دورية أكاديمية
Heterogenous expression of ERG oncoprotein in Malaysian men with adenocarcinoma of the prostate.
| العنوان: | Heterogenous expression of ERG oncoprotein in Malaysian men with adenocarcinoma of the prostate. |
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| المؤلفون: | Tan JSJ; University of Malaya, Faculty of Medicine, Departments of Pathology, Kuala Lumpur, Malaysia. carhodes60@gmail.com., Ong KC, Ong DBL, Razack A, Lim J, Yunus R, Sundram M, Rhodes A |
| المصدر: | The Malaysian journal of pathology [Malays J Pathol] 2018 Aug; Vol. 40 (2), pp. 103-110. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academy of Medicine of Malyasia, College of Pathologists Country of Publication: Malaysia NLM ID: 8101177 Publication Model: Print Cited Medium: Internet ISSN: 0126-8635 (Print) Linking ISSN: 01268635 NLM ISO Abbreviation: Malays J Pathol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: June 2000- : Kuala Lumpur : Academy of Medicine of Malyasia, College of Pathologists Original Publication: Kuala Lumpur : Malaysian Society of Pathologists. |
| مواضيع طبية MeSH: | Adenocarcinoma/*pathology , Biomarkers, Tumor/*analysis , Prostatic Neoplasms/*pathology, Aged ; Humans ; Malaysia ; Male ; Middle Aged ; Transcriptional Regulator ERG/analysis ; Transcriptional Regulator ERG/biosynthesis |
| مستخلص: | Introduction: Prostate cancer is a heterogenous disease and the mechanisms that drive it to behave differently are not well understood. Tumour expression of the ERG oncogene occurs in the majority of patients with prostate cancer in Western studies. This is considered to be oncogenic as ERG acts as a transcription factor to regulate genes involved in tumour proliferation and invasion. In this study we investigated expression of ERG in Malaysian men with prostate cancer. Methods: Tissues were collected from 80 patients with clinically detected prostate cancer and treated with radical prostatectomy. Cases were tested for ERG by immunohistochemistry using the mouse monoclonal antibody EP111. All blocks on 48 cases were tested in order to determine the extent of heterogeneity of ERG expression within individual cases. ERG expression was analysed in relation to patient age, ethnicity and tumour stage and grade. Results: Forty-six percent of cases were ERG positive. There was no significant association between ERG and tumour grade or stage. Sixty-nine percent of Indian patients had ERG positive tumours; this was significantly higher (p=0.031) than for Chinese (40%) and Malay (44%) patients. Heterogeneity of ERG expression, in which both positive and negative clones were present, was seen in 35% of evaluated cases. Evaluation by tumour foci showed younger patients had more ERG positive tumour foci than older patients (p=0.01). Indian patients were more likely to have the majority of tumour foci with ERG staining positively, compared to either Chinese or Malay patients (P <0.01). Conclusion: In this study, tumour expression of ERG was more likely to occur in patients of Indian ethnicity. |
| المشرفين على المادة: | 0 (Biomarkers, Tumor) 0 (ERG protein, human) 0 (Transcriptional Regulator ERG) |
| تواريخ الأحداث: | Date Created: 20180903 Date Completed: 20181211 Latest Revision: 20181211 |
| رمز التحديث: | 20231215 |
| PMID: | 30173226 |
| قاعدة البيانات: | MEDLINE |
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