دورية أكاديمية
Polymorphisms of Catechol-O-Methyl Transferase (COMT) Gene in Vulnerability to Levodopa-Induced Dyskinesia.
| العنوان: | Polymorphisms of Catechol-O-Methyl Transferase (COMT) Gene in Vulnerability to Levodopa-Induced Dyskinesia. |
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| المؤلفون: | Ivanova SA, Alifirova VM, Pozhidaev IV, Freidin MB, Zhukova IA, Osmanova DZ, Zhukova NG, Mironova YA, Tiguntsev VV, Fedorenko OY, Bokhan NA, Wilffert B, Loonen AJM |
| المصدر: | Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques [J Pharm Pharm Sci] 2018; Vol. 21 (1), pp. 340-346. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Media S. A Country of Publication: Switzerland NLM ID: 9807281 Publication Model: Print Cited Medium: Internet ISSN: 1482-1826 (Electronic) Linking ISSN: 14821826 NLM ISO Abbreviation: J Pharm Pharm Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2023- : Lausanne, Switzerland : Frontiers Media S. A. Original Publication: [Edmonton, Alta.] : The Society, c1997- |
| مواضيع طبية MeSH: | Antiparkinson Agents/*adverse effects , Catechol O-Methyltransferase/*genetics , Dyskinesia, Drug-Induced/*genetics , Levodopa/*adverse effects , Parkinson Disease/*drug therapy , Polymorphism, Single Nucleotide/*genetics, Adult ; Aged ; Aged, 80 and over ; Antiparkinson Agents/therapeutic use ; Dyskinesia, Drug-Induced/enzymology ; Dyskinesia, Drug-Induced/prevention & control ; Female ; Humans ; Levodopa/therapeutic use ; Male ; Middle Aged ; Parkinson Disease/enzymology ; Parkinson Disease/genetics ; Regression Analysis |
| مستخلص: | Purpose: Parkinson's disease (PD), a common neurodegenerative disorder, is usually treated with Levodopa (L-DOPA). The use of this drug, however, is severely limited by the development of side effects of the motor system: Levodopa-induced dyskinesia (LID). The aim of this study is to investigate the association between seven COMT gene single-nucleotide polymorphisms (SNPs) and the development of LID in patients with PD. Methods: 232 Caucasian patients with PD were investigated. 212 patients with PD received Levodopa therapy. Dyskinesia was assessed with the use of the Abnormal Involuntary Movement Scale (AIMS). Genotyping was carried out on seven SNPs of the COMT gene (rs4680, rs6269, rs4633, rs4818, rs769224, rs165774, rs174696) using a real-time PCR method, and blind to the clinical status of the subjects. Results: We found association between four SNPs, rs165774, rs4818, rs4633, rs4680, and LID. When the duration of disease was added as a covariate in regression analysis, however, the results did not reach statistical significance. Only the additive model for rs165774 was found to be close to be statistical significance (OR = 1.627 [0.976-2.741], permutation p = 0.057). Conclusions: The results failed to clearly support a contribution of the studied polymorphisms; this may be related to a dominant relationship with the disease duration confounding the effect on the prevalence of LID. |
| المشرفين على المادة: | 0 (Antiparkinson Agents) 46627O600J (Levodopa) EC 2.1.1.6 (Catechol O-Methyltransferase) |
| تواريخ الأحداث: | Date Created: 20180805 Date Completed: 20190923 Latest Revision: 20190923 |
| رمز التحديث: | 20240829 |
| DOI: | 10.18433/jpps29903 |
| PMID: | 30075828 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1482-1826 |
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| DOI: | 10.18433/jpps29903 |