دورية أكاديمية
The Effects of Long-Acting Stimulant and Nonstimulant Medications in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder: A Meta-Analysis of Randomized Controlled Trials.
| العنوان: | The Effects of Long-Acting Stimulant and Nonstimulant Medications in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder: A Meta-Analysis of Randomized Controlled Trials. |
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| المؤلفون: | Cerrillo-Urbina AJ; 1 Social and Health Care Research Center , Universidad de Castilla-La Mancha, Cuenca, Spain ., García-Hermoso A; 2 Laboratorio de Ciencias de la Actividad Física, el Deporte y la Salud, Facultad de Ciencias Médicas, Universidad de Santiago de Chile , USACH, Santiago, Chile ., Pardo-Guijarro MJ; 1 Social and Health Care Research Center , Universidad de Castilla-La Mancha, Cuenca, Spain .; 3 Faculty of Education, Universidad de Castilla-La Mancha , Cuenca, Spain ., Sánchez-López M; 1 Social and Health Care Research Center , Universidad de Castilla-La Mancha, Cuenca, Spain .; 4 Faculty of Education, Universidad de Castilla-La Mancha , Ciudad Real, Spain ., Santos-Gómez JL; 5 Department of Psychiatry, Hospital Virgen de la Luz , Cuenca, Spain ., Martínez-Vizcaíno V; 1 Social and Health Care Research Center , Universidad de Castilla-La Mancha, Cuenca, Spain .; 6 Facultad de Ciencias de la Salud, Universidad Autónoma de Chile , Talca, Chile . |
| المصدر: | Journal of child and adolescent psychopharmacology [J Child Adolesc Psychopharmacol] 2018 Oct; Vol. 28 (8), pp. 494-507. Date of Electronic Publication: 2018 Jun 13. |
| نوع المنشور: | Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Mary Ann Liebert Country of Publication: United States NLM ID: 9105358 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-8992 (Electronic) Linking ISSN: 10445463 NLM ISO Abbreviation: J Child Adolesc Psychopharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York : Mary Ann Liebert, c1990- |
| مواضيع طبية MeSH: | Randomized Controlled Trials as Topic*, Attention Deficit Disorder with Hyperactivity/*drug therapy , Central Nervous System Stimulants/*therapeutic use , Methylphenidate/*therapeutic use, Adolescent ; Child ; Humans ; Impulsive Behavior ; Medication Adherence |
| مستخلص: | Objective: The aim of this study was to assess the efficacy and safety of stimulant and nonstimulant medications in children and adolescents using as an outcome measure the Attention-Deficit/Hyperactivity Disorder Rating Scale-IV (ADHD-RS-IV), and to examine the effect of medications in different ADHD subtypes (i.e., inattention and hyperactivity/impulsivity). Methods: MEDLINE, Scopus, EMBASE, EBSCO (E-journal, CINAHL and SportDiscus), PUBMED, and The Cochrane Central Register of Controlled Trials databases were searched. Randomized controlled trials (RCTs) with parallel group or placebo-controlled studies comparing the effect of medications (stimulants or nonstimulants) in children and adolescents with ADHD were included. The main outcomes were the ADHD-RS-IV total score and subtypes (inattention and hyperactivity/impulsivity). Treatment-emergent adverse events (TEAEs) and secondary outcomes such as systolic and diastolic blood pressure, and pulse rate were considered. Results: The search strategy identified 15 RCTs, including a total of 4648 children and/or adolescents diagnosed with ADHD aged 6 to 17 years old. Overall, both stimulant and nonstimulant medications reduce the ADHD-RS-IV score with a standardized mean difference (SMD) of -0.70 (confidence interval [95% CI], -0.85 to -0.55); in subgroup analyses, the SMD was -0.83 (95% CI, -1.11 to -0.54) for stimulant medications and -0.58 (95% CI, -0.69 to -0.46) for nonstimulant medications. Similar results were observed in inattention and hyperactivity/impulsivity subtypes. The placebo group also showed a medium effect SMD of -0.68 (95% CI, -0.82 to -0.54). The most frequent TEAEs for stimulant and nonstimulant medications, respectively, were decreased appetite (28.6% and 14.2%) and somnolence (4.4% and 34.1%). Conclusions: These results suggest that both stimulant and nonstimulant medications mitigate ADHD symptoms in children and adolescents, although subgroup analyses suggest a greater effectiveness of stimulant medications. |
| فهرسة مساهمة: | Keywords: ADHD; hyperactivity/impulsivity; inattention; pharmacological intervention; youths |
| المشرفين على المادة: | 0 (Central Nervous System Stimulants) 207ZZ9QZ49 (Methylphenidate) |
| تواريخ الأحداث: | Date Created: 20180614 Date Completed: 20191004 Latest Revision: 20191007 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1089/cap.2017.0151 |
| PMID: | 29897263 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1557-8992 |
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| DOI: | 10.1089/cap.2017.0151 |