دورية أكاديمية
Beneficial effects of cilostazol on liver injury induced by common bile duct ligation in rats: Role of SIRT1 signaling pathway.
| العنوان: | Beneficial effects of cilostazol on liver injury induced by common bile duct ligation in rats: Role of SIRT1 signaling pathway. |
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| المؤلفون: | Kabil SL; Department of Pharmacology, Faculty of Medicine, Zagazig University, Zagazig, Egypt. |
| المصدر: | Clinical and experimental pharmacology & physiology [Clin Exp Pharmacol Physiol] 2018 Dec; Vol. 45 (12), pp. 1341-1350. Date of Electronic Publication: 2018 Jul 25. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: Australia NLM ID: 0425076 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1440-1681 (Electronic) Linking ISSN: 03051870 NLM ISO Abbreviation: Clin Exp Pharmacol Physiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford, England : Wiley-Blackwell Original Publication: Oxford, Blackwell Scientific Publications. |
| مواضيع طبية MeSH: | Cilostazol/*pharmacology , Common Bile Duct/*surgery , Liver/*injuries , Liver/*pathology , Signal Transduction/*drug effects , Sirtuin 1/*metabolism, Alanine Transaminase/blood ; Alkaline Phosphatase/blood ; Animals ; Aspartate Aminotransferases/blood ; Bile Acids and Salts/blood ; Biomarkers/metabolism ; Carbazoles/pharmacology ; Cilostazol/antagonists & inhibitors ; Cilostazol/therapeutic use ; Collagen Type IV/blood ; Cytokines/metabolism ; Gene Expression Regulation, Enzymologic/drug effects ; Hydroxyproline/metabolism ; Ligation/adverse effects ; Liver/drug effects ; Male ; Oxidation-Reduction/drug effects ; Rats ; Rats, Wistar ; Sirtuin 1/antagonists & inhibitors ; Transcription Factor RelA/metabolism ; Transforming Growth Factor beta1/blood ; Up-Regulation/drug effects |
| مستخلص: | Liver fibrosis is a health challenge requiring alternative therapeutic approaches. Cilostazol is a selective phosphodiesterase-3 inhibitor and possesses antioxidant, anti-inflammatory and antifibrotic properties. Sirtuin 1 (SIRT1) is a member of the silent information regulator 2 family. Cilostazol upregulates SIRT1 expression. Cilostazol protects against the cholestatic liver insults caused by bile duct obstruction. Involvement of SIRT1 pathway in this protective effect has not been studied yet. So, we hypothesized that SIRT1 signaling may have a role in cilostazol protective effects against bile duct ligation-induced liver damages. Rats were subjected to common bile duct ligation then treated with cilostazol (9 mg/kg or 27 mg/kg) in the presence or absence of specific SIRT1 inhibitor EX527. Cilostazol improved liver function, reduced inflammation, enhanced antioxidant status, ameliorated cholestatic liver injury and upregulated hepatic SIRT1. However, these protective effects were abrogated by EX527, suggesting that SIRT1 signaling may have a role in these effects. In conclusion, cilostazol in a dose-dependent way produced hepatoprotective effects via anti-inflammatory, antioxidant, antifibrotic effects which were mediated, in part, through SIRT1 upregulation. (© 2018 John Wiley & Sons Australia, Ltd.) |
| فهرسة مساهمة: | Keywords: Sirtuin 1; bile duct ligation; cilostazol; oxidative stress |
| المشرفين على المادة: | 0 (6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide) 0 (Bile Acids and Salts) 0 (Biomarkers) 0 (Carbazoles) 0 (Collagen Type IV) 0 (Cytokines) 0 (Transcription Factor RelA) 0 (Transforming Growth Factor beta1) EC 2.6.1.1 (Aspartate Aminotransferases) EC 2.6.1.2 (Alanine Transaminase) EC 3.1.3.1 (Alkaline Phosphatase) EC 3.5.1.- (Sirtuin 1) N7Z035406B (Cilostazol) RMB44WO89X (Hydroxyproline) |
| تواريخ الأحداث: | Date Created: 20180627 Date Completed: 20191209 Latest Revision: 20191217 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1111/1440-1681.13004 |
| PMID: | 29943424 |
| قاعدة البيانات: | MEDLINE |
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