دورية أكاديمية
[Study of Rhizoma Darynaria on regulation of cellular immune function in immunosuppressive mice].
| العنوان: | [Study of Rhizoma Darynaria on regulation of cellular immune function in immunosuppressive mice]. |
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| المؤلفون: | Zhao G; Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning 530003, China., He G; Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning 530003, China., Lu C; Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning 530003, China., Lao L; Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning 530003, China., Wei J; Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning 530003, China. |
| المصدر: | Wei sheng yan jiu = Journal of hygiene research [Wei Sheng Yan Jiu] 2017 Jan; Vol. 46 (1), pp. 84-93. |
| نوع المنشور: | Journal Article |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Wei sheng yan jiu bian ji bu Country of Publication: China NLM ID: 9426367 Publication Model: Print Cited Medium: Print ISSN: 1000-8020 (Print) Linking ISSN: 10008020 NLM ISO Abbreviation: Wei Sheng Yan Jiu Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Beijing Shi : Wei sheng yan jiu bian ji bu Original Publication: Beijing Shi : "Wei sheng yan jiu" bian ji bu, |
| مواضيع طبية MeSH: | Cyclophosphamide/*adverse effects , Immune System/*drug effects , Immunity, Cellular/*drug effects , Immunosuppression Therapy/*methods , Immunosuppressive Agents/*pharmacology , Plant Extracts/*pharmacology, Animals ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Interferon-gamma/blood ; Interleukin-4/blood ; Mice ; Mice, Inbred BALB C ; Plant Extracts/administration & dosage ; Plant Extracts/isolation & purification ; Plant Extracts/toxicity ; Spleen/drug effects ; Spleen/immunology |
| مستخلص: | Objective: To study the effect of Rhizoma Drynaria ethanol extract on regulation of cellular immune functions in cyclophosphamide-induced immunosuppressive mice. Methods: A total of 60 kunming mice were randomly divided into six groups:normal control group, model group, positive control group( levamisole, 0. 05 g / kg) and low-, medium- and high-dose Rhizoma Drynaria ethanol extract-treated groups( 2. 5, 5, 10 g / kg). The mice in the four administration group were administered with 10 mL / kg of the drug for 20 days. Except normal control group, the mice in the other 5 groups were intraperitoneally injected( ip) with cyclophosphamide to establish immunosuppression model. After the end of the experiment, the indices of lymphocyte proliferation capacity and delayed type hypersensitivity were detected, speen histological structure and Tlymphocyte subsets CD_4~+, CD_8~+T cells in peripheral blood were measured. The relativemRNA expression of Interleukin 4( IL-4) and Interferon-γ( IFN-γ) in the spleen tissues were detected. Results: Rhizoma Drynaria ethanol extract( 5, 10 g / kg) enhanced Con Ainduced T-lymphocytes proliferative capacity and delayed type hypersensitivity, increased CD_4~+T cells, CD_4~+/ CD_8~+ratio in peripheral blood, IFN-γ mRNA expression and IFN-γ /IL-4 ratio, decreased CD_8~+T cells and IL-4 mRNA expression. However, there was no obvious difference in LPS-induced B-lymphocyte proliferation capacity. Conclusion: Rhizoma Drynaria ethanol extract could regulate the cellular immune functions in cyclophosphamide-induced immunosuppressive mice. |
| فهرسة مساهمة: | Keywords: Rhizoma drynaria ethanol extract; cellular immune; immunosuppression; regulation |
| المشرفين على المادة: | 0 (IL4 protein, human) 0 (Immunosuppressive Agents) 0 (Plant Extracts) 207137-56-2 (Interleukin-4) 82115-62-6 (Interferon-gamma) 8N3DW7272P (Cyclophosphamide) |
| تواريخ الأحداث: | Date Created: 20180616 Date Completed: 20181010 Latest Revision: 20211204 |
| رمز التحديث: | 20221213 |
| PMID: | 29903157 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1000-8020 |
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