دورية أكاديمية
أعرض في EDS

Concurrent exposure to heavy metals and cognition in school-age children in Congo-Kinshasa: A complex overdue research agenda.

التفاصيل البيبلوغرافية
العنوان: Concurrent exposure to heavy metals and cognition in school-age children in Congo-Kinshasa: A complex overdue research agenda.
المؤلفون: Bora BK; Department of Neurology, School of Medicine, University of Lubumbashi, Lubumbashi, Democratic Republic of Congo., Ramos-Crawford AL; Department of Neurology and School of Public Health, Oregon Health & Science University, Portland OR, USA., Sikorskii A; Department of Statistics and Probability, Michigan State University, East Lansing, MI, USA., Boivin MJ; Departments of Psychiatry and Neurology & Ophthalmology, Michigan State University, East Lansing MI, USA; Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA., Lez DM; Department of Internal Medicine, School of Medicine, University of Lubumbashi, Lubumbashi, Democratic Republic of Congo., Mumba-Ngoyi D; Department of Tropical Medicine, University of Kinshasa, Kinshasa, Democratic Republic of Congo; National Institute of Biomedical Research (INRB), Kinshasa, Democratic Republic of Congo., Mukalay Wa Mukalay A; School of Public Health, University of Lubumbashi, Lubumbashi, Democratic Republic of Congo., Okitundu-Luwa D; Department of Neurology, University of Kinshasa, Kinshasa, Democratic Republic of Congo., Tshala-Katumbay D; Department of Neurology and School of Public Health, Oregon Health & Science University, Portland OR, USA; Department of Neurology, University of Kinshasa, Kinshasa, Democratic Republic of Congo; National Institute of Biomedical Research (INRB), Kinshasa, Democratic Republic of Congo. Electronic address: tshalad@ohsu.edu.
المصدر: Brain research bulletin [Brain Res Bull] 2019 Feb; Vol. 145, pp. 81-86. Date of Electronic Publication: 2018 Jun 23.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605818 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2747 (Electronic) Linking ISSN: 03619230 NLM ISO Abbreviation: Brain Res Bull Subsets: MEDLINE
أسماء مطبوعة: Publication: New York Ny : Elsevier Science
Original Publication: Phoenix, N. Y. ANKHO International Inc.
مواضيع طبية MeSH: Heavy Metal Poisoning/*epidemiology , Metals, Heavy/*adverse effects , Metals, Heavy/*toxicity, Child ; Child, Preschool ; Cognition/drug effects ; Cognition/physiology ; Cross-Sectional Studies ; Democratic Republic of the Congo/epidemiology ; Female ; Heavy Metal Poisoning/physiopathology ; Humans ; Male
مستخلص: The impact of concurrent exposure to neurotoxic metals is a significant threat to brain function, mostly in contexts of multiple exposures as seen in the developing world. Ninety-five children (46 boys and 49 girls, 6 to 11-year old) from Congo-Kinshasa were assessed for cognition using the Kaufman Assessment Battery for Children (2nd edition) and exposure to Cr, Cu, Zn, Co, Mn, As, Cd, Se, Hg, Fe, and Pb by inductively coupled plasma mass spectrometry (ICPMS) in serum and urine collections. Concentrations of elements were all above normal ranges except for Cd, Se and Hg. General linear mixed effects models were used to predict neurocognitive outcomes with variable selection methods including backward elimination, elastic net, or subsets identified based on subject matter expertise. After adjusting for sex, age, and SES, urinary Co > 5 μg/l was associated with poor simultaneous processing (memory) (p = 0.0237). Higher excretion but normal concentration of Cd in serum was associated with better memory (p = 0.03), planning (p = 0.05), and overall performance scores (p < 0.01); thus appeared to be neuroprotective. However, higher excretion of Zn had negative influence on the overall performance scores (p = 0.02). Predictive neurotoxicology is a challenging task in contexts of multiple and concurrent exposures. Urinary Co > 5 μg/l is a risk factor for poor neurodevelopmental outcomes in such contexts. The impact of heavy metals on cognition is dependent on concentrations of and interactions between toxic and essential elements.
(Copyright © 2018 Elsevier Inc. All rights reserved.)
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معلومات مُعتمدة: R01 ES019841 United States ES NIEHS NIH HHS
فهرسة مساهمة: Keywords: Child development; Cobalt; Cognition; Heavy metals; Neurotoxicity
المشرفين على المادة: 0 (Metals, Heavy)
تواريخ الأحداث: Date Created: 20180627 Date Completed: 20200116 Latest Revision: 20200306
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6631038
DOI: 10.1016/j.brainresbull.2018.06.013
PMID: 29944947
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-2747
DOI:10.1016/j.brainresbull.2018.06.013