دورية أكاديمية
Gallium-68-prostate-specific membrane antigen ( 68 Ga-PSMA) positron emission tomography (PET)/computed tomography (CT) predicts complete biochemical response from radical prostatectomy and lymph node dissection in intermediate- and high-risk prostate cancer.
| العنوان: | Gallium-68-prostate-specific membrane antigen ( 68 Ga-PSMA) positron emission tomography (PET)/computed tomography (CT) predicts complete biochemical response from radical prostatectomy and lymph node dissection in intermediate- and high-risk prostate cancer. |
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| المؤلفون: | van Leeuwen PJ; Department of Urology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Donswijk M; Department of Nuclear Medicine, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Nandurkar R; Faculty of Medicine, University of New South Wales Sydney, Sydney, New South Wales, Australia., Stricker P; The Australian Prostate Cancer Research Centre-NSW, The Garvan Institute of Medical Research, Sydney, New South Wales, Australia.; St Vincent's Clinic, Sydney, New South Wales, Australia., Ho B; Department of Theranostics and Nuclear Medicine, St Vincent's Hospital Sydney, Sydney, New South Wales, Australia., Heijmink S; Department of Radiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Wit EMK; Department of Urology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Tillier C; Department of Urology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., van Muilenkom E; Department of Urology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Nguyen Q; The Australian Prostate Cancer Research Centre-NSW, The Garvan Institute of Medical Research, Sydney, New South Wales, Australia., van der Poel HG; Department of Urology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Emmett L; Faculty of Medicine, University of New South Wales Sydney, Sydney, New South Wales, Australia.; The Australian Prostate Cancer Research Centre-NSW, The Garvan Institute of Medical Research, Sydney, New South Wales, Australia.; Department of Theranostics and Nuclear Medicine, St Vincent's Hospital Sydney, Sydney, New South Wales, Australia. |
| المصدر: | BJU international [BJU Int] 2019 Jul; Vol. 124 (1), pp. 62-68. Date of Electronic Publication: 2019 Apr 07. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Blackwell Science Country of Publication: England NLM ID: 100886721 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-410X (Electronic) Linking ISSN: 14644096 NLM ISO Abbreviation: BJU Int Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford, UK : Blackwell Science, c1999- |
| مواضيع طبية MeSH: | Lymph Node Excision* , Positron Emission Tomography Computed Tomography* , Prostatectomy*, Prostate-Specific Antigen/*blood , Prostatic Neoplasms/*blood , Prostatic Neoplasms/*diagnostic imaging, Aged ; Gallium Radioisotopes ; Humans ; Lymphatic Metastasis ; Male ; Middle Aged ; Neoplasm Staging ; Predictive Value of Tests ; Prostatic Neoplasms/surgery |
| مستخلص: | Objective: To determine the value of gallium-68-prostate-specific membrane antigen ( 68 Ga-PSMA)-11 positron emission tomography (PET) /computed tomography (CT) in men with newly diagnosed prostate cancer. Patients and Methods: We analysed results of 140 men with intermediate- and high-risk prostate cancer. All men underwent 68 Ga-PSMA-11 PET/CT and multiparametric magnetic resonance imaging (mpMRI) before radical prostatectomy (RP) with extended pelvic lymph node (LN) dissection. For each patient, the clinical and pathological features were recorded. Prostate-specific antigen (PSA) was documented at staging scan, and after RP, at a median (interquartile range) of 110 (49-132) days. A PSA level of ≥0.03 ng/mL was classified as biochemical persistence (BCP). Logistic regression was performed for association of clinical variables and BCP. Results: In these 140 patients with intermediate- and high-risk prostate cancer, 27.1% had PSMA PET/CT-positive findings in the pelvic LNs. Sensitivity and specificity for detection of LN metastases were 53% and 88% (PSMA PET/CT) and 14% and 99% (mpMRI), respectively. The overall BCP rate was 25.7%. The BCP rate was 16.7% in men who were PSMA PET/CT LN-negative compared to 50% in men who were PSMA PET/CT LN-positive (P < 0.05). The presence of PSMA-positive pelvic LNs was more predictive of BCP after RP than cT-stage, PSA level, and the Gleason score, adjusted for surgical margins status. Conclusions: 68 Ga-PSMA-11 PET/CT is highly predictive of BCP after RP, and should play an important role informing men with intermediate- or high-risk prostate cancer. (© 2018 The Authors BJU International © 2018 BJU International Published by John Wiley & Sons Ltd.) |
| التعليقات: | Comment in: BJU Int. 2019 Jul;124(1):2-3. (PMID: 31207000) |
| فهرسة مساهمة: | Keywords: #PCSM; #ProstateCancer; accuracy; biochemical recurrence; positron emission tomography; prostate-specific membrane antigen; radical prostatectomy |
| المشرفين على المادة: | 0 (Gallium Radioisotopes) 98B30EPP5S (Gallium-68) EC 3.4.21.77 (Prostate-Specific Antigen) |
| تواريخ الأحداث: | Date Created: 20180804 Date Completed: 20200217 Latest Revision: 20200217 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1111/bju.14506 |
| PMID: | 30074667 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1464-410X |
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| DOI: | 10.1111/bju.14506 |