دورية أكاديمية
أعرض في EDS

Apolipoprotein E Epsilon 4 Genotype, Mild Traumatic Brain Injury, and the Development of Chronic Traumatic Encephalopathy.

التفاصيل البيبلوغرافية
العنوان: Apolipoprotein E Epsilon 4 Genotype, Mild Traumatic Brain Injury, and the Development of Chronic Traumatic Encephalopathy.
المؤلفون: Deng H; Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94122, USA. hansen.deng@ucsf.edu., Ordaz A; Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94122, USA. angel.ordaz@ucsf.edu., Upadhyayula PS; Department of Neurological Surgery, University of California San Diego, San Diego, CA 92093, USA. psupadhy@ucsd.edu., Gillis-Buck EM; Department of Surgery, University of California San Francisco, San Francisco, CA 94122, USA. eva.gillis-buck@ucsf.edu.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. eva.gillis-buck@ucsf.edu., Suen CG; Department of Neurology, University of Utah, Salt Lake City, UT 84112, USA. catherine.suen@hsc.utah.edu., Melhado CG; Department of Surgery, University of California San Francisco, San Francisco, CA 94122, USA. caroline.melhado@ucsf.edu., Mohammed N; Department of Pathology, University of California San Francisco, San Francisco, CA 94122, USA. nebil.mohammed@ucsf.edu., Lam T; Department of Oral and Maxillofacial Surgery, University of California San Francisco, San Francisco, CA 94122, USA. troy.lam@ucsf.edu., Yue JK; Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94122, USA. John.Yue@ucsf.edu.
المصدر: Medical sciences (Basel, Switzerland) [Med Sci (Basel)] 2018 Sep 14; Vol. 6 (3). Date of Electronic Publication: 2018 Sep 14.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101629322 Publication Model: Electronic Cited Medium: Internet ISSN: 2076-3271 (Electronic) Linking ISSN: 20763271 NLM ISO Abbreviation: Med Sci (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2013]-
مستخلص: The annual incidence of mild traumatic brain injury (MTBI) is 3.8 million in the USA with 10⁻15% experiencing persistent morbidity beyond one year. Chronic traumatic encephalopathy (CTE), a neurodegenerative disease characterized by accumulation of hyperphosphorylated tau, can occur with repetitive MTBI. Risk factors for CTE are challenging to identify because injury mechanisms of MTBI are heterogeneous, clinical manifestations and management vary, and CTE is a postmortem diagnosis, making prospective studies difficult. There is growing interest in the genetic influence on head trauma and development of CTE. Apolipoprotein epsilon 4 ( APOE-ε4 ) associates with many neurologic diseases, and consensus on the ε4 allele as a risk factor is lacking. This review investigates the influence of APOE-ε4 on MTBI and CTE. A comprehensive PubMed literature search (1966 to 12 June 2018) identified 24 unique reports on the topic (19 MTBI studies: 8 athletic, 5 military, 6 population-based; 5 CTE studies: 4 athletic and military, 1 leucotomy group). APOE-ε4 genotype is found to associate with outcomes in 4/8 athletic reports, 3/5 military reports, and 5/6 population-based reports following MTBI. Evidence on the association between APOE-ε4 and CTE from case series is equivocal. Refining modalities to aid CTE diagnosis in larger samples is needed in MTBI.
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فهرسة مساهمة: Keywords: apolipoprotein E; chronic traumatic encephalopathy; concussion; genetic risk factors; mild traumatic brain injury; neurodegenerative disorders
تواريخ الأحداث: Date Created: 20180919 Latest Revision: 20240401
رمز التحديث: 20240401
مُعرف محوري في PubMed: PMC6163513
DOI: 10.3390/medsci6030078
PMID: 30223506
قاعدة البيانات: MEDLINE
الوصف
تدمد:2076-3271
DOI:10.3390/medsci6030078