دورية أكاديمية
The protective effects of sesamol in a neonatal rat model of necrotizing enterocolitis.
| العنوان: | The protective effects of sesamol in a neonatal rat model of necrotizing enterocolitis. |
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| المؤلفون: | Cigsar EB; Department of Pediatric Surgery, Turkiye Cumhuriyeti Saglik Bakanligi Izmir Tepecik Egitim ve Arastirma Hastanesi, Izmir, Turkey., Karadag CA; Department of Pediatric Surgery, Sisli Hamidiye Etfal Egitim ve Arastirma Hastanesi, Istanbul, Turkey., Tanik C; Department of Pathology, Sisli Hamidiye Etfal Egitim ve Arastirma Hastanesi, Istanbul, Turkey., Aydin AF; Department of Biochemistry, Istanbul Universitesi Istanbul Tip Fakultesi, Istanbul, Turkey., Dokucu AI; Department of Pediatric Surgery, Sisli Hamidiye Etfal Egitim ve Arastirma Hastanesi, Istanbul, Turkey. |
| المصدر: | The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians [J Matern Fetal Neonatal Med] 2020 Mar; Vol. 33 (6), pp. 889-894. Date of Electronic Publication: 2018 Sep 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 101136916 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4954 (Electronic) Linking ISSN: 14764954 NLM ISO Abbreviation: J Matern Fetal Neonatal Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: Boca Raton : Parthenon Pub. Group, c2002- |
| مواضيع طبية MeSH: | Anti-Inflammatory Agents/*therapeutic use , Antioxidants/*therapeutic use , Benzodioxoles/*therapeutic use , Enterocolitis, Necrotizing/*drug therapy , Phenols/*therapeutic use , Protective Agents/*therapeutic use, Administration, Oral ; Animals ; Animals, Newborn ; Biomarkers/metabolism ; Enterocolitis, Necrotizing/metabolism ; Enterocolitis, Necrotizing/pathology ; Injections, Intraperitoneal ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/pathology ; Random Allocation ; Rats ; Rats, Wistar ; Severity of Illness Index ; Treatment Outcome |
| مستخلص: | Background and aim: Necrotizing enterocolitis (NEC) is a severe gastrointestinal inflammatory disease associated with high rates of morbidity and mortality. Its pathophysiology includes hypoxic-ischemic injury that may be related to oxygen-derived free radical formation. Sesamol is considered to be an antioxidant and free radical scavenger with anti-inflammatory effects. The aim of this study is to investigate the effects of sesamol in a neonatal rat model of NEC. Materials and methods: The study included 1-day-old Wistar albino rat pups ( n = 34) that were randomly divided into four groups: Group 1 (NEC), group 2 (NEC + intraperitoneal sesamol), group 3 (NEC + oral sesamol), and a control group. NEC was induced by exposure to hypoxia/reoxygenation, following cold stress and hyperosmolar enteral formula feeding. Sesamol 100 mg kg -1 dose -1 was administered intraperitoneally to group 2 and orally to group 3 for 3 days. On day 4 all rats were sacrificed. Histological injuries, the Bcl-2, caspase-3, malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione-peroxidase (GSH-Px) activities were measured in intestinal samples. Results: The grade of intestinal damage, and Bcl-2 and caspase-3 levels in group 1 were significantly higher than in groups 2 and 3 and the control group, and intestinal damage was significantly more severe in group 1 than in groups 2 and 3. The MDA activity was significantly lower in groups 2 and 3 than in group 1 (112, 89, and 144 nmol mL -1 , respectively). Groups 2 and 3 had significantly higher SOD and GSH-Px activities than group 1 (SOD: 1.75, 1.74, and 0.89 U mg -1 ; GSH-Px: 114, 121, and 110 nmol of NADPH min -1 mg -1 , respectively). Conclusions: The present findings highlight that sesamol has beneficial effects on intestinal injury in a rat model of NEC through its antioxidant and anti-inflammatory properties. |
| فهرسة مساهمة: | Keywords: Enterocolitis; NEC; newborn; sesamol |
| المشرفين على المادة: | 0 (Anti-Inflammatory Agents) 0 (Antioxidants) 0 (Benzodioxoles) 0 (Biomarkers) 0 (Phenols) 0 (Protective Agents) 94IEA0NV89 (sesamol) |
| تواريخ الأحداث: | Date Created: 20180731 Date Completed: 20201119 Latest Revision: 20201119 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1080/14767058.2018.1506759 |
| PMID: | 30058400 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1476-4954 |
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| DOI: | 10.1080/14767058.2018.1506759 |