دورية أكاديمية
أعرض في EDS

Clock gene expression and locomotor activity predict death in the last days of life in Drosophila melanogaster.

التفاصيل البيبلوغرافية
العنوان: Clock gene expression and locomotor activity predict death in the last days of life in Drosophila melanogaster.
المؤلفون: Zhao J; Department of Anaesthesiology, School of Medicine, the University of Auckland, Park Road, Grafton, Auckland, 1023, New Zealand., Warman GR; Department of Anaesthesiology, School of Medicine, the University of Auckland, Park Road, Grafton, Auckland, 1023, New Zealand., Cheeseman JF; Department of Anaesthesiology, School of Medicine, the University of Auckland, Park Road, Grafton, Auckland, 1023, New Zealand. j.cheeseman@auckland.ac.nz.
المصدر: Scientific reports [Sci Rep] 2018 Aug 09; Vol. 8 (1), pp. 11923. Date of Electronic Publication: 2018 Aug 09.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Gene Expression Regulation, Developmental*, CLOCK Proteins/*genetics , Drosophila Proteins/*genetics , Drosophila melanogaster/*genetics , Locomotion/*genetics , Period Circadian Proteins/*genetics, Aging/genetics ; Animals ; Animals, Genetically Modified ; Circadian Clocks/genetics ; Circadian Rhythm/genetics ; Drosophila melanogaster/growth & development ; Longevity/genetics ; Photoperiod ; Survival Analysis
مستخلص: The importance of the circadian clock for the regulation of behaviour and physiology, and the molecular control of these rhythms by a set of clock genes are well defined. The circadian clock deteriorates with advancing age but the mechanism underlying is unclear. Here we recorded the expression of two key clock genes in young, middle-aged and old Drosophila using transgenic luciferase lines reporting period and timeless in vivo. We report a novel marker of imminent death in the expression of TIMELESS. In the days immediately preceding death TIMELESS expression increased to at least 150% of previous acrophase values (88.0% of n = 217) and lost circadian rhythmicity, which predicted death equally well in flies of different ages and under light and temperature cycles. We suggest this transient aberrant clock-gene expression is central to the mechanism of the disturbance in circadian behaviour before death (82.7% of n = 342). We also find that PERIOD expression in central-clock neurons remained robust with age, however PERIOD and TIMELESS in peripheral clocks showed a reduction in both expression level and rhythmicity. In conclusion, as flies age the molecular clock gradually declines at the peripheral level but continues to function at the central until days before death.
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المشرفين على المادة: 0 (Clk protein, Drosophila)
0 (Drosophila Proteins)
0 (Period Circadian Proteins)
0 (tim protein, Drosophila)
EC 2.3.1.48 (CLOCK Proteins)
تواريخ الأحداث: Date Created: 20180811 Date Completed: 20191028 Latest Revision: 20191028
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC6085321
DOI: 10.1038/s41598-018-30323-x
PMID: 30093652
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-018-30323-x