دورية أكاديمية
أعرض في EDS

Sex differences influence intestinal epithelial stem cell proliferation independent of obesity.

التفاصيل البيبلوغرافية
العنوان: Sex differences influence intestinal epithelial stem cell proliferation independent of obesity.
المؤلفون: Zhou W; Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois., Davis EA; Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, Illinois., Li K; Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois., Nowak RA; Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois., Dailey MJ; Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois.; Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, Illinois.
المصدر: Physiological reports [Physiol Rep] 2018 Jul; Vol. 6 (13), pp. e13746.
نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society Country of Publication: United States NLM ID: 101607800 Publication Model: Print Cited Medium: Internet ISSN: 2051-817X (Electronic) Linking ISSN: 2051817X NLM ISO Abbreviation: Physiol Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Malden MA] : published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society, 2013-
مواضيع طبية MeSH: Cell Proliferation*, Adult Stem Cells/*physiology , Estrogens/*pharmacology , Intestinal Mucosa/*pathology , Obesity/*pathology, Adult Stem Cells/drug effects ; Adult Stem Cells/metabolism ; Animals ; Cells, Cultured ; Diet, High-Fat/adverse effects ; Female ; Humans ; Intestinal Mucosa/drug effects ; Intestinal Mucosa/metabolism ; MCF-7 Cells ; Male ; Mice ; Mice, Inbred C57BL ; Obesity/etiology ; Obesity/metabolism ; Receptors, Estrogen/genetics ; Receptors, Estrogen/metabolism ; Sex Factors
مستخلص: The intestinal epithelium is continuously regenerated by cell renewal of intestinal epithelial stem cells (IESCs) located in the intestinal crypts. Obesity affects this process and results in changes in the size and cellular make-up of the tissue, but it remains unknown if there are sex differences in obesity-induced alterations in IESC proliferation and differentiation. We fed male and female mice a 60% high-fat diet (HFD) or a 10% low-fat diet (LFD) for 3 months and investigated the differences in (1) the expression of markers of different intestinal epithelial cell types in vivo, and (2) lasting effects on IESC growth in vitro. We found that the growth of IESCs in vitro were enhanced in females compared with males. HFD induced similar in vivo changes and in vitro early growth of IESCs in males and females. The IESCs isolated and grown in vitro from females, though, showed an enhanced growth that was independent of obesity. To determine whether this effect was driven by sex steroid hormones, we used primary intestinal crypts isolated from male and female mice and investigated the differences in (1) the expression of steroid hormone receptors, and (2) cell proliferation in response to steroid hormones. We found that estrogen receptor α was expressed in crypts from both sexes, but estrogen had no effect on proliferation in either sex. These results suggest that obesity similarly effects IESCs in males and females, but IESCs in females have greater proliferation ability than males, but this is not driven by a direct effect of sex steroid hormones on IESCs or other crypt cells that provide essential niche support for IESCs.
(© 2018 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.)
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فهرسة مساهمة: Keywords: GI tract; obesity; proliferation; sex difference; stem cell
المشرفين على المادة: 0 (Estrogens)
0 (Receptors, Estrogen)
تواريخ الأحداث: Date Created: 20180629 Date Completed: 20190904 Latest Revision: 20230926
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC6021372
DOI: 10.14814/phy2.13746
PMID: 29952094
قاعدة البيانات: MEDLINE
الوصف
تدمد:2051-817X
DOI:10.14814/phy2.13746