دورية أكاديمية
Biological Approach for Managing Severe Gunshot Wounds: A Case Report.
| العنوان: | Biological Approach for Managing Severe Gunshot Wounds: A Case Report. |
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| المؤلفون: | Muñoz V; Victoria Muñoz, BS, Quirónsalud Hospital Bizkaia, Erandio, Spain. Carmen Martinez, BS, Quirónsalud Hospital Bizkaia, Erandio, Spain. Begoña Echevarria, BS, Quirónsalud Hospital Bizkaia, Erandio, Spain. Mª Isabel Fernández, BS, Quirónsalud Hospital Bizkaia, Erandio, Spain. Ander Pino, MSc, BTI Biotechnology Institute, Vitoria, Spain. Eduardo Anitua, PhD, MD, DDS, BTI Biotechnology Institute, Vitoria, Spain and Eduardo Anitua Foundation, Vitoria, Spain., Martinez C, Echevarria B, Fernández MI, Pino A, Anitua E |
| المصدر: | Journal of wound, ostomy, and continence nursing : official publication of The Wound, Ostomy and Continence Nurses Society [J Wound Ostomy Continence Nurs] 2018 Jul/Aug; Vol. 45 (4), pp. 359-363. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Mosby-Year Book Country of Publication: United States NLM ID: 9435679 Publication Model: Print Cited Medium: Internet ISSN: 1528-3976 (Electronic) Linking ISSN: 10715754 NLM ISO Abbreviation: J Wound Ostomy Continence Nurs |
| أسماء مطبوعة: | Original Publication: St. Louis, MO : Mosby-Year Book, c1994- |
| مواضيع طبية MeSH: | Wound Healing*, Foot/*physiopathology , Wounds, Gunshot/*nursing, Adult ; Disease Management ; Humans ; Male ; Negative-Pressure Wound Therapy/methods ; Negative-Pressure Wound Therapy/standards ; Platelet-Rich Plasma ; Spain |
| مستخلص: | Background: Autologous formulations rich in bioactive proteins promote cutaneous tissue regeneration. This case report describes our experiences with a platelet-based autologous formulation in the management of a hard-to-heal and severe gunshot wound. Case: A healthy, 34-year-old man suffered an accidental gunshot wound of his right foot. After cleansing with saline and application of vacuum-assisted closure therapy for a period of 5 weeks, the resulting full-thickness wound had a surface area of 20 cm and did not show progress toward closure despite ongoing treatment. Plasma-rich growth factor (PRGF) therapy was used in order to promote tissue regeneration. The patient's own blood was drawn, centrifuged, and platelet-rich plasma was obtained. Intradermal injections of freshly activated platelet-rich plasma were administered into the wound edges, and a fibrin membrane was applied on the wound bed. Afterward, a novel topical ointment based on the patient's own growth factors was used as a daily therapy over the affected tissue. Results: This full-thickness wound healed after 16 weeks of autologous growth factor therapy. The patient was able to walk without pain. Conclusion: Plasma-rich growth factor therapy successfully healed this full-thickness wound that did not respond to a period of 5 weeks with negative pressure wound therapy using a vacuum-assisted device. Healing occurred after 16 weeks of treatment, and he was able to resume walking without pain or functional deficits. |
| تواريخ الأحداث: | Date Created: 20180712 Date Completed: 20190108 Latest Revision: 20190108 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1097/WON.0000000000000451 |
| PMID: | 29994865 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1528-3976 |
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| DOI: | 10.1097/WON.0000000000000451 |