دورية أكاديمية

Lifetime exposure to ultraviolet radiation and the risk of multiple sclerosis in the US radiologic technologists cohort study.

التفاصيل البيبلوغرافية
العنوان: Lifetime exposure to ultraviolet radiation and the risk of multiple sclerosis in the US radiologic technologists cohort study.
المؤلفون: Gallagher LG; Department of Epidemiology, School of Public Health, Boston University, Boston, MA, USA., Ilango S; Department of Family Medicine and Public Health, University of California, San Diego, San Diego, CA, USA., Wundes A; Department of Neurology, University of Washington, Seattle, WA, USA., Stobbe GA; Department of Neurology, University of Washington, Seattle, WA, USA., Turk KW; Department of Neurology, University of Washington, Seattle, WA, USA., Franklin GM; Department of Environmental & Occupational Health Sciences, University of Washington, Seattle, WA, USA., Linet MS; Division of Cancer Epidemiology & Genetics, National Cancer Institute and DHHS, NIH, Bethesda, MD, USA., Freedman DM; Division of Cancer Epidemiology & Genetics, National Cancer Institute and DHHS, NIH, Bethesda, MD, USA., Alexander BH; Division of Environmental Health Sciences, School of Public Health, University of Minnesota, Minneapolis, MN, USA., Checkoway H; Department of Neurosciences, Department of Family Medicine and Public Health, University of California, San Diego, San Diego, CA, USA.
المصدر: Multiple sclerosis (Houndmills, Basingstoke, England) [Mult Scler] 2019 Jul; Vol. 25 (8), pp. 1162-1169. Date of Electronic Publication: 2018 Jun 22.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: SAGE Publications Country of Publication: England NLM ID: 9509185 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-0970 (Electronic) Linking ISSN: 13524585 NLM ISO Abbreviation: Mult Scler Subsets: MEDLINE
أسماء مطبوعة: Publication: 2006- : London : SAGE Publications
Original Publication: Houndmills, Basingstoke, Hampshire, UK : Stockton Press, c1995-
مواضيع طبية MeSH: Sunlight* , Ultraviolet Rays*, Multiple Sclerosis/*epidemiology, Adult ; Cohort Studies ; Female ; Geographic Mapping ; Humans ; Male ; Medical Laboratory Personnel ; Middle Aged ; Multiple Sclerosis/prevention & control ; Risk ; Technology, Radiologic
مستخلص: Background: Low exposure to ultraviolet radiation (UVR) from sunlight may be a risk factor for developing multiple sclerosis (MS). Possible pathways may be related to effects on immune system function or vitamin D insufficiency, as UVR plays a role in the production of the active form of vitamin D in the body.
Objective: This study examined whether lower levels of residential UVR exposure from sunlight were associated with increased MS risk in a cohort of radiologic technologists.
Methods: Participants in the third and fourth surveys of the US Radiologic Technologists (USRT) Cohort Study eligible ( N  = 39,801) for analysis provided complete residential histories and reported MS diagnoses. MS-specialized neurologists conducted medical record reviews and confirmed 148 cases. Residential locations throughout life were matched to satellite data from NASA's Total Ozone Mapping Spectrometer (TOMS) project to estimate UVR dose.
Results: Findings indicate that MS risk increased as average lifetime levels of UVR exposures in winter decreased. The effects were consistent across age groups <40 years. There was little indication that low exposures during summer or at older ages were related to MS risk.
Conclusion: Our findings are consistent with the hypothesis that UVR exposure reduces MS risk and may ultimately suggest prevention strategies.
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معلومات مُعتمدة: Z01 CP010133 United States ImNIH Intramural NIH HHS
فهرسة مساهمة: Keywords: Epidemiology; ultraviolet radiation; vitamin D
تواريخ الأحداث: Date Created: 20180623 Date Completed: 20200319 Latest Revision: 20231010
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC10561656
DOI: 10.1177/1352458518783343
PMID: 29932357
قاعدة البيانات: MEDLINE
الوصف
تدمد:1477-0970
DOI:10.1177/1352458518783343