دورية أكاديمية
أعرض في EDS

LCK as a Potential Therapeutic Target for Acute Rejection after Kidney Transplantation: A Bioinformatics Clue.

التفاصيل البيبلوغرافية
العنوان: LCK as a Potential Therapeutic Target for Acute Rejection after Kidney Transplantation: A Bioinformatics Clue.
المؤلفون: Jia L; Department of Nephrology, Xuanwu Hospital of Capital Medical University, Changchun Street 45#, Beijing 100053, China., Jia R; Central Hospital of Cangzhou, Xinhua Middle Street 201#, Cangzhou, Hebei Province 061001, China., Li Y; Department of Nephrology, Xuanwu Hospital of Capital Medical University, Changchun Street 45#, Beijing 100053, China., Li X; Department of Nephrology, Xuanwu Hospital of Capital Medical University, Changchun Street 45#, Beijing 100053, China., Jia Q; Department of Nephrology, Xuanwu Hospital of Capital Medical University, Changchun Street 45#, Beijing 100053, China., Zhang H; Department of Life Sciences, The National Natural Science Foundation of China, Shuangqing Road 83#, Beijing 100085, China.
المصدر: Journal of immunology research [J Immunol Res] 2018 Jun 07; Vol. 2018, pp. 6451298. Date of Electronic Publication: 2018 Jun 07 (Print Publication: 2018).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Publishing Corporation Country of Publication: Egypt NLM ID: 101627166 Publication Model: eCollection Cited Medium: Internet ISSN: 2314-7156 (Electronic) Linking ISSN: 23147156 NLM ISO Abbreviation: J Immunol Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cairo, Egypt : Hindawi Publishing Corporation, [2014]-
مواضيع طبية MeSH: Kidney Transplantation*, Graft Rejection/*metabolism , Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/*metabolism, Cluster Analysis ; Computational Biology ; Data Mining ; Gene Expression Profiling ; Gene Ontology ; Gene Regulatory Networks ; Graft Rejection/enzymology ; Graft Rejection/genetics ; Graft Rejection/therapy ; Humans ; Kidney/enzymology ; Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/antagonists & inhibitors ; Lymphocytes/metabolism ; Oligonucleotide Array Sequence Analysis ; Protein Interaction Mapping ; Protein Interaction Maps ; Signal Transduction
مستخلص: Objectives: We aim to identify the key biomarker of acute rejection (AR) after kidney transplantation via bioinformatics methods.
Methods: The gene expression data GSE75693 of 30 samples with stable kidney transplantation recipients and 15 AR samples were downloaded and analyzed by the limma package to identify differentially expressed genes (DEGs). Then, Gene Ontology (GO) functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were done to explore the biological functions and potential important pathways of DEGs. Finally, protein-protein interactions (PPIs) and literature mining were applied to construct the cocitation network and to select the hub protein.
Results: A total of 437 upregulated genes and 353 downregulated genes were selected according to P < 0.01 and |log 2 (fold change)| > 1.0. DEGs of AR are mainly located on membranes and impact the activation of receptors in immune responses. In the PPI network, Src kinase, lymphocyte kinase (LCK), CD3G, B2M, interferon- γ , CD3D, tumor necrosis factor, VAV1, and CD3E in the T cell receptor signaling pathway were selected as important factors, and LCK was identified as the hub protein.
Conclusion: LCK, via acting on T-cell receptor, might be a potential therapeutic target for AR after kidney transplantation.
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المشرفين على المادة: EC 2.7.10.2 (Lymphocyte Specific Protein Tyrosine Kinase p56(lck))
تواريخ الأحداث: Date Created: 20180707 Date Completed: 20181018 Latest Revision: 20220318
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC6011083
DOI: 10.1155/2018/6451298
PMID: 29977931
قاعدة البيانات: MEDLINE
الوصف
تدمد:2314-7156
DOI:10.1155/2018/6451298