دورية أكاديمية
IL-36 and IL-1/IL-17 Drive Immunity to Oral Candidiasis via Parallel Mechanisms.
| العنوان: | IL-36 and IL-1/IL-17 Drive Immunity to Oral Candidiasis via Parallel Mechanisms. |
|---|---|
| المؤلفون: | Verma AH; Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA 15261., Zafar H; Mucosal and Salivary Biology Division, King's College London Dental Institute, London SE1 1UL, United Kingdom.; Centre for Host-Microbiome Interactions, Mucosal and Salivary Biology Division, King's College London Dental Institute, London SE1 9RT, United Kingdom., Ponde NO; Mucosal and Salivary Biology Division, King's College London Dental Institute, London SE1 1UL, United Kingdom., Hepworth OW; Mucosal and Salivary Biology Division, King's College London Dental Institute, London SE1 1UL, United Kingdom.; Centre for Host-Microbiome Interactions, Mucosal and Salivary Biology Division, King's College London Dental Institute, London SE1 9RT, United Kingdom., Sihra D; Mucosal and Salivary Biology Division, King's College London Dental Institute, London SE1 1UL, United Kingdom., Aggor FEY; Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA 15261., Ainscough JS; Faculty of Biological Sciences, School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom., Ho J; Mucosal and Salivary Biology Division, King's College London Dental Institute, London SE1 1UL, United Kingdom., Richardson JP; Mucosal and Salivary Biology Division, King's College London Dental Institute, London SE1 1UL, United Kingdom., Coleman BM; Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA 15261., Hube B; Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knoell Institute, D-07745 Jena, Germany.; Friedrich Schiller University, D-07737 Jena, Germany; and.; Center for Sepsis Control and Care, D-07747 Jena, Germany., Stacey M; Faculty of Biological Sciences, School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom., McGeachy MJ; Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA 15261., Naglik JR; Mucosal and Salivary Biology Division, King's College London Dental Institute, London SE1 1UL, United Kingdom., Gaffen SL; Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA 15261; david.moyes@kcl.ac.uk sarah.gaffen@pitt.edu., Moyes DL; Mucosal and Salivary Biology Division, King's College London Dental Institute, London SE1 1UL, United Kingdom; david.moyes@kcl.ac.uk sarah.gaffen@pitt.edu.; Centre for Host-Microbiome Interactions, Mucosal and Salivary Biology Division, King's College London Dental Institute, London SE1 9RT, United Kingdom. |
| المصدر: | Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2018 Jul 15; Vol. 201 (2), pp. 627-634. Date of Electronic Publication: 2018 Jun 11. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association of Immunologists Country of Publication: United States NLM ID: 2985117R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1550-6606 (Electronic) Linking ISSN: 00221767 NLM ISO Abbreviation: J Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Bethesda, MD : American Association of Immunologists Original Publication: Baltimore : Williams & Wilkins, c1950- |
| مواضيع طبية MeSH: | Candida albicans/*immunology , Candidiasis/*immunology , Fungal Proteins/*metabolism , Interleukin-1/*metabolism , Interleukin-17/*metabolism , Mouth Mucosa/*physiology, Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Cell Line ; Gene Expression Regulation ; Immunity, Innate ; Interleukin-23/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mouth Mucosa/microbiology ; Receptors, Interleukin-1/genetics ; Signal Transduction ; p38 Mitogen-Activated Protein Kinases/metabolism |
| مستخلص: | Protection against microbial infection by the induction of inflammation is a key function of the IL-1 superfamily, including both classical IL-1 and the new IL-36 cytokine families. Candida albicans is a frequent human fungal pathogen causing mucosal infections. Although the initiators and effectors important in protective host responses to C. albicans are well described, the key players in driving these responses remain poorly defined. Recent work has identified a central role played by IL-1 in inducing innate Type-17 immune responses to clear C. albicans infections. Despite this, lack of IL-1 signaling does not result in complete loss of immunity, indicating that there are other factors involved in mediating protection to this fungus. In this study, we identify IL-36 cytokines as a new player in these responses. We show that C. albicans infection of the oral mucosa induces the production of IL-36. As with IL-1α/β, induction of epithelial IL-36 depends on the hypha-associated peptide toxin Candidalysin. Epithelial IL-36 gene expression requires p38-MAPK/c-Fos, NF-κB, and PI3K signaling and is regulated by the MAPK phosphatase MKP1. Oral candidiasis in IL-36R -/- mice shows increased fungal burdens and reduced IL-23 gene expression, indicating a key role played by IL-36 and IL-23 in innate protective responses to this fungus. Strikingly, we observed no impact on gene expression of IL-17 or IL-17-dependent genes, indicating that this protection occurs via an alternative pathway to IL-1-driven immunity. Thus, IL-1 and IL-36 represent parallel epithelial cell-driven protective pathways in immunity to oral C. albicans infection. (Copyright © 2018 by The American Association of Immunologists, Inc.) |
| References: | J Exp Med. 2009 Feb 16;206(2):299-311. (PMID: 19204111) Sci Transl Med. 2012 Dec 19;4(165):165rv13. (PMID: 23253612) Curr Infect Dis Rep. 2011 Feb;13(1):102-7. (PMID: 21308461) J Immunol. 2014 Jun 15;192(12):6053-61. (PMID: 24829417) Mucosal Immunol. 2013 Sep;6(5):900-10. (PMID: 23250275) Cell Microbiol. 2007 Dec;9(12):2938-54. (PMID: 17645752) Nitric Oxide. 2009 May;20(3):143-9. (PMID: 19135542) J Immunol. 2011 Feb 15;186(4):2613-22. (PMID: 21242515) J Bacteriol. 1999 Mar;181(6):1868-74. (PMID: 10074081) Sci Immunol. 2017 Nov 3;2(17):. (PMID: 29101209) United European Gastroenterol J. 2017 Aug;5(5):625-631. (PMID: 28815025) J Immunol. 2012 Jun 1;188(11):5636-43. (PMID: 22529294) Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):E2748-E2757. (PMID: 28289191) Front Immunol. 2018 Feb 26;9:200. (PMID: 29535706) Front Microbiol. 2016 Jun 17;7:955. (PMID: 27379082) Antimicrob Agents Chemother. 2001 Nov;45(11):3195-7. (PMID: 11600377) J Exp Med. 2007 Oct 29;204(11):2603-14. (PMID: 17908936) Cell Host Microbe. 2017 Nov 8;22(5):653-666.e5. (PMID: 29120743) PLoS One. 2015 Nov 12;10(11):e0138423. (PMID: 26562662) PLoS One. 2011;6(11):e26580. (PMID: 22087232) Mol Biol Cell. 2006 Jan;17(1):295-307. (PMID: 16267276) Cell Host Microbe. 2010 Sep 16;8(3):225-35. (PMID: 20833374) PLoS One. 2014 Jul 24;9(7):e103440. (PMID: 25058399) Infect Immun. 2014 Mar;82(3):1030-5. (PMID: 24343647) Med Microbiol Immunol. 2012 Feb;201(1):93-101. (PMID: 21706283) J Infect Dis. 2014 Jun 1;209(11):1816-26. (PMID: 24357630) J Immunol. 2014 Nov 15;193(10):5140-8. (PMID: 25305315) Immunity. 2015 Oct 20;43(4):727-38. (PMID: 26431948) J Immunol. 2016 Mar 1;196(5):2230-8. (PMID: 26819203) Cell Host Microbe. 2016 Nov 9;20(5):606-617. (PMID: 27923704) Trends Immunol. 2018 Apr;39(4):276-287. (PMID: 28923364) Cell. 1997 Sep 5;90(5):939-49. (PMID: 9298905) J Infect Dis. 2016 Aug 1;214(3):464-74. (PMID: 27389350) Sci Signal. 2017 Aug 15;10(492):. (PMID: 28811383) Immunity. 2015 Oct 20;43(4):739-50. (PMID: 26431947) Am J Physiol Cell Physiol. 2008 Jan;294(1):C241-50. (PMID: 18003751) mBio. 2018 Jan 23;9(1):. (PMID: 29362237) PLoS Pathog. 2016 Sep 15;12(9):e1005882. (PMID: 27632536) Mol Gen Genet. 1984;198(2):179-82. (PMID: 6394964) Mucosal Immunol. 2017 Jul;10(4):1043-1055. (PMID: 27966554) Virulence. 2015;6(4):338-46. (PMID: 25714110) Semin Immunol. 2013 Dec 15;25(6):458-65. (PMID: 24355486) Eur J Immunol. 2013 Feb;43(2):416-26. (PMID: 23147407) Gut. 2012 Dec;61(12):1693-700. (PMID: 22595313) Curr Opin Microbiol. 2017 Dec;40:46-57. (PMID: 29128761) Am J Respir Cell Mol Biol. 2011 Jul;45(1):145-53. (PMID: 20870894) Cell Host Microbe. 2017 Nov 8;22(5):667-677.e5. (PMID: 29120744) Nat Protoc. 2012 Mar 08;7(4):637-42. (PMID: 22402633) Nucleic Acids Res. 2010 Jan;38(Database issue):D792-9. (PMID: 19906719) Nature. 2016 Apr 7;532(7597):64-8. (PMID: 27027296) |
| معلومات مُعتمدة: | R01 DE022550 United States DE NIDCR NIH HHS; R37 DE022550 United States DE NIDCR NIH HHS; MR/J008303/1 United Kingdom MRC_ Medical Research Council; United Kingdom DH_ Department of Health; R01 DE023815 United States DE NIDCR NIH HHS; BB/N014677/1 United Kingdom BB_ Biotechnology and Biological Sciences Research Council; MR/M011372/1 United Kingdom MRC_ Medical Research Council |
| المشرفين على المادة: | 0 (Adaptor Proteins, Signal Transducing) 0 (ECE1 protein, Candida albicans) 0 (Fungal Proteins) 0 (Interleukin-1) 0 (Interleukin-17) 0 (Interleukin-23) 0 (Receptors, Interleukin-1) 0 (Traf3ip2 protein, mouse) 0 (interleukin-36 receptor, mouse) 0 (interleukin-36, mouse) EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases) |
| تواريخ الأحداث: | Date Created: 20180613 Date Completed: 20190705 Latest Revision: 20230926 |
| رمز التحديث: | 20240829 |
| مُعرف محوري في PubMed: | PMC6039262 |
| DOI: | 10.4049/jimmunol.1800515 |
| PMID: | 29891557 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1550-6606 |
|---|---|
| DOI: | 10.4049/jimmunol.1800515 |