دورية أكاديمية
Protection from UV light is an evolutionarily conserved feature of the haematopoietic niche.
| العنوان: | Protection from UV light is an evolutionarily conserved feature of the haematopoietic niche. |
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| المؤلفون: | Kapp FG; Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA.; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA, USA.; Department of Pediatric Hematology and Oncology, Center for Pediatrics, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Perlin JR; Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA.; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA, USA., Hagedorn EJ; Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA.; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA, USA., Gansner JM; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Schwarz DE; US Fish and Wildlife Service, Private John Allen National Fish Hatchery, Tupelo, MS, USA., O'Connell LA; Department of Biology, Stanford University, Stanford, CA, USA., Johnson NS; US Geological Survey, Great Lakes Science Center, Hammond Bay Biological Station, Millersburg, MI, USA., Amemiya C; Molecular Cell Biology, University of California, Merced, CA, USA., Fisher DE; Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA., Wölfle U; Department of Dermatology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Trompouki E; Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany., Niemeyer CM; Department of Pediatric Hematology and Oncology, Center for Pediatrics, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Driever W; Developmental Biology, Faculty of Biology, Centre for Biological Signalling Studies (BIOSS), Albert-Ludwigs-University of Freiburg, Freiburg, Germany., Zon LI; Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA. zon@enders.tch.harvard.edu.; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA, USA. zon@enders.tch.harvard.edu. |
| المصدر: | Nature [Nature] 2018 Jun; Vol. 558 (7710), pp. 445-448. Date of Electronic Publication: 2018 Jun 13. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Basingstoke : Nature Publishing Group Original Publication: London, Macmillan Journals ltd. |
| مواضيع طبية MeSH: | Biological Evolution*, Hematopoietic Stem Cells/*cytology , Hematopoietic Stem Cells/*radiation effects , Melanocytes/*cytology , Melanocytes/*radiation effects , Stem Cell Niche/*radiation effects , Ultraviolet Rays/*adverse effects, Animals ; Aquatic Organisms/classification ; Cytoprotection/radiation effects ; DNA Damage/radiation effects ; Kidney ; Mutation ; Petromyzon/classification ; Phylogeny ; Pyrimidine Dimers/radiation effects ; Stem Cell Niche/physiology ; Zebrafish/classification ; Zebrafish/genetics |
| مستخلص: | Haematopoietic stem and progenitor cells (HSPCs) require a specific microenvironment, the haematopoietic niche, which regulates HSPC behaviour 1,2 . The location of this niche varies across species, but the evolutionary pressures that drive HSPCs to different microenvironments remain unknown. The niche is located in the bone marrow in adult mammals, whereas it is found in other locations in non-mammalian vertebrates, for example, in the kidney marrow in teleost fish. Here we show that a melanocyte umbrella above the kidney marrow protects HSPCs against ultraviolet light in zebrafish. Because mutants that lack melanocytes have normal steady-state haematopoiesis under standard laboratory conditions, we hypothesized that melanocytes above the stem cell niche protect HSPCs against ultraviolet-light-induced DNA damage. Indeed, after ultraviolet-light irradiation, unpigmented larvae show higher levels of DNA damage in HSPCs, as indicated by staining of cyclobutane pyrimidine dimers and have reduced numbers of HSPCs, as shown by cmyb (also known as myb) expression. The umbrella of melanocytes associated with the haematopoietic niche is highly evolutionarily conserved in aquatic animals, including the sea lamprey, a basal vertebrate. During the transition from an aquatic to a terrestrial environment, HSPCs relocated into the bone marrow, which is protected from ultraviolet light by the cortical bone around the marrow. Our studies reveal that melanocytes above the haematopoietic niche protect HSPCs from ultraviolet-light-induced DNA damage in aquatic vertebrates and suggest that during the transition to terrestrial life, ultraviolet light was an evolutionary pressure affecting the location of the haematopoietic niche. |
| التعليقات: | Comment in: Nature. 2018 Jun;558(7710):374-375. doi: 10.1038/d41586-018-05166-1. (PMID: 29907823) Comment in: Lab Anim (NY). 2018 Aug;47(8):212. doi: 10.1038/s41684-018-0120-x. (PMID: 30042453) |
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| معلومات مُعتمدة: | T32 HL066987 United States HL NHLBI NIH HHS; U01 HL134812 United States HL NHLBI NIH HHS; R24 RR017441 United States RR NCRR NIH HHS; R01 DK053298 United States DK NIDDK NIH HHS; United States HHMI Howard Hughes Medical Institute; K01 DK111790 United States DK NIDDK NIH HHS; P01 CA163222 United States CA NCI NIH HHS; R01 CA103846 United States CA NCI NIH HHS; U01 HL100001 United States HL NHLBI NIH HHS; P01 HL032262 United States HL NHLBI NIH HHS; T32 HL116324 United States HL NHLBI NIH HHS; T32 CA009172 United States CA NCI NIH HHS; R01 HL048801 United States HL NHLBI NIH HHS; P01 HL131477 United States HL NHLBI NIH HHS; R01 AR043369 United States AR NIAMS NIH HHS; U54 DK110805 United States DK NIDDK NIH HHS; R24 DK092760 United States DK NIDDK NIH HHS |
| المشرفين على المادة: | 0 (Pyrimidine Dimers) |
| تواريخ الأحداث: | Date Created: 20180615 Date Completed: 20181211 Latest Revision: 20240610 |
| رمز التحديث: | 20240610 |
| مُعرف محوري في PubMed: | PMC6093292 |
| DOI: | 10.1038/s41586-018-0213-0 |
| PMID: | 29899448 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1476-4687 |
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| DOI: | 10.1038/s41586-018-0213-0 |