دورية أكاديمية
Vitamin D supplementation may improve back pain disability in vitamin D deficient and overweight or obese adults.
| العنوان: | Vitamin D supplementation may improve back pain disability in vitamin D deficient and overweight or obese adults. |
|---|---|
| المؤلفون: | Brady SRE; Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, 3004, Australia., Naderpoor N; Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, 43-51, Kanooka Grove, Clayton, VIC, 3168 Australia., de Courten MPJ; Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, 3004, Australia; Centre for Chronic Disease Prevention, Victoria University, Melbourne, VIC, 3021, Australia., Scragg R; School of Population Health, University of Auckland, Auckland, New Zealand., Cicuttini F; Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, 3004, Australia., Mousa A; Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, 43-51, Kanooka Grove, Clayton, VIC, 3168 Australia., de Courten B; Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, 43-51, Kanooka Grove, Clayton, VIC, 3168 Australia. Electronic address: barbora.decourten@monash.edu. |
| المصدر: | The Journal of steroid biochemistry and molecular biology [J Steroid Biochem Mol Biol] 2019 Jan; Vol. 185, pp. 212-217. Date of Electronic Publication: 2018 Sep 07. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pergamon Country of Publication: England NLM ID: 9015483 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1220 (Electronic) Linking ISSN: 09600760 NLM ISO Abbreviation: J Steroid Biochem Mol Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford ; New York : Pergamon, c1990- |
| مواضيع طبية MeSH: | Back Pain/*diet therapy , Calcium-Regulating Hormones and Agents/*therapeutic use , Cholecalciferol/*therapeutic use , Obesity/*pathology , Vitamin D/*analogs & derivatives , Vitamin D Deficiency/*diet therapy, Adult ; Body Mass Index ; Double-Blind Method ; Female ; Humans ; Male ; Surveys and Questionnaires ; Vitamin D/blood |
| مستخلص: | Back pain is currently the greatest cause of disability worldwide, and there are very limited therapeutic options available. Vitamin D deficiency and obesity are both risk factors for back pain. The few randomised controlled trials examining the effects of vitamin D supplementation on back pain have methodological limitations and largely include non-vitamin D deficient participants. Thus, the aim of this study was to determine whether vitamin D supplementation improves back pain symptoms in vitamin D deficient and overweight or obese, otherwise healthy adults. Sixty-five overweight or obese adults (BMI ≥ 25 kg/m 2 ) with vitamin D deficiency (25-hydroxyvitamin D [25(OH)D] concentrations ≤50 nmol/L) were randomised to a bolus oral dose of 100,000 IU followed by 4000 IU cholecalciferol/day or matching placebo for 16 weeks. We measured 25(OH)D concentrations (chemiluminescent immunoassays) and self-reported back pain (Chronic Pain Grade Questionnaire) before and after the intervention. Lifestyle habits including sun exposure, physical activity, and diet were collected using questionnaires. Fifty-four participants completed the study, of which 49 had complete data for back pain and were included in the present analyses (31 M/18 F; mean ± SD age: 31.8 ± 8.9 years; BMI: 31.1 ± 4.5 kg/m 2 ). After the 16-week intervention, 25(OH)D levels increased significantly with vitamin D supplementation compared with placebo (55.7 ± 20.9 versus 3.9 ± 14.4 nmol/L, respectively, p < 0.001). There were no significant differences between vitamin D and placebo groups in change in back pain intensity or disability scores (all p > 0.05). However, in those with 25(OH)D concentrations <30 nmol/L at baseline (n = 20), there was a significantly greater reduction in back pain disability scores in the vitamin D group compared with placebo, after adjusting for important covariates known to affect vitamin D status and/or back pain (b [95%CI] = -11.6 [-22.4, -0.8], p = 0.04). Our findings suggest that vitamin D supplementation in overweight or obese and markedly vitamin D deficient adults (25(OH)D <30 nmol/L) may improve back pain disability. Although treating severe vitamin D deficiency is recommended for optimising bone health, this study suggests it may also improve back pain. Hence, testing for vitamin D deficiency in those with back pain who are overweight or obese may be warranted. (Copyright © 2018 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Back pain; Overweight and obesity; Randomised controlled trial; Vitamin D |
| المشرفين على المادة: | 0 (Calcium-Regulating Hormones and Agents) 1406-16-2 (Vitamin D) 1C6V77QF41 (Cholecalciferol) A288AR3C9H (25-hydroxyvitamin D) |
| تواريخ الأحداث: | Date Created: 20180912 Date Completed: 20190514 Latest Revision: 20190514 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.jsbmb.2018.09.005 |
| PMID: | 30201225 |
| قاعدة البيانات: | MEDLINE |
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