دورية أكاديمية
أعرض في EDS

Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse model.

التفاصيل البيبلوغرافية
العنوان: Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse model.
المؤلفون: Choi SH; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA., Bylykbashi E; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA., Chatila ZK; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA., Lee SW; Laboratoy of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA., Pulli B; Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA., Clemenson GD; Laboratoy of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA., Kim E; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA., Rompala A; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA., Oram MK; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA., Asselin C; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA., Aronson J; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA., Zhang C; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA., Miller SJ; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA., Lesinski A; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA., Chen JW; Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA., Kim DY; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA., van Praag H; Department of Biomedical Science, Charles E. Schmidt College of Medicine, and Brain Institute, Florida Atlantic University, Jupiter, FL 33458, USA., Spiegelman BM; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Gage FH; Laboratoy of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA., Tanzi RE; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA. tanzi@helix.mgh.harvard.edu.
المصدر: Science (New York, N.Y.) [Science] 2018 Sep 07; Vol. 361 (6406).
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
أسماء مطبوعة: Publication: : Washington, DC : American Association for the Advancement of Science
Original Publication: New York, N.Y. : [s.n.] 1880-
مواضيع طبية MeSH: Cognition* , Exercise* , Neurogenesis*/drug effects, Alzheimer Disease/*psychology , Alzheimer Disease/*therapy , Brain-Derived Neurotrophic Factor/*metabolism , Hippocampus/*cytology, Alzheimer Disease/pathology ; Amyloid beta-Peptides ; Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/metabolism ; Animals ; Carbazoles/administration & dosage ; Carbazoles/pharmacology ; Cell Death ; Disease Models, Animal ; Female ; Fibronectins ; Humans ; Interleukin-6/metabolism ; Male ; Mice ; Mice, Transgenic ; Physical Conditioning, Animal ; Wnt3 Protein/genetics
مستخلص: Adult hippocampal neurogenesis (AHN) is impaired before the onset of Alzheimer's disease (AD) pathology. We found that exercise provided cognitive benefit to 5×FAD mice, a mouse model of AD, by inducing AHN and elevating levels of brain-derived neurotrophic factor (BDNF). Neither stimulation of AHN alone, nor exercise, in the absence of increased AHN, ameliorated cognition. We successfully mimicked the beneficial effects of exercise on AD mice by genetically and pharmacologically inducing AHN in combination with elevating BDNF levels. Suppressing AHN later led to worsened cognitive performance and loss of preexisting dentate neurons. Thus, pharmacological mimetics of exercise, enhancing AHN and elevating BDNF levels, may improve cognition in AD. Furthermore, applied at early stages of AD, these mimetics may protect against subsequent neuronal cell death.
(Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.)
التعليقات: Comment in: Science. 2018 Sep 7;361(6406):975-976. doi: 10.1126/science.aau8060. (PMID: 30190391)
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معلومات مُعتمدة: R01 AG014713 United States AG NIA NIH HHS; R01 AG055784 United States AG NIA NIH HHS; R01 MH060009 United States MH NIMH NIH HHS; RF1 AG048080 United States AG NIA NIH HHS
المشرفين على المادة: 0 (APP protein, human)
0 (Amyloid beta-Peptides)
0 (Amyloid beta-Protein Precursor)
0 (Brain-Derived Neurotrophic Factor)
0 (Carbazoles)
0 (FNDC5 protein, human)
0 (Fibronectins)
0 (Interleukin-6)
0 (P7C3 compound)
0 (Wnt3 Protein)
0 (Wnt3 protein, mouse)
0 (interleukin-6, mouse)
تواريخ الأحداث: Date Created: 20180908 Date Completed: 20181114 Latest Revision: 20240610
رمز التحديث: 20240610
مُعرف محوري في PubMed: PMC6149542
DOI: 10.1126/science.aan8821
PMID: 30190379
قاعدة البيانات: MEDLINE
الوصف
تدمد:1095-9203
DOI:10.1126/science.aan8821