, Department of Medicine, University of Chicago, Chicago, Illinois., Huo D; Department of Public Health Sciences, University of Chicago, Chicago, Illinois., Ogundiran TO; Department of Surgery, College of Medicine, University of Ibadan, Ibadan, Nigeria., Ojengbede O; Center for Population and Reproductive Health, College of Medicine, University of Ibadan, Ibadan, Nigeria., Zheng W; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee., Nathanson KL; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Nemesure B; Department of Preventive Medicine, State University of New York at Stony Brook, Stony Brook, New York., Ambs S; Laboratory of Human Carcinogenesis, National Cancer Institute, Bethesda, Maryland., Olopade OI; Center for Clinical Cancer Genetics and Global Health, Department of Medicine, University of Chicago, Chicago, Illinois., Zheng Y; Center for Clinical Cancer Genetics and Global Health, Department of Medicine, University of Chicago, Chicago, Illinois. |
| المصدر: | Molecular carcinogenesis [Mol Carcinog] 2018 Oct; Vol. 57 (10), pp. 1311-1318. Date of Electronic Publication: 2018 Jun 14. |
| نوع المنشور: | Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8811105 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-2744 (Electronic) Linking ISSN: 08991987 NLM ISO Abbreviation: Mol Carcinog Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2005- > : [Hoboken, N.J.] : Wiley-Liss Original Publication: New York : Alan R. Liss, Inc., c1988- |
| مواضيع طبية MeSH: | Polymorphism, Single Nucleotide*, Black People/*genetics , Breast Neoplasms/*genetics , Genetic Predisposition to Disease/*genetics , Protein Serine-Threonine Kinases/*genetics , Signal Transduction/*genetics, Barbados ; Breast Neoplasms/ethnology ; Breast Neoplasms/metabolism ; Case-Control Studies ; Female ; Genetic Association Studies ; Genetic Predisposition to Disease/ethnology ; Genome-Wide Association Study ; Genotype ; Hippo Signaling Pathway ; Humans ; Middle Aged ; Nigeria ; Receptors, Estrogen/metabolism ; United States ; Black or African American |
| مستخلص: | Gene expression changes within the Hippo pathway were found to be associated with large tumor size and metastasis in breast cancer. The combined effect of genetic variants in genes of this pathway may have a causal role in breast cancer development. We examined 7086 SNPs that were not highly correlated (r 2 < 0.8) in 35 Hippo pathway genes using data from the genome-wide association study of breast cancer from the Root Consortium, which includes 3686 participants of African ancestry from Nigeria, United States of America, and Barbados: 1657 cases (403 estrogen receptor-positive [ER+], 374 ER-) and 2029 controls. Gene-level analyses were conducted using improved AdaJoint test for large-scale genetic association studies adjusting for age, study site and the first four eigenvectors from the principal component analysis. SNP-level analyses were conducted with logistic regression. The Hippo pathway was significantly associated with risk of ER+ breast cancer (pathway-level P = 0.019), with WWC1 (P (© 2018 Wiley Periodicals, Inc.) |
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| معلومات مُعتمدة: | K12 CA139160 United States CA NCI NIH HHS; R01 CA142996 United States CA NCI NIH HHS; U01 CA161032 United States CA NCI NIH HHS |
| فهرسة مساهمة: | Keywords: Hippo pathway; SNPs; adaptive joint multilocus test; breast cancer; women of African ancestry |
| المشرفين على المادة: | 0 (Receptors, Estrogen) EC 2.7.11.1 (Protein Serine-Threonine Kinases) |
| تواريخ الأحداث: | Date Created: 20180607 Date Completed: 20190503 Latest Revision: 20240712 |
| رمز التحديث: | 20240712 |
| مُعرف محوري في PubMed: | PMC6662580 |
| DOI: | 10.1002/mc.22845 |
| PMID: | 29873413 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1098-2744 |
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| DOI: | 10.1002/mc.22845 |