دورية أكاديمية
The "three-in-one" formulation of bismuth quadruple therapy for Helicobacter pylori eradication with or without probiotics supplementation: Efficacy and safety in daily clinical practice.
| العنوان: | The "three-in-one" formulation of bismuth quadruple therapy for Helicobacter pylori eradication with or without probiotics supplementation: Efficacy and safety in daily clinical practice. |
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| المؤلفون: | Zagari RM; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy., Romiti A; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy., Ierardi E; Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy., Gravina AG; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy., Panarese A; Department of Gastroenterology and Digestive Endoscopy, National Institute of Gastroenterology, IRCCS 'Saverio De Bellis', Castellana Grotte (Bari), Italy., Grande G; Gastroenterology and Digestive Endoscopy Unit, Ospedale Civile Sant' Agostino-Estense, Azienda Ospedaliero-Universitaria, Modena, Italy., Savarino E; Section of Gastroenterology - Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy., Maconi G; Gastroenterology Unit, Department of Biomedical and Clinical Sciences, University Hospital 'L. Sacco', Milan, Italy., Stasi E; Department of Gastroenterology and Digestive Endoscopy, National Institute of Gastroenterology, IRCCS 'Saverio De Bellis', Castellana Grotte (Bari), Italy., Eusebi LH; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy., Farinati F; Section of Gastroenterology - Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy., Conigliaro R; Gastroenterology and Digestive Endoscopy Unit, Ospedale Civile Sant' Agostino-Estense, Azienda Ospedaliero-Universitaria, Modena, Italy., Bazzoli F; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy., Romano M; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy. |
| المصدر: | Helicobacter [Helicobacter] 2018 Aug; Vol. 23 (4), pp. e12502. Date of Electronic Publication: 2018 Jun 20. |
| نوع المنشور: | Clinical Trial; Journal Article; Multicenter Study; Observational Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 9605411 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-5378 (Electronic) Linking ISSN: 10834389 NLM ISO Abbreviation: Helicobacter Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Wiley-Blackwell Original Publication: Malden, MA : Wiley-Blackwell, c1996- |
| مواضيع طبية MeSH: | Anti-Bacterial Agents/*administration & dosage , Bismuth/*administration & dosage , Helicobacter Infections/*drug therapy , Metronidazole/*administration & dosage , Probiotics/*administration & dosage , Tetracycline/*administration & dosage, Adult ; Aged ; Anti-Bacterial Agents/adverse effects ; Bismuth/adverse effects ; Drug Therapy, Combination/adverse effects ; Female ; Helicobacter Infections/microbiology ; Helicobacter pylori/drug effects ; Helicobacter pylori/physiology ; Humans ; Italy ; Male ; Metronidazole/adverse effects ; Middle Aged ; Probiotics/adverse effects ; Proton Pump Inhibitors/administration & dosage ; Proton Pump Inhibitors/adverse effects ; Retrospective Studies ; Tetracycline/adverse effects |
| مستخلص: | Background: Clinical trials have shown a good efficacy of the "three-in-one" formulation of bismuth quadruple therapy (BQT) for Helicobacter (H.) pylori eradication. We aimed to assess the efficacy and safety of the three-in-one BQT in clinical practice, and investigate the effect of probiotic supplementation, in Italy. Materials and Methods: A retrospective database, multicentre observational study was conducted in seven Italian Hospitals. Consecutive H. pylori-positive patients who received the three-in-one BQT for 10 days were included in the analysis. H. pylori eradication was assessed by histology, 13 C-urea breath test, or stool antigen test. Compliance and adverse events were evaluated by interview. Results: A total of 376 patients were included in the intention-to-treat (ITT) and 352 in the per protocol (PP) analyses. One hundred and ninety-three subjects received probiotics supplementation. Overall, eradication rates were 90.2% (95% Confidence Interval (CI):86.7-93.0) in ITT and 94.6% (95% CI: 91.7-96.7) in PP analyses. The compliance was good (≥90% of treatment taken) in 94.9% of patients. The proportion of patients with a good compliance was not different with and without probiotics supplementation (94.8% vs 95.1%). Eradication rates were equally high for first-line (91.4%), second-line (87.5%), and third-line treatments (91.7%) in the ITT analysis (P = .48). Adverse events were reported by 32.4% of patients, but only 6.1% of patients discontinued treatment. Conclusions: The three-in-one BQT is highly effective and well tolerated for H. pylori eradication in daily clinical practice. Probiotics supplementation fails to improve compliance. (© 2018 John Wiley & Sons Ltd.) |
| فهرسة مساهمة: | Keywords: Helicobacter pylori; Pylera(R); bismuth quadruple therapy; eradication; probiotics supplementation |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (Proton Pump Inhibitors) 140QMO216E (Metronidazole) F8VB5M810T (Tetracycline) U015TT5I8H (Bismuth) |
| تواريخ الأحداث: | Date Created: 20180621 Date Completed: 20181017 Latest Revision: 20201209 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1111/hel.12502 |
| PMID: | 29924430 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1523-5378 |
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| DOI: | 10.1111/hel.12502 |