دورية أكاديمية
Simultaneous Model Selection and Model Calibration for the Proliferation of Tumor and Normal Cells During In Vitro Chemotherapy Experiments.
| العنوان: | Simultaneous Model Selection and Model Calibration for the Proliferation of Tumor and Normal Cells During In Vitro Chemotherapy Experiments. |
|---|---|
| المؤلفون: | Costa JMJ; Department of Statistics, Federal University of Amazonas-UFAM, Manaus, Brazil.; Department of Mechanical Engineering, Federal University of Rio de Janeiro-UFRJ, Rio de Janeiro, Brazil., Orlande HRB; Department of Mechanical Engineering, Federal University of Rio de Janeiro-UFRJ, Rio de Janeiro, Brazil., Lione VOF; Laboratory of Pharmaceutical Bioassays, Faculty of Pharmacy, Federal University of Rio de Janeiro-UFRJ, Rio de Janeiro, Brazil., Lima AGF; Laboratory of Pharmaceutical Bioassays, Faculty of Pharmacy, Federal University of Rio de Janeiro-UFRJ, Rio de Janeiro, Brazil., Cardoso TCS; Laboratory of Pharmaceutical Bioassays, Faculty of Pharmacy, Federal University of Rio de Janeiro-UFRJ, Rio de Janeiro, Brazil., Varón LAB; Department of Mechanical Engineering, Federal University of Rio de Janeiro-UFRJ, Rio de Janeiro, Brazil.; Department of Bioengineering, School of Engineering, University of Santiago de Cali, Cali, Colombia. |
| المصدر: | Journal of computational biology : a journal of computational molecular cell biology [J Comput Biol] 2018 Dec; Vol. 25 (12), pp. 1285-1300. Date of Electronic Publication: 2018 Sep 22. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 9433358 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-8666 (Electronic) Linking ISSN: 10665277 NLM ISO Abbreviation: J Comput Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Mary Ann Liebert, Inc., c1994- |
| مواضيع طبية MeSH: | Models, Theoretical*, Antineoplastic Agents/*pharmacology , Cell Proliferation/*drug effects , Doxorubicin/*pharmacology , Prostatic Neoplasms/*pathology, Animals ; Cell Line, Tumor ; Drug Resistance, Neoplasm ; Humans ; Male ; Mice ; RAW 264.7 Cells |
| مستخلص: | In vitro experiments were conducted in this work to analyze the proliferation of tumor (DU-145) and normal (macrophage RAW 264.7) cells under the influence of a chemotherapeutic drug (doxorubicin). Approximate Bayesian Computation (ABC) was used to select among four competing models to represent the number of cells and to estimate the model parameters, based on the experimental data. For one case, the selected model was validated in a replicated experiment, through the solution of a state estimation problem with a particle filter algorithm, thus demonstrating the robustness of the ABC procedure used in this work. |
| فهرسة مساهمة: | Keywords: DU-145 cells; RAW 264.7 cells; approximate Bayesian computation; chemotherapy; state estimation. |
| المشرفين على المادة: | 0 (Antineoplastic Agents) 80168379AG (Doxorubicin) |
| تواريخ الأحداث: | Date Created: 20180926 Date Completed: 20200611 Latest Revision: 20200611 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1089/cmb.2017.0130 |
| PMID: | 30251882 |
| قاعدة البيانات: | MEDLINE |
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