دورية أكاديمية
Complications of Diabetes: An Insight into Genetic Polymorphism and Role of Insulin.
| العنوان: | Complications of Diabetes: An Insight into Genetic Polymorphism and Role of Insulin. |
|---|---|
| المؤلفون: | Aleem S; Department of Biochemistry, Govt. College Women University, Faisalabad, Pakistan., Iqbal R; Department of Biochemistry, Govt. College Women University, Faisalabad, Pakistan., Shar T; Department of Biochemistry, Govt. College Women University, Faisalabad, Pakistan., Noreen S; Department of Biochemistry, Govt. College Women University, Faisalabad, Pakistan., Rafiq N; Department of Biochemistry, Govt. College Women University, Faisalabad, Pakistan., Javed I; Department of Biochemistry, Govt. College Women University, Faisalabad, Pakistan., Kosar S; Department of Biochemistry, Govt. College Women University, Faisalabad, Pakistan., Majeed HN; Department of Biochemistry, Govt. College Women University, Faisalabad, Pakistan., Sattar NA; Department of Biochemistry, Govt. College Women University, Faisalabad, Pakistan., Abid MK; Department of Law, Govt. College University, Faisalabad, Pakistan. |
| المصدر: | Recent patents on inflammation & allergy drug discovery [Recent Pat Inflamm Allergy Drug Discov] 2018; Vol. 12 (1), pp. 78-86. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 101309297 Publication Model: Print Cited Medium: Internet ISSN: 1872-213X (Print) Linking ISSN: 1872213X NLM ISO Abbreviation: Recent Pat Inflamm Allergy Drug Discov Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Saif Zone, Sharjah, U.A.E. : Bentham Science Publishers, 2007-2020. |
| مواضيع طبية MeSH: | Polymorphism, Genetic*, Diabetes Complications/*genetics , Glucokinase/*genetics , Insulin/*physiology, Diabetes Complications/etiology ; Diabetes Mellitus, Type 1/etiology ; Diabetes Mellitus, Type 1/genetics ; Diabetes Mellitus, Type 2/etiology ; Diabetes Mellitus, Type 2/genetics ; Humans ; Insulin Secretion |
| مستخلص: | Background: Diabetes Mellitus (DM) is an advanced and chronic endocrine disorder characterized by an insufficiency of insulin secretion from pancreatic β-cells and liver, adipose tissues, and skeletal muscles. Objective: The main objective of this study is to understand the mechanism and genes which are responsible for the prevalence of diabetes. The study also covers various types of diabetic complications with special reference to insulin role and defects. Methods: The scientific literature and patents were reviewed and analyzed based on their suitability and relevance to the theme of the study. The scientific literature was covered from the authentic databases such as Elsevier, Springer, and Bentham Science. The patents were reviewed from http://www.freepatentsonline.com. Results: Glucokinase (ATP: D-glucose-6-phosphotransferase; GCK), initiates glycolysis and acts as a glucose sensor and metabolic signal producer in liver and pancreas. PCR-sequencing showed qualitative differences in diabetic patients in comparison to healthy subjects. Glucokinase is the most important component in glucose detection of pancreatic islet beta cells in diabetes because glucokinase mutations can be one of the most common single gene disorders described. It is known that a genetic variation of a human glucokinase gene, including a point mutation, causes MODY, the concentration of plasma glucose increased and it is supposed to be the cause of diabetes of the present study subjects. Owing to hyperglycemia and individual components of the insulin resistance (metabolic) syndrome, people with Type II DM are prone to the high threat for microvascular complications (including nephropathy, retinopathy, and neuropathy) and macrovascular complications (such as Ischemic Heart Disease). There were also significant differences (P < 0.0001) in glycation levels (0.90, 0.4838mole/mole), random blood sugar (348.8, 105.8mg/dL), cholesterol levels (235.3, 161.8mg/dL), low density lipoprotein in diabetic subjects (155.3, 28.46mg/dL) and in healthy donors. GCK gene mutations were found in 70% of the patients while 30% are non-mutated. Conclusion: In conclusion, lipids, glucose, and protein play an essential role in the initiation of AGE's or diabetic complications (Micro and Macrovascular Complications). The importance of the clinical results should also be recognized in the genetic analysis of heterogeneous disorders as NIDDM/ Type II DM. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.) |
| فهرسة مساهمة: | Keywords: Diabetes mellitus; MODY; NIDDM; genetics; glucokinase; insulin; polymorphism. |
| المشرفين على المادة: | 0 (Insulin) EC 2.7.1.2 (Glucokinase) |
| تواريخ الأحداث: | Date Created: 20180719 Date Completed: 20181214 Latest Revision: 20181214 |
| رمز التحديث: | 20231215 |
| DOI: | 10.2174/1872213X12666180717165331 |
| PMID: | 30019654 |
| قاعدة البيانات: | MEDLINE |
كن أول من يترك تعليقا!